Sarah Merkling
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merklinglab.bsky.social
Sarah Merkling
@merklinglab.bsky.social
We are all about mosquitoes, viruses and single cells!
Insect Infection and Immunity - Merkling Lab
@CNRS.fr @Pasteur.fr @ERC.europa.eu
#newPI #DiversityEquityInclusion #ally 🏳️‍🌈🏳️‍⚧️
https://aedes-cell-atlas.pasteur.cloud/
August 28, 2025 at 7:42 AM
Yes! This is cytochrome P4503A4 - it is a very large family and their activity spans from detoxification, metabolism and many more cellular processes. In our case, the exact mechanism linking our P450 with dengue virus is unknown - might be metabolism (my first guess), or something else ...
August 19, 2025 at 2:25 PM
Thank you Alain!
August 19, 2025 at 2:21 PM
Thank you Olaya !
August 19, 2025 at 2:21 PM
Thank you ! So much more work to do indeed :)
August 19, 2025 at 2:20 PM
This was one of the most exciting, exploratory, long and difficult project I ever got to work on and I thank everyone who contributed, shared ideas and asked questions about it at meetings. Thanks to our funders @pasteur.fr @agencerecherche.bsky.social for their continuous support !
August 18, 2025 at 12:05 PM
It also raises new questions about the role of metabolism in DENV infection and the unexplored/mysterious link between DENV susceptibility and insecticide resistance. (2/3)
August 18, 2025 at 12:05 PM
Congratulations on getting the poster prize !! 🥳
Also very nice meeting you at the conference :)
May 19, 2025 at 6:36 PM