MS
mdstor.bsky.social
MS
@mdstor.bsky.social
🇦🇷Biólogo bohemio en el exilio virtual.
🇺🇸Cell nucleus biologist in the virtual exile.
🔬Transcription factors, genome structure, nuclear architecture, biomolecular condensates.
🗣️Views are my own.
4) We also show a proof-of-principle application of OptoLoop by interrogating the role of long-range looping between the human telomerase gene TERT and the telomere. Out coupled RNA/DNA-FISH analysis supports a role of telomere-TERT looping for TERT regulation at the single-cell level.
November 10, 2025 at 4:51 PM
3) We demonstrate that OptoLoop can drive the induction of a de novo chromatin loop between two genomically distant, repetitive DNA loci, as fast as even after 90 min of light exposure. We obtained single-cell and single-allele information by assessing contacts by DNA-FISH.
November 10, 2025 at 4:51 PM
2) OptoLoop consists of a fusion between dCas9 and the light-dependent oligomerizing protein CRY2. Genome structure can be manipulated by inducing specific chromatin loops by light. dCas9 tethers the fusion protein to target sites and CRY2:CRY2 interactions stabilize the chromatin contacts
November 10, 2025 at 4:51 PM
Para mi es más onda Jack Nicholson
September 10, 2025 at 3:07 PM
What do you mean by 'prone'? Left-wing has ruled Brazil over 15 out of the last 22 years. There is alternation, like in the US, for example.

This is the homicide rates in the American continent. Brazil, Colombia, Mexico with high rates have left-wing presidents.
July 9, 2025 at 1:01 PM
March 17, 2025 at 1:12 PM
February 19, 2025 at 4:36 PM
Are you guys getting toilet paper?
February 11, 2025 at 8:05 PM
January 31, 2025 at 6:49 PM
January 13, 2025 at 10:14 PM
December 20, 2024 at 3:40 PM
December 20, 2024 at 3:37 PM
20 libros que te hayan influenciado y/o que no puedas olvidar.
Un libro al día, por veinte días, el orden no importa.
Sin explicaciones, ni reseñas, solo la tapa.

Día 6
December 4, 2024 at 12:17 AM
20 libros que te hayan influenciado y/o que no puedas olvidar.
Un libro al día, por veinte días, el orden no importa.
Sin explicaciones, ni reseñas, solo la tapa.

Día 5
December 2, 2024 at 1:46 PM
20 libros que te hayan influenciado y/o que no puedas olvidar.
Un libro al día, por veinte días, el orden no importa.
Sin explicaciones, ni reseñas, solo la tapa.

Día 4
December 1, 2024 at 8:53 PM
20 libros que te hayan influenciado y/o que no puedas olvidar.
Un libro al día, por veinte días, el orden no importa.
Sin explicaciones, ni reseñas, solo la tapa.

Día 3.
November 30, 2024 at 7:00 PM
20 libros que te hayan influenciado y/o que no puedas olvidar.
Un libro al día, por veinte días, el orden no importa.
Sin explicaciones, ni reseñas, solo la tapa.

Día 2.
November 29, 2024 at 2:08 PM
20 libros que te hayan influenciado y/o que no puedas olvidar.
Un libro al día, por veinte días, el orden no importa.
Sin explicaciones, ni reseñas, solo la tapa.*

*Lo difícil será acordarse de hacerlo

Día 1.
November 28, 2024 at 9:05 PM