MedChemExpress
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Inhibitors ＆ Agonists | Proteins | Drug Screening Platform
Inhibitors ＆ Agonists | Proteins | Drug Screening Platform
🚀From Bench to Paper | MUC1-C: Key Target for TKI-Refractory #NSCLC
MUC1-C drives NSCLC #osimertinib resistance via STAT1/IFN signaling and “inflammatory memory”. The M1C ADC effectively targets #MUC1C–dependent resistant cells—offering new hope for refractory NSCLC. #Oncology
MUC1-C drives NSCLC #osimertinib resistance via STAT1/IFN signaling and “inflammatory memory”. The M1C ADC effectively targets #MUC1C–dependent resistant cells—offering new hope for refractory NSCLC. #Oncology
December 5, 2025 at 9:02 PM
🚀From Bench to Paper | MUC1-C: Key Target for TKI-Refractory #NSCLC
MUC1-C drives NSCLC #osimertinib resistance via STAT1/IFN signaling and “inflammatory memory”. The M1C ADC effectively targets #MUC1C–dependent resistant cells—offering new hope for refractory NSCLC. #Oncology
MUC1-C drives NSCLC #osimertinib resistance via STAT1/IFN signaling and “inflammatory memory”. The M1C ADC effectively targets #MUC1C–dependent resistant cells—offering new hope for refractory NSCLC. #Oncology
🔥Hot Off the Press | A study in #JACS: engineered #PROTAC2 that degrades multiple #vRNP components and shows
🌟Potent, long-lasting #antiviral activity
🌟Broad-spectrum efficacy across #H1N1, #H3N2, #H9N2, #H5N6, and #drug-resistant strains, both in vitro and in vivo.
🌟Potent, long-lasting #antiviral activity
🌟Broad-spectrum efficacy across #H1N1, #H3N2, #H9N2, #H5N6, and #drug-resistant strains, both in vitro and in vivo.
December 5, 2025 at 6:02 PM
🔥Hot Off the Press | A study in #JACS: engineered #PROTAC2 that degrades multiple #vRNP components and shows
🌟Potent, long-lasting #antiviral activity
🌟Broad-spectrum efficacy across #H1N1, #H3N2, #H9N2, #H5N6, and #drug-resistant strains, both in vitro and in vivo.
🌟Potent, long-lasting #antiviral activity
🌟Broad-spectrum efficacy across #H1N1, #H3N2, #H9N2, #H5N6, and #drug-resistant strains, both in vitro and in vivo.
📰New & Featured | Recent research implies that #astrocytes have roles in behavior, #memory, and #brain function
🌟Regulation of brain #metabolism and #homeostasis
🌟Influences neural circuits
🌟Supports brain health e.g. modulation of how neurons communicate
🌟Regulation of brain #metabolism and #homeostasis
🌟Influences neural circuits
🌟Supports brain health e.g. modulation of how neurons communicate
December 5, 2025 at 4:01 PM
📰New & Featured | Recent research implies that #astrocytes have roles in behavior, #memory, and #brain function
🌟Regulation of brain #metabolism and #homeostasis
🌟Influences neural circuits
🌟Supports brain health e.g. modulation of how neurons communicate
🌟Regulation of brain #metabolism and #homeostasis
🌟Influences neural circuits
🌟Supports brain health e.g. modulation of how neurons communicate
🔥Hot Off the Press | 🌡️How do #plants sense #heat?
A new #Cell study uncovers a stepwise #thermo-decoding mechanism:
🟠 Heat remodels membrane lipids
🟠 Lipid shifts trigger intracellular signaling
🟠 A multi-layer cascade activates protective responses
#PlantScience #HeatStress
A new #Cell study uncovers a stepwise #thermo-decoding mechanism:
🟠 Heat remodels membrane lipids
🟠 Lipid shifts trigger intracellular signaling
🟠 A multi-layer cascade activates protective responses
#PlantScience #HeatStress
December 4, 2025 at 10:00 PM
🔥Hot Off the Press | 🌡️How do #plants sense #heat?
A new #Cell study uncovers a stepwise #thermo-decoding mechanism:
🟠 Heat remodels membrane lipids
🟠 Lipid shifts trigger intracellular signaling
🟠 A multi-layer cascade activates protective responses
#PlantScience #HeatStress
A new #Cell study uncovers a stepwise #thermo-decoding mechanism:
🟠 Heat remodels membrane lipids
🟠 Lipid shifts trigger intracellular signaling
🟠 A multi-layer cascade activates protective responses
#PlantScience #HeatStress
📰New & Featured | A study from #Cell discovered clear #proteome asymmetries between sister #blastomeres as early as the #2-cell stage
🔸#Alpha-Beta asymmetry is associated with developmental potential
🔸#Fertilization is a trigger for proteomic symmetry breaking in the #zygote
🔸#Alpha-Beta asymmetry is associated with developmental potential
🔸#Fertilization is a trigger for proteomic symmetry breaking in the #zygote
December 4, 2025 at 7:00 PM
📰New & Featured | A study from #Cell discovered clear #proteome asymmetries between sister #blastomeres as early as the #2-cell stage
🔸#Alpha-Beta asymmetry is associated with developmental potential
🔸#Fertilization is a trigger for proteomic symmetry breaking in the #zygote
🔸#Alpha-Beta asymmetry is associated with developmental potential
🔸#Fertilization is a trigger for proteomic symmetry breaking in the #zygote
📰New & Featured | A study in #Cell reported that live-attenuated #herpes #zoster (HZ) #vaccination might reduce mild cognitive impairment diagnoses and death caused by #dementia
🔸The beneficial effect exists amongst people with advanced dementia
#HerpesZosterVaccination
🔸The beneficial effect exists amongst people with advanced dementia
#HerpesZosterVaccination
December 3, 2025 at 10:01 PM
📰New & Featured | A study in #Cell reported that live-attenuated #herpes #zoster (HZ) #vaccination might reduce mild cognitive impairment diagnoses and death caused by #dementia
🔸The beneficial effect exists amongst people with advanced dementia
#HerpesZosterVaccination
🔸The beneficial effect exists amongst people with advanced dementia
#HerpesZosterVaccination
🚀 From Bench to Paper | Aerolysin-Producing Aeromonas & #UlcerativeColitis
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
December 1, 2025 at 8:01 PM
🚀 From Bench to Paper | Aerolysin-Producing Aeromonas & #UlcerativeColitis
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
🔥Hot Off the Press | A study in #Cell reports a lytic cell death mechanism triggered by innate immune system + metabolic disruption
🔸#BAX/BAK1/BID-dependent oxidative stress ➡️#Mitoxyperiosis: oxidative damage➡️#Mitoxyperilysis: membrane lysis and cell death regulated by mTORC2
🔸#BAX/BAK1/BID-dependent oxidative stress ➡️#Mitoxyperiosis: oxidative damage➡️#Mitoxyperilysis: membrane lysis and cell death regulated by mTORC2
December 1, 2025 at 6:31 PM
🔥Hot Off the Press | A study in #Cell reports a lytic cell death mechanism triggered by innate immune system + metabolic disruption
🔸#BAX/BAK1/BID-dependent oxidative stress ➡️#Mitoxyperiosis: oxidative damage➡️#Mitoxyperilysis: membrane lysis and cell death regulated by mTORC2
🔸#BAX/BAK1/BID-dependent oxidative stress ➡️#Mitoxyperiosis: oxidative damage➡️#Mitoxyperilysis: membrane lysis and cell death regulated by mTORC2
🚀From Bench to Paper | How do non-LTR retrotransposons insert genes stably?
🧬A #Science study shows #genome-primed cDNA synthesis is key. MedChemExpress compounds #ART558 #CD437 #Adarotene #VE821 #Ceralasertib #CX5461 #Nutlin3a were used to probe the mechanism.
🧬A #Science study shows #genome-primed cDNA synthesis is key. MedChemExpress compounds #ART558 #CD437 #Adarotene #VE821 #Ceralasertib #CX5461 #Nutlin3a were used to probe the mechanism.
December 1, 2025 at 5:02 PM
🚀From Bench to Paper | How do non-LTR retrotransposons insert genes stably?
🧬A #Science study shows #genome-primed cDNA synthesis is key. MedChemExpress compounds #ART558 #CD437 #Adarotene #VE821 #Ceralasertib #CX5461 #Nutlin3a were used to probe the mechanism.
🧬A #Science study shows #genome-primed cDNA synthesis is key. MedChemExpress compounds #ART558 #CD437 #Adarotene #VE821 #Ceralasertib #CX5461 #Nutlin3a were used to probe the mechanism.
🔥Hot Off the Press | GRAPE: #DirectedEvolution in #Plants
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
December 1, 2025 at 4:00 PM
🔥Hot Off the Press | GRAPE: #DirectedEvolution in #Plants
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek
👩Maternal Cholesterol & Baby’s #Heart Health
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
November 28, 2025 at 9:15 PM
👩Maternal Cholesterol & Baby’s #Heart Health
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
Low maternal cholesterol ↑CHD risk (5,041-family study).
Mouse models & CYP51A1 variant confirm the link.
Maternal cholesterol supplements can lower #CHD risk.
Better maternal-fetal health ahead!
#MaternalHealth #Genetics
🚀From Bench to Paper | Unlocking the Secrets of Social Memory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
November 28, 2025 at 8:30 PM
🚀From Bench to Paper | Unlocking the Secrets of Social Memory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
Social interaction triggers #NLG1 proteolysis to generate NLG1-CTD, strengthening synapses and supporting social memory. Blocking this process impairs memory, while peptides can rescue it.
#Neuroscience #SocialMemory
📰New & Featured | A #Nature study reveals that #IL-1β promotes social withdrawal during sickness in #animals by regulating #IL-1R1-expressing neurons in the dorsal raphe nucleus (#DRN).
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
November 28, 2025 at 6:02 PM
📰New & Featured | A #Nature study reveals that #IL-1β promotes social withdrawal during sickness in #animals by regulating #IL-1R1-expressing neurons in the dorsal raphe nucleus (#DRN).
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
👉Inhibition of #IL-1R1 prevents self-imposed social isolation during systemic #inflammation
🔥Hot Off the Press | #ADHD diagnoses are on the rise
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
November 28, 2025 at 4:00 PM
🔥Hot Off the Press | #ADHD diagnoses are on the rise
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
🔸Last year in the US, over 11% of children were diagnosed with ADHD, compared to 8% in 2003.
🌟ADHD should be better supported
💡The next step for scientists is to discover biological markers to improve diagnosis
🐘Happy Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
November 28, 2025 at 3:02 AM
🐘Happy Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#Thanksgiving
📰New & Featured | A study in #Nature: #POU2F3 forms a DNA-dependent complex with #OCA-T1 or #OCA-T2
🔸Suppression of POU2F3/OCA-T1 results in tuft cell-like #SCLC xenograft regression
🔸Vulnerabilities in #POU2F3-OCA-T complex that might be susceptible to therapeutic disruption
🔸Suppression of POU2F3/OCA-T1 results in tuft cell-like #SCLC xenograft regression
🔸Vulnerabilities in #POU2F3-OCA-T complex that might be susceptible to therapeutic disruption
November 27, 2025 at 11:01 PM
📚#Microglia in #AD switch to pro-inflammatory glycolysis under Aβ, become energy-depleted, and impair phagocytosis. Linked to LDAM and TREM2/APOE. Potential interventions: glycolytic boost, mitochondrial recovery, lipid clearance, NLRP3 inhibition.
🔗https://ow.ly/OZOj50XyvGo
🔗https://ow.ly/OZOj50XyvGo
November 27, 2025 at 10:15 PM
📚#Microglia in #AD switch to pro-inflammatory glycolysis under Aβ, become energy-depleted, and impair phagocytosis. Linked to LDAM and TREM2/APOE. Potential interventions: glycolytic boost, mitochondrial recovery, lipid clearance, NLRP3 inhibition.
🔗https://ow.ly/OZOj50XyvGo
🔗https://ow.ly/OZOj50XyvGo
🔥Hot Off the Press | New in #ACS: #Leishmania major exploits its metalloprotease #GP63 to stabilize parasitophorous vacuoles.
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
November 26, 2025 at 7:02 PM
🔥Hot Off the Press | New in #ACS: #Leishmania major exploits its metalloprotease #GP63 to stabilize parasitophorous vacuoles.
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
🔸GP63 recruits #PIST to vacuoles
🔸Suppresses #caspase-3 → preserves #Golgin160-PIST complex
🔸Modulates #autophagy via #PIST-Beclin1 colocalization
🐘Happy #Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
November 26, 2025 at 3:15 PM
🐘Happy #Thanksgiving from MedChemExpress!
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
🍂We’re extra thankful for all our customers, collaborators and colleagues, who make our journey so special. Let’s dance with Magic Cece! May your turkey be juicy, your desserts be sweet, and your day be full of laughter, family, and friends! 🥧
#HappyHolidays
🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.
November 26, 2025 at 3:59 AM
🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.
📢Join Our Upcoming Webinar | Advances in #Pancreatic #Cancer Therapy
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
November 26, 2025 at 2:29 AM
📢Join Our Upcoming Webinar | Advances in #Pancreatic #Cancer Therapy
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.