Our results indicate that distributing selective pressures across the population minimizes the emergence of drug resistance in gonorrhea in US MSM and underscore the importance of disease and context-specific decision-making. [10/10]

It was possible to find combinations of parameters where equal allocation was worse than sequential, but these were rare edge cases that required a combination of unlikely events. Even then, the difference between strategies was not large [9/10]

Equal allocation was still better when we changed the prevalence threshold from 5% to 1% or 10%, and across a wide range of parameter values for parameters that determine underlying model behavior [8/10]

The sequential strategy had met the 5% resistance prevalence threshold i) for each drug individually and ii) for all 3 drugs in at least as many simulations and iii) for at least as many drugs on average compared to the equal allocation strategy [7/10]

Our results indicate that distributing selective pressures across the population minimizes the emergence of drug resistance in gonorrhea in US MSM and underscore the importance of disease and context-specific decision-making. [10/10]

It was possible to find combinations of parameters where equal allocation was worse than sequential, but these were rare edge cases that required a combination of unlikely events. Even then, the difference between strategies was not large [9/10]

Today Natalie Baker presented our work towards clean energy solutions in the Longwood Medical Area at the Thriving Together conference at BU and received this award! So proud of this team! @bumedicine.bsky.social @harvardcchange.bsky.social
@harvardmed.bsky.social
@hsph.harvard.edu