Mehershad Wadia
@mehershadw.bsky.social
Neuroscientist, Writer, Comedian(?)
🔬Hilliard Lab, University of Queensland
🔬Hilliard Lab, University of Queensland
OSP-1 could potentially become a target for future treatments protecting neurons from oxidative insults & these findings could help treat conditions such as stroke.
Massive congratulations again to Alessandra, Massimo and fellow authors for their amazing and inspiring work🙌👇
doi.org/10.1038/s414...
Massive congratulations again to Alessandra, Massimo and fellow authors for their amazing and inspiring work🙌👇
doi.org/10.1038/s414...
OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress - Nature Communications
How oxidative stress impacts neurons is poorly understood. Here the authors reveal that overactivation of autophagy following oxidative stress contributes to neuronal death and discover a protective f...
nature.com
January 19, 2025 at 8:48 AM
OSP-1 could potentially become a target for future treatments protecting neurons from oxidative insults & these findings could help treat conditions such as stroke.
Massive congratulations again to Alessandra, Massimo and fellow authors for their amazing and inspiring work🙌👇
doi.org/10.1038/s414...
Massive congratulations again to Alessandra, Massimo and fellow authors for their amazing and inspiring work🙌👇
doi.org/10.1038/s414...
As the ER interacts with lysosomes, we show that OSP-1 mutants have altered lysosome clustering within neurons, which is known to affect autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
January 19, 2025 at 8:48 AM
As the ER interacts with lysosomes, we show that OSP-1 mutants have altered lysosome clustering within neurons, which is known to affect autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
To understand how exactly OSP-1 protects C. elegans neurons, we tried to visualise where the molecule functions. We found that OSP-1 localised to the ER membrane and caused rearrangement of the ER.
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
January 19, 2025 at 8:48 AM
To understand how exactly OSP-1 protects C. elegans neurons, we tried to visualise where the molecule functions. We found that OSP-1 localised to the ER membrane and caused rearrangement of the ER.
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
Neurons were on a 'break':
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
January 19, 2025 at 8:48 AM
Neurons were on a 'break':
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!