mesoSPIM: Clear Images. Big samples. Open source.
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mesospim.bsky.social
mesoSPIM: Clear Images. Big samples. Open source.
@mesospim.bsky.social
170 followers 6 following 30 posts
Light-sheet microscopes for large samples. Open source hardware and software. Run by @nvladimus.bsky.social and @voigtvision.bsky.social

Overview: www.mesospim.org
Mailing list: http://eepurl.com/hPBRhj
Forum: forum.image.sc/tag/mesospim
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mesospim.bsky.social
The 10 Years of #mesoSPIM Symposium was a blast! 🔟🎂The excitement was palpable, and we were all inspired. Three days flew by fast! Thanks to all the attendees, speakers, organizing team, and our sponsors for making it such a memorable event! Let's shape the next 10y of microscopy together! 💪❤️🔬
October 16, 2025 at 3:43 PM
mesospim.bsky.social
Job opportunity at the University of Zurich! 📢

We are looking for a 𝐋𝐚𝐛𝐨𝐫𝐚𝐭𝐨𝐫𝐲 𝐓𝐞𝐜𝐡𝐧𝐢𝐜𝐢𝐚𝐧 / 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐀𝐬𝐬𝐢𝐬𝐭𝐚𝐧𝐭 (𝟒𝟎%) to join our Microscopy Innovation Platform (MIP), an open-source initiative focused on advancing and making light-sheet and multiphoton microscopy accessible to researchers.

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October 10, 2025 at 8:58 AM
mesospim.bsky.social
Is it possible to stain specific proteins and cell types in old formalin-fixed human tissues and make them transparent for light-sheet imaging and clinical 3D diagnostics?

🧵 1/3
Image presenting two of the speakers for the 10 Years of mesoSPIM symposium. Background of the image is a microscopy picture showing blood vessels in magenta and glial cells in cyan on a black field. On the top left, the photo of the first speaker is contained in a white-rimmed circle. On the top right the text reads: "Hei Ming Lai, The Chinese University of Hong Kong, HK" followed by the talk title "Customizing mesoSPIM-based workflows for clinical 3D tissue Diagnostics". On the lower part of the image, the second speaker is presented in a specular manner. On the lower left, text reads “Anna Maria Reuss, University Hospital, Zurich, Switzerland”, followed by the talk title “aDISCO - A Broadly Applicable Method for 3D Microscopy of Archival Paraffin-Embedded Human Tissues”. On the lower left, the photo of the second speaker is contained in a white-rimmed circle. On the bottom right it reads “10 Years of mesoSPIM Symposium”
August 27, 2025 at 10:32 AM
mesospim.bsky.social
Final program of the 10-year #mesoSPIM2025 Anniversary Symposium, October 13-15 in Zurich! Amazing lineup of speakers: biologists, physicists, developers, computer scientists and industry experts! Join us to learn, present, and connect! Registration until Sept. 15. www.adabd.uzh.ch/en/events/me...
August 22, 2025 at 3:36 PM
mesospim.bsky.social
How to image across scales from organs to synapses, unravel biological mechanisms and handle massive data?
Learn more from @adamkglaser.bsky.social, senior scientist at the Allen Institute and the lead developer of #ExA-SPIM technique, at the #mesoSPIM2025 Symposium, Oct 13-15.
Image presenting one of the speakers for the 10 Years of mesoSPIM symposium. Background of the image is a microscopy picture showing blood vessels in magenta and glial cells in cyan on a black field. On the left, the photo of the speaker is contained in a white-rimmed circle. On the right the text reads: "Adam Glaser, Allen Institute, WA, USA" followed by the talk title "New technologies for mapping centimeter scale tissues with nanoscale resolution". On the bottom right it reads “10 Years of mesoSPIM Symposium”
August 20, 2025 at 11:38 AM
mesospim.bsky.social
💥How can light-sheet help reveal dark matter?💥
Join Prof. Laura Baudis @lbaudis.bsky.social at #mesoSPIM Symposium, Oct 13–15 in Zurich or online, to see how light-sheet fluorescence microscopy 🔬 is used to image nuclear ☢️ recoil tracks to detect elusive particles!
Register now: t.uzh.ch/1Ss
mage presenting one of the speakers for the 10 Years of mesoSPIM symposium. Background of the image is a microscopy picture showing blood vessels in magenta and glial cells in cyan on a black field. On the left, the photo of the speaker is contained in a white-rimmed circle, on the right text reads: "Laura Baudis, University of Zurich, Switzerland" followed by the talk title "Probing dark matter and neutrinos with light sheet microscopy". On the bottom right reads "10 Years of mesoSPIM Symposium”
August 18, 2025 at 9:28 AM
mesospim.bsky.social
We’re excited to welcome @kevin-dean.bsky.social to the #mesoSPIM2025 Symposium! Explore his innovations in Multiscale Cleared-Tissue Axially Swept Light-Sheet Microscopy for imaging from organ to subcellular levels.
🗺️Oct 13–15 | Zurich & hybrid
Interested? Register now: t.uzh.ch/1Ss
August 12, 2025 at 9:50 AM
mesospim.bsky.social
🎉 Call for Abstracts! 🎉
Abstract deadline approaching! 10 years of #mesoSPIM initiative – join us at the symposium for talks, demos & posters on microscopy, tissue clearing, and data analysis!
📆 October 13-15, 2025
🗺️ Zurich, Switzerland, but also online.
www.adabd.uzh.ch/en/events/me...
July 3, 2025 at 10:27 AM
mesospim.bsky.social
🎉 Call for Abstracts! 🎉
We’re celebrating 10 years of #mesoSPIM #opensource initiative – join us at the symposium for talks, demos & posters on open-source light-sheet microscopy, tissue clearing, and imaging!
Dates: October 13-15, 2025
Location: Zurich, Switzerland
Registration: ema.uzh.ch/R7YRN
June 12, 2025 at 9:15 AM
mesospim.bsky.social
Did you know that Universite Paris Saclay has its own Benchtop #mesoSPIM? Interdisciplinary team lead by @christellelangevin.bsky.social has built their own setup, the first in France, and organized an inauguration symposium! Cleared baby sturgeon or trout? They have it! French bioimaging is strong!
June 7, 2025 at 11:23 AM
mesospim.bsky.social
Want to learn about #mesoSPIM imaging initiative and network with microscopy and data analysis experts? Come to Paris-Saclay on June 6-th! Meet our team there! Registration is still open (and free)! mesospim-upas.sciencesconf.org
April 29, 2025 at 9:35 AM
mesospim.bsky.social
New release of #mesoSPIM control software! Major bug fixes and performance improvement. github.com/mesoSPIM/mes...
### Performance :rocket: - implementation of time lapse function via script. See example script at `mesoSPIM/scripts/timelapse.py` for details. - images can now be displayed at full resolution during either live mode or acquisition, with no performance penalty. Deprecated config parameters: ``` python 'camera_display_live_subsampling': 2, 'camera_display_acquisition_subsampling': 2, ``` to enjoy full-resolution image in real time. The corresponding GUI elements for controlling the downsampling were removed. ### Bugfixes :bug: - duplication of sub-stacks while writing large H5 files (>0.5 TB) and freezing at the end of acquisition. Fixed by replacing signal/slot mechanism for CameraWindow image update to deque mechanism. Boosted performance and stability. - `MAX` projection is always on by default, if the dataset is asvaed in TIFF or RAW format. No need to check the box in the Image Processing Wizard. This generates maximum intensity projection as TIFF file for each stack in the acquisition list. - explicit initialization of the first raw in Acquisition Manager, to avoid undefined GUI widget states.
March 10, 2025 at 10:37 AM
mesospim.bsky.social
Some good news: 3 new Benchtop #mesoSPIM are being built!
Scientists in China, USA, and Czech Republic are building the beautiful open-source beasts for their research.
South America, what are you waiting for? Australia? Greenland?
mesospim.org/setups/
February 14, 2025 at 2:01 PM
mesospim.bsky.social
New experimental feature: timelapse for #mesoSPIM! Because why not? You can now image live specimen, such as developing organisms. Checkout this SW version at:
github.com/mesoSPIM/mes...
and let us know how it works for you. Be brave!
February 5, 2025 at 3:33 PM
mesospim.bsky.social
The #mesoSPIM project highlights in 2024, The Year of Benchtop. mailchi.mp/dced0daca419... (image courtesy Tchern Lenn)
January 20, 2025 at 10:10 AM