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MedComm

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Size Matters: Small Circulating Tumor Cells Indicate Worse Therapy Response in Breast Cancer doi.org/10.1002/mco2...

#CellMorphology #CirculatingTumorCells #FlowCytometry #TherapyResponse

November 14, 2025 at 3:45 AM

MedComm

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#Article in #MedComm
Targeting the Liquid–Liquid Separation Region of c-Maf for Treating Chromosomal Translocations in Multiple Myeloma doi.org/10.1002/mco2...

#BenzoylBenzoicAcid #cMaf #ChromosomalTranslocation #LLPS #MultipleMyeloma #IDRs #BBA

Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple Myeloma

Targeting the liquid-liquid separation region of c-Maf for treating pathogenic chromosomal translocations in multiple myeloma. c-Maf promotes cell proliferation by forming liquid–liquid phase separat....

doi.org

November 14, 2025 at 3:39 AM

MedComm

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#Review in #MedComm
The Gut‒Liver Axis in Liver Disease: Molecular Mechanisms and Therapeutic Targets doi.org/10.1002/mco2...

#GutLiverAxis #dysbiosis #IntestinalBarrierDysfunction #LiverDisease #pathogenesis

The Gut‒Liver Axis in Liver Disease: Molecular Mechanisms and Therapeutic Targets

The global burden of liver disease is increasing, and gut-liver axis dysregulation is a key driver. This article explains its mechanisms in various liver diseases and explores targeted therapeutic st....

doi.org

November 14, 2025 at 3:35 AM

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Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis doi.org/10.1002/mco2...

#ATP #mitochondria #MycobacteriumTuberculosis #Mtb #StressGranule #tuberculosis

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis

During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial co...

doi.org

November 14, 2025 at 3:05 AM

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#Exosomal Long Interspersed Nuclear Element-1 Analytes Discriminate Histologic Subtypes, Sex, and Clinicopathological Characteristics of Patients with Non-Small Cell Lung #Cancer doi.org/10.1002/mco2..., studied by a team from @CenterTexas

#biomarker

Exosomal Long Interspersed Nuclear Element‐1 Analytes Discriminate Histologic Subtypes, Sex, and Clinicopathological Characteristics of Patients with Non‐Small Cell Lung Cancer

Exosomal long interspersed nuclear element-1 (LINE-1) analytes exhibit distinct expression profiles across histologic subtypes of non-small cell lung cancer (NSCLC) and demonstrate significant associ...

doi.org

November 14, 2025 at 2:53 AM

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Quantitative Computed Tomographic Clusters in C-BIOPRED Asthma #Cohort: Association with Sputum Proteomics doi.org/10.1002/mco2...

#AirflowObstruction #asthma #AirwayRemodeling #qCT #proteomics

Quantitative Computed Tomographic Clusters in C‐BIOPRED Asthma Cohort: Association with Sputum Proteomics

Using quantitative computed tomography (qCT) clustering in the C-BIOPRED asthma cohort of 239 patients, four distinct phenotypes were identified based on airway dimensions, lung volumes, and densitom...

doi.org

November 14, 2025 at 2:36 AM

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Fusobacterium nucleatum in Health and Disease doi.org/10.1002/mco2...

#FusobacteriumNucleatum #health #inflammation #malignancy #microbiota

Fusobacterium nucleatum in Health and Disease

Fusobacterium nucleatum (Fn), an oral commensal and opportunistic pathogen, primarily colonizes the oral cavity. It contributes to multiple nonmalignant diseases and cancers—especially colorectal can...

doi.org

November 14, 2025 at 2:31 AM

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Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions doi.org/10.1002/mco2...

#ADAMTS13 #adipokine #pancreas #PDAC #PeripancreaticAdipose #vascularization

Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions

Allmang et al. demonstrated that ADAMTS13 is overexpressed in PDAC, associated with prolonged survival and reduced vascular density. Knockout of ADAMTS13 in PDAC cells led to a decrease in migration ...

doi.org

November 14, 2025 at 2:28 AM

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Trained Immunity in Health and Disease doi.org/10.1002/mco2...

#EpigeneticInheritance #Immunotherapy #ImmuneCell #MetabolicReprogramming #TrainedImmunity

Trained Immunity in Health and Disease

Growth and timescale of medical publications on trained immunity and its related health and disease. This figure illustrates the number of published papers over time, from 2000 to 2025 (by August 14,...

doi.org

November 14, 2025 at 2:09 AM

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First-Line Third-Generation #EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR-Mutated Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis doi.org/10.1002/mco2...

#MetaAnalysis #NSCLC #TKI #FirstLine #TRAE #Monotherapy

First‐Line Third‐Generation EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR‐Mutated Non‐Small Cell Lung Cancer: A Systematic Review and Network Meta‐Analysis

Third-generation EGFR-TKIs are the current first-line standard for advanced EGFR-mutated NSCLC. While all improve PFS versus first-generation TKIs, no significant PFS or ORR differences exist among t...

doi.org

November 14, 2025 at 2:04 AM

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#Review in #MedComm_Biomatrials_and_Applications
Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross-Pathogen Diagnostic Universality doi.org/10.1002/mba2...

#cross_pathogen #diagnostic #modular #nanosensing #platforms #nanobiosensor

November 14, 2025 at 1:50 AM

MedComm

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🎉Congratulations！

In the recently released JCR Impact Factor 2024, MedComm maintained an IF of 10.7, placing it in the Q1 category for Medicine, Research & Experimental, ranking 14/195. Welcome to submit your next manuscripts to MedComm!

#JCR2025 #TrustedJournals #ImpactFactor

November 7, 2025 at 8:36 AM

MedComm

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#Article in #MedComm
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy doi.org/10.1002/mco2...

#AxonalDamage #biomarker #CognitiveDysfunction #TIPS #GFAP

Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy

Hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) insertion constitutes a frequent and severe complication, however, biomarkers are currently scarce. The results ...

doi.org

November 7, 2025 at 8:23 AM

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Chidamide (a Histone Deacetylase Inhibitor) Plus Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Phase Ib Trial doi.org/10.1002/mco2...
#Clinicaltrial #EpigeneticRegulation #HistoneDeacetylase #mCRPC

Chidamide (a Histone Deacetylase Inhibitor) Plus Abiraterone in Metastatic Castration‐Resistant Prostate Cancer (mCRPC): A Phase Ib Trial

Metastatic castration-resistant prostate cancer (mCRPC) remains challenging. This Phase Ib trial tested chidamide, a selective HDAC inhibitor, plus abiraterone in 18 patients. The regimen was well to...

doi.org

November 7, 2025 at 8:21 AM

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Artificial Intelligence for the Diagnosis and Management of Cancers: Potentials and Challenges doi.org/10.1002/mco2...

#ArtificialIntelligence #AI #cancer #CancerDiagnosis #PrognosisPrediction #personalized #therapy

Artificial Intelligence for the Diagnosis and Management of Cancers: Potentials and Challenges

Artificial intelligence (AI) is a rising star in the field of medicine, avoiding misdiagnosis by human negligence, reducing the workload of doctors, and aiding clinicians in decision-making. AI can i...

doi.org

November 7, 2025 at 8:20 AM

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Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential doi.org/10.1002/mco2...

#BiologicalFunction #Classification #development #DendriticCell #Origin #TherapeuticPotential

Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential

This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/present...

doi.org

November 7, 2025 at 8:20 AM

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SARS-CoV-2 Spike Protein as a Target of the COVID-19 Vaccine Disrupts Insulin Signaling in Type 2 Diabetes doi.org/10.1002/mco2...

#COVID_19 #diabetes #InsulinSensitivity #SARS_CoV_2
#Vaccine #Protein #Target

SARS‐CoV‐2 Spike Protein as a Target of the COVID‐19 Vaccine Disrupts Insulin Signaling in Type 2 Diabetes

SARS Cov-2 spike protein disrupts insulin signaling in type 2 diabetes as a target of the COVID-19 vaccine in subject with type 2 diabetes (T2D), while metformin improved the insulin signaling variat...

doi.org

November 7, 2025 at 8:19 AM

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Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism doi.org/10.1002/mco2...

#MMP #prohibitin1 #VDAC1 #probe #BindingIdentification