Other critical ?s

Do persistent virus/viral fragments or other molecules/pathways they induce (immune/inflammatory, redox shifts/oxidative stress/mitochondrial dysfunction/MCAS?) degrade collagen/other connective tissue components?

Might these findings represent an infection-associated EDS subset?

So please do what you can, at all times, to avoid infection/reinfection. Ask for formal olfactory testing (UPSIT or similar)! #SARSCoV2 may compromise your olfactory tracts (and, subsequently, your 🧠) even if you are unaware.

Olfactory Dysfunction After SARS-CoV-2
jamanetwork.com/journals/jam...

NB: ↓ sense of smell may be early sign of Alzheimer’s, Parkinson's. Olfactory tracts are key paths for pathogen entry into brain, where they may wreak neurodegenerative havoc.

And - this is key - abnormal olfactory tests were associated w/self-report of cognitive deficit, in both those reporting and in those not reporting olfactory problems in the context of SARS-CoV-2 infection.

But what was rather astonishing is that 66% of those *not* reporting change in/loss of sense of smell after infection *also* had abnormalities in olfactory testing.

Sweet; thank you.

Hoping for more opportunities to examine impact of illness duration in both LC and ME, as well as other IACCIs. Need multiomics that includes epigenetics as well as right and sufficiently-powered study design.

Thx 🥰

Thx Jaime ☮️

youtu.be/uqguD-NXyA8?...

👍👍👍

Agree - so many clues to adverse neurobehavioral sequelae, but they need to be followed up w/rigorous study designs.

Then the even harder part - getting anyone in public health leadership to take PPE/IAQ and prophylactic antivirals seriously.

What about kids’ neuromotor/cognitive development?

🥰