(1/4) Our recent work shows DTI-ALPS is confounded by white matter geometry (crossing fibers, undulation, dispersion), ALPS-asymmetry signature (ALPS measures asymmetry of diffusion) occurs throughout all WM, and ALPS-WM is not always orthogonal to PVS onlinelibrary.wiley.com/share/TPCABU...

"Perhaps this is why it is called research rather than search" ... one of my favorite quotes (can be applied to all research) ... from Novikov's "On Modeling" pubmed.ncbi.nlm.nih.gov/29493816/

Join the @ismrm.bsky.social Diffusion study group virtual meeting on June 30th for "Time-Dependent Diffusion: Microseconds, Seconds, Months". Register by finding the virtual meeting here: www.ismrm.org/virtual-meet...

Our newest manuscript now in Scientific Reports. Title says it all "The relationship of white matter tract orientation to vascular geometry in the human brain" - where does WM align (and not align) with vasculature? @masi-lab.bsky.social www.nature.com/articles/s41...

(2/3) we show these can be used to (A) define normative trajectories across pathways (B) identify developmental milestones (C) detect deviation from normal (examples in AD, MCI, epilepsy, Autism, ADHD, Depression, Anxiety) (D) provide centile scores for new out of sample datasets

Bonus pretty pictures of rats, monkeys, racooons...all using lessons, guidelines, and recommendations from the papers above!