Cameron McAlpine
@mcalpinelab.bsky.social
Heart-brain circuits in sleep, cardiovascular, and neurological disorders
Associate Professor at the Icahn School of Medicine at Mount Sinai
New York City
https://labs.icahn.mssm.edu/mcalpinelab/
Associate Professor at the Icahn School of Medicine at Mount Sinai
New York City
https://labs.icahn.mssm.edu/mcalpinelab/
Reposted by Cameron McAlpine
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 4, 2025 at 4:32 PM
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Reposted by Cameron McAlpine
New @science.org
A peptide released from white blood cells, directed against bacteria, can also poke holes in the membrane of heart muscle cells and induce a lethal arrhythmia (ventricular tachycardia). In the mouse model.
www.science.org/doi/10.1126/...
A peptide released from white blood cells, directed against bacteria, can also poke holes in the membrane of heart muscle cells and induce a lethal arrhythmia (ventricular tachycardia). In the mouse model.
www.science.org/doi/10.1126/...
Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia
Ventricular tachycardia disrupts the heart’s coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrh...
www.science.org
September 4, 2025 at 6:03 PM
New @science.org
A peptide released from white blood cells, directed against bacteria, can also poke holes in the membrane of heart muscle cells and induce a lethal arrhythmia (ventricular tachycardia). In the mouse model.
www.science.org/doi/10.1126/...
A peptide released from white blood cells, directed against bacteria, can also poke holes in the membrane of heart muscle cells and induce a lethal arrhythmia (ventricular tachycardia). In the mouse model.
www.science.org/doi/10.1126/...
It was a pleasure to present data from the lab at #ESCcongress! There has been a great focus on neuronal and immune contributions to CVD.
August 31, 2025 at 11:06 AM
It was a pleasure to present data from the lab at #ESCcongress! There has been a great focus on neuronal and immune contributions to CVD.
I am honored to receive this award! It is a testament to the lab and their hard work!
✨CONGRATULATIONS @mcalpinelab.bsky.social on being honored w/ the Dr. Harold & Golden Lamport Basic Research Award for demonstrating exceptional promise for making significant, long-term contributions to biomedical research!🎉
@mountsinainyc.bsky.social @sinaiimmuno.bsky.social
@mountsinainyc.bsky.social @sinaiimmuno.bsky.social
August 12, 2025 at 7:17 PM
I am honored to receive this award! It is a testament to the lab and their hard work!
Reposted by Cameron McAlpine
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
July 16, 2025 at 5:37 PM
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Reposted by Cameron McAlpine
What happens in Vagus🎰... find out on July 29th at 10am when you join host Dr. Sarah Stanley as she welcomes University of Virginia's Dr. John Campbell @augcsoup.bsky.social to the #BrainBodyResearchInstitute Seminar Series @mountsinainyc.bsky.social. Register👉 mountsinai.zoom.us/webinar/regi...
July 8, 2025 at 8:40 PM
What happens in Vagus🎰... find out on July 29th at 10am when you join host Dr. Sarah Stanley as she welcomes University of Virginia's Dr. John Campbell @augcsoup.bsky.social to the #BrainBodyResearchInstitute Seminar Series @mountsinainyc.bsky.social. Register👉 mountsinai.zoom.us/webinar/regi...
Very much looking forward to having Tim as a colleague and lab neighbor! Many exciting collaborations to come!
Thrilled to announce that I will be joining the @mountsinaicvri.bsky.social at the Icahn School of Medicine at Mount Sinai as an Assistant Professor in January! My laboratory will focus on nutrient transport and cellular metabolism in physiology and disease.
July 3, 2025 at 4:05 PM
Very much looking forward to having Tim as a colleague and lab neighbor! Many exciting collaborations to come!
Reposted by Cameron McAlpine
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology
McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.
www.nature.com
June 24, 2025 at 1:24 PM
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Cameron McAlpine
We are proud to announce that five CVRI faculty members - Fil Swirski (@filswirski.bsky.social), Mandy van Leent, Cameron McAlpine (@mcalpinelab.bsky.social), Maria Noval, and Sikander Hayat - will be presenting their groundbreaking work at Atherosclerosis GRC this Friday, June 27th.
2025 Atherosclerosis Conference GRC
The 2025 Gordon Research Conference on Atherosclerosis will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
June 23, 2025 at 1:20 PM
We are proud to announce that five CVRI faculty members - Fil Swirski (@filswirski.bsky.social), Mandy van Leent, Cameron McAlpine (@mcalpinelab.bsky.social), Maria Noval, and Sikander Hayat - will be presenting their groundbreaking work at Atherosclerosis GRC this Friday, June 27th.
Check out our review on neural mechanisms in cardiovascular health and disease! 👇
Happy to share a new review:
Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research www.ahajournals.org/doi/full/10....
Part of a series on Inter-organ communication!
Great teamwork: KA Ziegler, S Engelhardt, D Carnevale, C McAlpine, T Guzik, S Dimmeler!
Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research www.ahajournals.org/doi/full/10....
Part of a series on Inter-organ communication!
Great teamwork: KA Ziegler, S Engelhardt, D Carnevale, C McAlpine, T Guzik, S Dimmeler!
Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research
Although the neurocardiac axis is central to cardiovascular homeostasis, its dysregulation
drives heart failure and cardiometabolic diseases. This review examines the bidirectional
interplay between t...
www.ahajournals.org
May 22, 2025 at 7:01 PM
Check out our review on neural mechanisms in cardiovascular health and disease! 👇
A wonderful perspective that includes the idea of cardiovascular disease as a stressor that induces sleep.
Experimental evidence that post-stress sleep has the capacity to build resilience
cell.com/neuron/fullt...
cell.com/neuron/fullt...
Sleep and the recovery from stress
Stress often causes insomnia, yet certain stressors, including illness and psychosocial
events, can induce sleep. Yu et al. propose that post-stress sleep contributes to
resilience and discuss potenti...
cell.com
May 22, 2025 at 4:09 PM
A wonderful perspective that includes the idea of cardiovascular disease as a stressor that induces sleep.
We are looking for a scientist to join the growing Brain-Body Research Institute at Mount Sinai! Consider joining a dynamic fundamental and translational team investigating inter-organ physiology and communication between the brain and periphery. Feel free to reach out if you have any questions.
The Brain-Body Research Institute @IcahnMountSinai is hiring an Associate Director to build clinical and translational research in brain-body sciences. See ad here: neuroscience.mssm.edu/pdf/Brain-Bo.... @sinaibrain.bsky.social @sinaiimmuno.bsky.social @brainbodylab.bsky.social
May 19, 2025 at 2:50 PM
We are looking for a scientist to join the growing Brain-Body Research Institute at Mount Sinai! Consider joining a dynamic fundamental and translational team investigating inter-organ physiology and communication between the brain and periphery. Feel free to reach out if you have any questions.
Reposted by Cameron McAlpine
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
May 15, 2025 at 6:05 PM
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
Reposted by Cameron McAlpine
Exciting news! 🎉
Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.
Please join us in welcoming him to this important role 👏👏 👏
📎: www.jacc.org/announcement...
Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.
Please join us in welcoming him to this important role 👏👏 👏
📎: www.jacc.org/announcement...
May 5, 2025 at 6:48 PM
Exciting news! 🎉
Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.
Please join us in welcoming him to this important role 👏👏 👏
📎: www.jacc.org/announcement...
Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.
Please join us in welcoming him to this important role 👏👏 👏
📎: www.jacc.org/announcement...
Reposted by Cameron McAlpine
Very excited to share part of my postdoctoral work from the @tjryan.bsky.social lab, out now in @nature.com. Here, my brilliant co-author @andreamunozz.bsky.social and I explored the link between memory engrams and whole-body metabolism.
A thread: 🧵
www.nature.com/articles/s41...
A thread: 🧵
www.nature.com/articles/s41...
Cold memories control whole-body thermoregulatory responses - Nature
Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...
www.nature.com
April 24, 2025 at 2:26 PM
Very excited to share part of my postdoctoral work from the @tjryan.bsky.social lab, out now in @nature.com. Here, my brilliant co-author @andreamunozz.bsky.social and I explored the link between memory engrams and whole-body metabolism.
A thread: 🧵
www.nature.com/articles/s41...
A thread: 🧵
www.nature.com/articles/s41...
We are thrilled to share the latest from the lab! We demonstrate that multi-organ MCSF-dependent myelopoiesis is dynamic in MS and is manipulated by lifestyle to influence disease severity and neuroinflammation. Big congrats to the whole team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis - Nature Communications
Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clini...
www.nature.com
April 17, 2025 at 7:35 PM
We are thrilled to share the latest from the lab! We demonstrate that multi-organ MCSF-dependent myelopoiesis is dynamic in MS and is manipulated by lifestyle to influence disease severity and neuroinflammation. Big congrats to the whole team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Cameron McAlpine
Excited to announce an official scientific statement from the @americanheart.bsky.social!
"Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health"
Special thanks to @m-pst-ongephd.bsky.social
www.ahajournals.org/doi/10.1161/...
"Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health"
Special thanks to @m-pst-ongephd.bsky.social
www.ahajournals.org/doi/10.1161/...
April 15, 2025 at 4:01 PM
Excited to announce an official scientific statement from the @americanheart.bsky.social!
"Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health"
Special thanks to @m-pst-ongephd.bsky.social
www.ahajournals.org/doi/10.1161/...
"Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health"
Special thanks to @m-pst-ongephd.bsky.social
www.ahajournals.org/doi/10.1161/...
Reposted by Cameron McAlpine
A Huge Congratulations to @scottrussophd.bsky.social 👉 named Director of the NEW #BrainBody Research Institute. The Institute will focus on holistic approaches to science & medicine to gain a better understanding of how the brain & body interact in health & disease. Again, Congratulations Scott!👏💯
March 24, 2025 at 12:59 PM
A Huge Congratulations to @scottrussophd.bsky.social 👉 named Director of the NEW #BrainBody Research Institute. The Institute will focus on holistic approaches to science & medicine to gain a better understanding of how the brain & body interact in health & disease. Again, Congratulations Scott!👏💯
Reposted by Cameron McAlpine
📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis
Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.
www.science.org
March 21, 2025 at 6:14 PM
📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Reposted by Cameron McAlpine
Sleep duration/timing and glucose regulation in over 1100 people with 14-day continuous glucose sensor
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Sleep and Long-Term Risk of Type 2 Diabetes in Women With Gestational Diabetes
This cohort study assesses whether sleep duration and quality are associated with incidence of type 2 diabetes among women with a history of gestational diabetes who participated in the Nurses’ Health...
jamanetwork.com
March 5, 2025 at 4:44 PM
Sleep duration/timing and glucose regulation in over 1100 people with 14-day continuous glucose sensor
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Cameron McAlpine
Better sleep quality could reduce inflammation and improve health outcomes in obesity
doi.org/10.1093/jimm...
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@jimmunol.bsky.social
Impact of sleep deprivation on monocyte subclasses and function
Abstract. The relationship between sleep deprivation, obesity, and systemic inflammation is a critical area of investigation due to its significant impact
doi.org
February 26, 2025 at 8:49 PM
Better sleep quality could reduce inflammation and improve health outcomes in obesity
doi.org/10.1093/jimm...
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@jimmunol.bsky.social
Reposted by Cameron McAlpine
1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social
Read it here: www.nature.com/articles/s41...
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social
Read it here: www.nature.com/articles/s41...
A crucial role for the cortical amygdala in shaping social encounters - Nature
The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.
www.nature.com
February 12, 2025 at 5:12 PM
1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social
Read it here: www.nature.com/articles/s41...
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social
Read it here: www.nature.com/articles/s41...
Check out this beautiful image called "Sleepy Aorta" from Jake, a student in the lab! This is an immunofluorescent image of atherosclerosis in the aortic root of a mouse with poor sleep. Give the post a ❤️ to vote for the #ArtoftheBrain contest! ❤️↔️🧠
How important is it to get enough sleep? In the McAlpine Lab's Walter Jacob's image "Sleepy Aorta", immunofluorescence staining captures the immense cardiovascular inflammation following months of poor sleep. @mcalpinelab.bsky.social VOTE NOW for #ArtoftheBrain Image #3 👉 Most 💚's wins!
December 17, 2024 at 7:54 PM
Check out this beautiful image called "Sleepy Aorta" from Jake, a student in the lab! This is an immunofluorescent image of atherosclerosis in the aortic root of a mouse with poor sleep. Give the post a ❤️ to vote for the #ArtoftheBrain contest! ❤️↔️🧠
Reposted by Cameron McAlpine
In medical school in the 1980s, we were taught that depression was an unpleasant and unwanted side effect of having a heart attack. But what if it is a healthy physiological response to help you heal by lowering demand on your heart? www.nature.com/articles/s41... | @natureportfolio.bsky.social
Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature
Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...
www.nature.com
November 19, 2024 at 2:28 PM
In medical school in the 1980s, we were taught that depression was an unpleasant and unwanted side effect of having a heart attack. But what if it is a healthy physiological response to help you heal by lowering demand on your heart? www.nature.com/articles/s41... | @natureportfolio.bsky.social