Weili Ma
maweili.bsky.social
Weili Ma
@maweili.bsky.social
Brain cancer researcher in the Philadelphia area
Reposted by Weili Ma
This week in #Science #Immunology: Lukas Amann, Marco Prinz, & colleagues at @uni-freiburg.de report that #extrasinusoidal #macrophages in the #mouse #DuraMater represent a distinct subset of #CNS -associated macrophages whose role is shaped by #autoimmune #neuroinflammation! #neuroimmunology
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.
www.science.org
December 20, 2024 at 9:48 PM
Reposted by Weili Ma
Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....

👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
Lipids: Emerging Players of Microglial Biology
Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...
onlinelibrary.wiley.com
December 17, 2024 at 2:46 PM
Reposted by Weili Ma
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.

www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Reposted by Weili Ma
Many thanks to The Scientist for covering our recent paper on fibrotic scarring and brain tumor recurrence 🙏

Here's the #openaccess link for our original paper in Cancer Cell led by Watson*, Zomer* et al:
www.cell.com/cancer-cell/...

#scicomm 🧪🔬

www.the-scientist.com/blocking-sca...
Blocking Scar Formation Prevents Glioblastoma Recurrence
A combination of three therapies prevented scar tissue and stopped glioblastoma in its tracks in mice.
www.the-scientist.com
November 20, 2024 at 1:14 PM