After a summer break, @mcbi-amsumc.bsky.social #SingleCellClub is back! Looking forward to Fern Bosada-Musselwhite's talk on quantifying heart extracellular matrix using (light sheet) microscopy 🔬 tomorrow!

Altogether, this model highlights the potential of lymphoma-on-chip models to study the role of lymph node stromal cells in cancer development and progression. Stay tuned for updates on this project!

(2) They also potentiated the ability of lymphoma cells to enhance lymphatic vessel permeability, although they did not affect permeability on their own.

In addition, to survival this model hint at a role of FRCs in contributing to lymphoma cell metastasis in two different ways. (1) They promoted directional migration of lymphoma cells towards the lymphatic vessels.

The addition of primary FRCs in the model improved the viability of the lymphoma cells, which was linked to increased production of interleukin-6, a known survival factor for hematological cancer cells.

They describe the construction of a lymphatic vessel (red) surrounded by lymphoma cells (DLBCL, blue) and primary fibroblastic reticular cells (FRCs, green) in a hydrogel.

Hi! Could you add us to the starter pack too, please? :)

Hello Lucille! Could you add us to this starter pack, please?

Hi Jon, could you add us if still possible? :)

Hi! We’re late to the party but could you add us?