Michele Gabriele
@michelegabriele.bsky.social
from 🇮🇹 | former @AICF_nyc and K99 @MIT |
#newlab in SR-TIGET June 2025
| #Chromatin | #Microscopy | #FirstGen
www.gabrielelab.com
#newlab in SR-TIGET June 2025
| #Chromatin | #Microscopy | #FirstGen
www.gabrielelab.com
Welcome to Sabrina Savoia and Ilaria Locatelli, the first members of the lab! We are officially operative! 🥳 gabrielelab.com/team
September 19, 2025 at 1:49 PM
Welcome to Sabrina Savoia and Ilaria Locatelli, the first members of the lab! We are officially operative! 🥳 gabrielelab.com/team
At SR-Tiget we are seeking outstanding mid-career scientists in Computational biology, AI, and Molecular immunology who wish to translate their results into therapeutic advances with a focus on genetic diseases! Deadline 1st September 2025! www.linkedin.com/posts/sr-tig...
www.linkedin.com
July 18, 2025 at 11:27 AM
At SR-Tiget we are seeking outstanding mid-career scientists in Computational biology, AI, and Molecular immunology who wish to translate their results into therapeutic advances with a focus on genetic diseases! Deadline 1st September 2025! www.linkedin.com/posts/sr-tig...
Are you a mid-career group leader in computational bio/AI/molecular immunology who wants to move the lab to Italy? (preferentially from USA?) The SR-TIGET (Milan, Italy) is recruiting someone like you! Here the call:
back.fondazionetelethon.it/uploads/2025...
back.fondazionetelethon.it/uploads/2025...
back.fondazionetelethon.it
June 23, 2025 at 4:17 PM
Are you a mid-career group leader in computational bio/AI/molecular immunology who wants to move the lab to Italy? (preferentially from USA?) The SR-TIGET (Milan, Italy) is recruiting someone like you! Here the call:
back.fondazionetelethon.it/uploads/2025...
back.fondazionetelethon.it/uploads/2025...
Have you recently finished your PhD and had excellent productivity? Telethon foundation is starting a postdoctoral program with a competetive 3-years fully funded position! Send CV and PI preference (included me, I am not yet in the website) details here: back.fondazionetelethon.it/uploads/2025...
back.fondazionetelethon.it
June 23, 2025 at 4:17 PM
Have you recently finished your PhD and had excellent productivity? Telethon foundation is starting a postdoctoral program with a competetive 3-years fully funded position! Send CV and PI preference (included me, I am not yet in the website) details here: back.fondazionetelethon.it/uploads/2025...
Reposted by Michele Gabriele
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We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
May 14, 2025 at 5:58 PM
3/
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
This new preprint from my labmates provides a new perspective on chromatin dynamics! Strongly suggested to everyone into chromatin given its broad impact!
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Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
May 15, 2025 at 4:35 PM
This new preprint from my labmates provides a new perspective on chromatin dynamics! Strongly suggested to everyone into chromatin given its broad impact!
📢 New Lab Alert! 📢
I am very excited to share that starting this summer, I will open my laboratory at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy! www.linkedin.com/feed/update/... #newlab #chromatin #epigenetics #milan #chromatindynamics www.gabrielelab.com
I am very excited to share that starting this summer, I will open my laboratory at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy! www.linkedin.com/feed/update/... #newlab #chromatin #epigenetics #milan #chromatindynamics www.gabrielelab.com
Unveiling the Secrets of Genome Architecture: Michele Gabriele’s Venture… | San Raffaele Telethon Institute for Gene Therapy (SR-Tiget)
📢 Exciting news: welcoming new #talents from the US! ✨
We are thrilled to announce that in the coming months, two new PIs will join SR-Tiget as Group Leaders, bringing their expertise from the United...
www.linkedin.com
April 23, 2025 at 12:37 PM
📢 New Lab Alert! 📢
I am very excited to share that starting this summer, I will open my laboratory at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy! www.linkedin.com/feed/update/... #newlab #chromatin #epigenetics #milan #chromatindynamics www.gabrielelab.com
I am very excited to share that starting this summer, I will open my laboratory at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy! www.linkedin.com/feed/update/... #newlab #chromatin #epigenetics #milan #chromatindynamics www.gabrielelab.com
Reposted by Michele Gabriele
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs.
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
www.biorxiv.org
April 3, 2025 at 2:43 PM
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs.
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
I'm proud to share that our modeling of #YY1 haploinsufficiency has just been published! www.nature.com/articles/s41... Using #organoids and #neurons we discovered that YY1 mutations affect the cross-talk between cells and also cause a non-cell autonomous phenotype in a cell-type specific manner.
Article Metrics - YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs | Molecular Psychiatry
www.nature.com
February 24, 2025 at 4:04 PM
I'm proud to share that our modeling of #YY1 haploinsufficiency has just been published! www.nature.com/articles/s41... Using #organoids and #neurons we discovered that YY1 mutations affect the cross-talk between cells and also cause a non-cell autonomous phenotype in a cell-type specific manner.
Finally out on @nature.com the last study from @jbuenrostro.bsky.social lab in which they developed a method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning that allows TF footprinting!! www.nature.com/articles/s41...
Multiscale footprints reveal the organization of cis-regulatory elements - Nature
We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.
www.nature.com
January 23, 2025 at 1:44 AM
Finally out on @nature.com the last study from @jbuenrostro.bsky.social lab in which they developed a method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning that allows TF footprinting!! www.nature.com/articles/s41...
Starting 2025 with a genome architecture paper about absolute quantification of looped states, lead by James Jusuf!
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: are generally rare (2.3%)
www.biorxiv.org/content/10.1...
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops:
www.biorxiv.org/content/10.1...
January 19, 2025 at 9:03 PM
Starting 2025 with a genome architecture paper about absolute quantification of looped states, lead by James Jusuf!