Microstructure & Connectivity Lab
@mc-lab.bsky.social
M&C Lab @ Vanderbilt University Medical Center
(PI: Kurt Schilling)
https://microstructure-connectivity-lab.com/
(PI: Kurt Schilling)
https://microstructure-connectivity-lab.com/
(4/4) "These findings suggest that ALPS-derived metrics may not provide a direct measure of glymphatic function but rather reflect underlying axonal geometry. Interpretations of ALPS-derived metrics as biomarkers of glymphatic function must consider these anatomical complexities"
July 27, 2025 at 1:06 PM
(4/4) "These findings suggest that ALPS-derived metrics may not provide a direct measure of glymphatic function but rather reflect underlying axonal geometry. Interpretations of ALPS-derived metrics as biomarkers of glymphatic function must consider these anatomical complexities"
(3/4) and this study by Georgiopoulos & team (academic.oup.com/braincomms/a...) showing biases due to crossing fibers. We extend this to undulations/dispersion.
Diffusion tensor imaging along the perivascular space: the bias from crossing fibres
Georgiopoulos et al. report that crossing fibres significantly affect diffusion tensor imaging along the perivascular space, raising concerns about its rel
academic.oup.com
July 27, 2025 at 1:06 PM
(3/4) and this study by Georgiopoulos & team (academic.oup.com/braincomms/a...) showing biases due to crossing fibers. We extend this to undulations/dispersion.
(2/4) motivated by this beautiful study by Adam Wright (onlinelibrary.wiley.com/doi/10.1002/...) where they show that radial asymmetry (what DTI-ALPS measures) exists throughout all WM, regardless of vascular orientation. We confirm this and show it exists at high b-values.
Exploring Radial Asymmetry in MR Diffusion Tensor Imaging and Its Impact on the Interpretation of Glymphatic Mechanisms
Background Diffusion imaging holds great potential for the non-invasive assessment of the glymphatic system in humans. One technique, diffusion tensor imaging along the perivascular space (DTI-ALPS)...
onlinelibrary.wiley.com
July 27, 2025 at 1:06 PM
(2/4) motivated by this beautiful study by Adam Wright (onlinelibrary.wiley.com/doi/10.1002/...) where they show that radial asymmetry (what DTI-ALPS measures) exists throughout all WM, regardless of vascular orientation. We confirm this and show it exists at high b-values.
(3/3) come see Michael Kim discuss this @ismrm.bsky.social session "White Matter: Aging & Diseases" Monday at 8:15!
May 11, 2025 at 8:49 PM
(3/3) come see Michael Kim discuss this @ismrm.bsky.social session "White Matter: Aging & Diseases" Monday at 8:15!
(2/3) we show these can be used to (A) define normative trajectories across pathways (B) identify developmental milestones (C) detect deviation from normal (examples in AD, MCI, epilepsy, Autism, ADHD, Depression, Anxiety) (D) provide centile scores for new out of sample datasets
May 11, 2025 at 8:49 PM
(2/3) we show these can be used to (A) define normative trajectories across pathways (B) identify developmental milestones (C) detect deviation from normal (examples in AD, MCI, epilepsy, Autism, ADHD, Depression, Anxiety) (D) provide centile scores for new out of sample datasets
Bonus pretty pictures of rats, monkeys, racooons...all using lessons, guidelines, and recommendations from the papers above!
May 7, 2025 at 5:55 PM
Bonus pretty pictures of rats, monkeys, racooons...all using lessons, guidelines, and recommendations from the papers above!
Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3—Ex vivo imaging: Data processing, comparisons with microscopy, and tractography
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3—Ex vivo imaging: Data processing, comparisons with microscopy, and tractography
Preclinical diffusion MRI (dMRI) has proven value in methods development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. While dMRI enables in viv...
onlinelibrary.wiley.com
May 7, 2025 at 5:55 PM
Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3—Ex vivo imaging: Data processing, comparisons with microscopy, and tractography
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2—Ex vivo imaging: Added value and acquisition
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2—Ex vivo imaging: Added value and acquisition
The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non-invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructur...
onlinelibrary.wiley.com
May 7, 2025 at 5:55 PM
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2—Ex vivo imaging: Added value and acquisition
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small‐animal imaging
Small-animal diffusion MRI (dMRI) has been used for methodological development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. The steps from anim...
onlinelibrary.wiley.com
May 7, 2025 at 5:55 PM
Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...