Mehershad Wadia
@mehershadw.bsky.social
Neuroscientist, Writer, Comedian(?)
🔬Hilliard Lab, University of Queensland
🔬Hilliard Lab, University of Queensland
I'll be MCing the wonderful Pint of Science festival featuring some outstanding scientists!
📍 Easy Times Brewing Co, Brisbane
🗓️ 19th to 21st May!
Come along for an evening full of amazing science brewing right here in Brisbane!
📍 Easy Times Brewing Co, Brisbane
🗓️ 19th to 21st May!
Come along for an evening full of amazing science brewing right here in Brisbane!
May 16, 2025 at 4:30 PM
I'll be MCing the wonderful Pint of Science festival featuring some outstanding scientists!
📍 Easy Times Brewing Co, Brisbane
🗓️ 19th to 21st May!
Come along for an evening full of amazing science brewing right here in Brisbane!
📍 Easy Times Brewing Co, Brisbane
🗓️ 19th to 21st May!
Come along for an evening full of amazing science brewing right here in Brisbane!
As the ER interacts with lysosomes, we show that OSP-1 mutants have altered lysosome clustering within neurons, which is known to affect autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
January 19, 2025 at 8:48 AM
As the ER interacts with lysosomes, we show that OSP-1 mutants have altered lysosome clustering within neurons, which is known to affect autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
We show that autophagy inhibition conferred similar protection & propose that OSP-1 functions as a negative regulator of autophagy.
To understand how exactly OSP-1 protects C. elegans neurons, we tried to visualise where the molecule functions. We found that OSP-1 localised to the ER membrane and caused rearrangement of the ER.
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
January 19, 2025 at 8:48 AM
To understand how exactly OSP-1 protects C. elegans neurons, we tried to visualise where the molecule functions. We found that OSP-1 localised to the ER membrane and caused rearrangement of the ER.
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
(Mutated OSP-1 reduced ER branching in the proximal axonal segment)👇
Neurons were on a 'break':
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
January 19, 2025 at 8:48 AM
Neurons were on a 'break':
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
Using targeted ROS generation, we saw that C. elegans worms with a mutated OSP-1 (vd60) had higher neuronal damage & reduced lifespan.
Interestingly, providing OSP-1 to rodent & human cultures protected these mammalian cells against oxidative insults!
NEW Paper:
If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS
Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇
If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS
Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇
January 19, 2025 at 8:48 AM
NEW Paper:
If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS
Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇
If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS
Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇