Matthew Sydes
@mattsydes.bsky.social
linktr.ee/mattsydes
Head of Data-Driven Clinical Trials at NHS England.
Hon Prof of Clinical Trials & Methodology at UCL.
Hon Fellow at HDRUK.
Always keen to talk clinical trials & evidence-based healthcare.
Tied to kettle & news.
Local trips by bike.
Head of Data-Driven Clinical Trials at NHS England.
Hon Prof of Clinical Trials & Methodology at UCL.
Hon Fellow at HDRUK.
Always keen to talk clinical trials & evidence-based healthcare.
Tied to kettle & news.
Local trips by bike.
Pinned
Matthew Sydes
@mattsydes.bsky.social
· May 20
https://digital.nhs.uk/blog/data-poin…
My most recent blog post for NHSE on clinical trials is here: digital.nhs.uk/blog/data-poin…
It's my contribution fo#ClinicalTrialsDayay.
It's a personal story.
My take-away message for you is: "Every person that ... joins any trial is a hero."
It's my contribution fo#ClinicalTrialsDayay.
It's a personal story.
My take-away message for you is: "Every person that ... joins any trial is a hero."
Reposted by Matthew Sydes
Founders Lecture #SCT2025 on DMCs - Thomas Fleming flags the @nihr.bsky.social funded DAMOCLES study that developed a charter for DMCs to support them to do their jobs well. Full paper here www.thelancet.com/journals/lan...
A proposed charter for clinical trial data monitoring committees: helping them to do their job well
Formal monitoring of data from randomised controlled trials (RCTs) is becoming more
common. Wide variation exists in the structure and organisation of data monitoring
committees (DMCs), with little gu...
www.thelancet.com
May 20, 2025 at 3:52 PM
Founders Lecture #SCT2025 on DMCs - Thomas Fleming flags the @nihr.bsky.social funded DAMOCLES study that developed a charter for DMCs to support them to do their jobs well. Full paper here www.thelancet.com/journals/lan...
Reposted by Matthew Sydes
Hard to believe it is now 20 years (!) since we published the DAMOCLES Charter to support data monitoring committees do their job well. It is still routinely used to inform all NIHR DMCs today 😊
@mattsydes.bsky.social
@mattsydes.bsky.social
Founders Lecture #SCT2025 on DMCs - Thomas Fleming flags the @nihr.bsky.social funded DAMOCLES study that developed a charter for DMCs to support them to do their jobs well. Full paper here www.thelancet.com/journals/lan...
A proposed charter for clinical trial data monitoring committees: helping them to do their job well
Formal monitoring of data from randomised controlled trials (RCTs) is becoming more
common. Wide variation exists in the structure and organisation of data monitoring
committees (DMCs), with little gu...
www.thelancet.com
May 20, 2025 at 5:55 PM
Hard to believe it is now 20 years (!) since we published the DAMOCLES Charter to support data monitoring committees do their job well. It is still routinely used to inform all NIHR DMCs today 😊
@mattsydes.bsky.social
@mattsydes.bsky.social
My most recent blog post for NHSE on clinical trials is here: digital.nhs.uk/blog/data-poin…
It's my contribution fo#ClinicalTrialsDayay.
It's a personal story.
My take-away message for you is: "Every person that ... joins any trial is a hero."
It's my contribution fo#ClinicalTrialsDayay.
It's a personal story.
My take-away message for you is: "Every person that ... joins any trial is a hero."
https://digital.nhs.uk/blog/data-poin…
May 20, 2025 at 3:59 PM
My most recent blog post for NHSE on clinical trials is here: digital.nhs.uk/blog/data-poin…
It's my contribution fo#ClinicalTrialsDayay.
It's a personal story.
My take-away message for you is: "Every person that ... joins any trial is a hero."
It's my contribution fo#ClinicalTrialsDayay.
It's a personal story.
My take-away message for you is: "Every person that ... joins any trial is a hero."
It is my 30th anniversary of working in #ClinicalTrials today! I don't think I feel old enough to have hit this milestone, yet started at MRC Cancer Trials Office on 03-Apr-1995.
How to celebrate? Talking about better clinical trials, of course! Here's how...
1/5
How to celebrate? Talking about better clinical trials, of course! Here's how...
1/5
April 3, 2025 at 7:13 PM
It is my 30th anniversary of working in #ClinicalTrials today! I don't think I feel old enough to have hit this milestone, yet started at MRC Cancer Trials Office on 03-Apr-1995.
How to celebrate? Talking about better clinical trials, of course! Here's how...
1/5
How to celebrate? Talking about better clinical trials, of course! Here's how...
1/5
Did you see the EOI has opened a new tranche of trials to recruit with NHS DigiTrials?
You'll know someone with a trial that should explore this.
Apply now: lnkd.in/eiczmNpD
#NHSDigiTrials #ClinicalResearch #Healthcare #Innovation
You'll know someone with a trial that should explore this.
Apply now: lnkd.in/eiczmNpD
#NHSDigiTrials #ClinicalResearch #Healthcare #Innovation
March 12, 2025 at 8:18 PM
Did you see the EOI has opened a new tranche of trials to recruit with NHS DigiTrials?
You'll know someone with a trial that should explore this.
Apply now: lnkd.in/eiczmNpD
#NHSDigiTrials #ClinicalResearch #Healthcare #Innovation
You'll know someone with a trial that should explore this.
Apply now: lnkd.in/eiczmNpD
#NHSDigiTrials #ClinicalResearch #Healthcare #Innovation
Reposted by Matthew Sydes
Latest from #STAMPEDE - intensified AR targeting drives increased prevalence of AR mutations at progression compared to monotherapy patient samples jamanetwork.com/journals/jam...
Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer
This randomized clinical trial explores whether hormone intensification at start of androgen deprivation therapy alters selection of androgen receptor (AR) gene alterations within the gene body and/or...
jamanetwork.com
March 4, 2025 at 10:00 AM
Latest from #STAMPEDE - intensified AR targeting drives increased prevalence of AR mutations at progression compared to monotherapy patient samples jamanetwork.com/journals/jam...
Reposted by Matthew Sydes
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
January 17, 2025 at 1:58 PM
Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub.
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
To get it:
. net from raw.githubusercontent.com/tpmorris/kmu...
User feedback welcome!
1/
3 things that are on my mind:
▶️1 = HDR UK Honorary Fellows
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️2 = Sudlow Review
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️3 = Enhanced Health Data Research Gateway
www.linkedin.com/posts/nhs-tr... or x.com/NHSDigital/s...
▶️1 = HDR UK Honorary Fellows
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️2 = Sudlow Review
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️3 = Enhanced Health Data Research Gateway
www.linkedin.com/posts/nhs-tr... or x.com/NHSDigital/s...
November 5, 2024 at 7:08 PM
3 things that are on my mind:
▶️1 = HDR UK Honorary Fellows
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️2 = Sudlow Review
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️3 = Enhanced Health Data Research Gateway
www.linkedin.com/posts/nhs-tr... or x.com/NHSDigital/s...
▶️1 = HDR UK Honorary Fellows
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️2 = Sudlow Review
www.linkedin.com/posts/hdruk_... or x.com/HDR_UK/statu...
▶️3 = Enhanced Health Data Research Gateway
www.linkedin.com/posts/nhs-tr... or x.com/NHSDigital/s...
If you are missing (or sad about having missed) #ICTMC2024 from last week or #HDUG from this week, now's a good time to grab a cup of tea & read my first blog since joining NHS England Transformation Directorate's Data for R&D Programme. Here's a handy link: digital.nhs.uk/blog/data-po...
October 10, 2024 at 4:54 PM
If you are missing (or sad about having missed) #ICTMC2024 from last week or #HDUG from this week, now's a good time to grab a cup of tea & read my first blog since joining NHS England Transformation Directorate's Data for R&D Programme. Here's a handy link: digital.nhs.uk/blog/data-po...
***JOB ALERT***
I'm sure many of my #clinicaltrials colleagues in #industry and #academia will be interested in this advert for the Head of Data Operations for #DigiTrials at NHS England.
Link at beta.jobs.nhs.uk/candidate/jo...
Tight deadline (Sunday 06oct2024) just after #ICTMC2024.
I'm sure many of my #clinicaltrials colleagues in #industry and #academia will be interested in this advert for the Head of Data Operations for #DigiTrials at NHS England.
Link at beta.jobs.nhs.uk/candidate/jo...
Tight deadline (Sunday 06oct2024) just after #ICTMC2024.
September 26, 2024 at 8:02 AM
***JOB ALERT***
I'm sure many of my #clinicaltrials colleagues in #industry and #academia will be interested in this advert for the Head of Data Operations for #DigiTrials at NHS England.
Link at beta.jobs.nhs.uk/candidate/jo...
Tight deadline (Sunday 06oct2024) just after #ICTMC2024.
I'm sure many of my #clinicaltrials colleagues in #industry and #academia will be interested in this advert for the Head of Data Operations for #DigiTrials at NHS England.
Link at beta.jobs.nhs.uk/candidate/jo...
Tight deadline (Sunday 06oct2024) just after #ICTMC2024.