Matti Pronker
@mfpronker.bsky.social
Junior Director sdAb engineering at QVQ, structural biology, protein engineering, #cryoEM ❄️🔬, #crystallography 💎 - views are my own
It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop
September 12, 2025 at 1:18 PM
It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop
Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime
June 23, 2025 at 11:10 AM
Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime
Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!
May 23, 2025 at 1:28 PM
Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!
Cold yet pretty 😎
November 29, 2024 at 8:31 AM
Cold yet pretty 😎
The final reviewed version of our FLAG/anti-FLAG M2 structure paper is now out fully open access in the Journal of Molecular Biology: www.sciencedirect.com/science/arti...
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social
June 22, 2024 at 3:03 PM
The final reviewed version of our FLAG/anti-FLAG M2 structure paper is now out fully open access in the Journal of Molecular Biology: www.sciencedirect.com/science/arti...
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social
Many thanks to Wouter Beugelink, Els Sweep, Bert Janssen and @joostsnijder.bsky.social
Ever used a FLAG-tag and wondered how it is recognized by anti-FLAG M2? Check out our preprint where we determined a crystal structure of the complex: biorxiv.org/content/10.1... #structuralbiology #crystallography
March 28, 2024 at 12:07 PM
Ever used a FLAG-tag and wondered how it is recognized by anti-FLAG M2? Check out our preprint where we determined a crystal structure of the complex: biorxiv.org/content/10.1... #structuralbiology #crystallography
Vienna here I come! #nighttrain #IMP-biocenter
November 21, 2023 at 7:32 PM
Vienna here I come! #nighttrain #IMP-biocenter
Big improvements mentioned in the new #alphafold white paper, but still wrong models about half the time. I guess we aren't out of a job just yet...
November 1, 2023 at 10:57 AM
Big improvements mentioned in the new #alphafold white paper, but still wrong models about half the time. I guess we aren't out of a job just yet...
www.nature.com/articles/s41...
Beautiful work by Saunders et al on the coronavirus HKU1, that complements our recent finding that HKU1 spikes open up upon sialoglycan receptor binding (nature.com/articles/s4158…), allowing binding to a secondary protein host receptor, now identified as TMPRSS2!
Beautiful work by Saunders et al on the coronavirus HKU1, that complements our recent finding that HKU1 spikes open up upon sialoglycan receptor binding (nature.com/articles/s4158…), allowing binding to a secondary protein host receptor, now identified as TMPRSS2!
October 25, 2023 at 6:26 PM
www.nature.com/articles/s41...
Beautiful work by Saunders et al on the coronavirus HKU1, that complements our recent finding that HKU1 spikes open up upon sialoglycan receptor binding (nature.com/articles/s4158…), allowing binding to a secondary protein host receptor, now identified as TMPRSS2!
Beautiful work by Saunders et al on the coronavirus HKU1, that complements our recent finding that HKU1 spikes open up upon sialoglycan receptor binding (nature.com/articles/s4158…), allowing binding to a secondary protein host receptor, now identified as TMPRSS2!
It's silly how satisfying this is to me...
October 16, 2023 at 1:37 PM
It's silly how satisfying this is to me...
And it's out! Check out our paper in @Nature on the human coronavirus HKU1 spike binding to a sialoglycan receptor, leading to spike opening via large conformational changes. Massive thanks to @danielhurdiss.bsky.social, @raouljdegroot.bsky.social and all co-authors!
nature.com/articles/s41...
nature.com/articles/s41...
October 4, 2023 at 3:45 PM
And it's out! Check out our paper in @Nature on the human coronavirus HKU1 spike binding to a sialoglycan receptor, leading to spike opening via large conformational changes. Massive thanks to @danielhurdiss.bsky.social, @raouljdegroot.bsky.social and all co-authors!
nature.com/articles/s41...
nature.com/articles/s41...