Matt Perich
@mattperich.bsky.social
Neuroscience, engineering, AI, music. Asst. Professor / PI at University of Montréal and Mila.
Pinned
Matt Perich
@mattperich.bsky.social
· Oct 7
Check out our new paper led by @oliviercodol.bsky.social ! We use RNNs to explore possible learning rules that lead to the dynamics we see in brains during behavior.
www.biorxiv.org/content/10.1...
#neuroskyence #compneurosky #neuroai
www.biorxiv.org/content/10.1...
#neuroskyence #compneurosky #neuroai
Reposted by Matt Perich
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
euraxess.ec.europa.eu
November 4, 2025 at 5:11 PM
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
If you're interested in dynamical systems analysis for neuroscience, definitely check out @oliviercodol.bsky.social 's revised version of our RL paper! Very cool results in the new Fig 6, worth it regardless of if you saw our previous version or if it's all new.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 6, 2025 at 5:58 PM
If you're interested in dynamical systems analysis for neuroscience, definitely check out @oliviercodol.bsky.social 's revised version of our RL paper! Very cool results in the new Fig 6, worth it regardless of if you saw our previous version or if it's all new.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A big "get" for the Champalimaud! Excited to see what comes out of the Warehouse and the next phase of Juan's lab
🚨Big news!🚨
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
The lab is relocating to Lisbon, joining a great team of experimental and theoretical neuroscientists, and the Neurotechnology Warehouse, a new initiative to bridge basic and translational research.
I'll be sharing postdoc openings soon. Come join us in this new incarnation of the lab!
🧠🎼 What does it take to restore movement? Neuroscientist and engineer, @juangallego.bsky.social, joins the new Centre for Restorative Neurotechnology at the Champalimaud Foundation.
🔗 Find out more in this interview: www.fchampalimaud.org/news/juan-al...
🔗 Find out more in this interview: www.fchampalimaud.org/news/juan-al...
October 7, 2025 at 7:12 PM
A big "get" for the Champalimaud! Excited to see what comes out of the Warehouse and the next phase of Juan's lab
Reposted by Matt Perich
Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice!
www.biorxiv.org/content/10.1...
#neuroskyence #compneurosky 🧪
1/12
www.biorxiv.org/content/10.1...
#neuroskyence #compneurosky 🧪
1/12
September 25, 2025 at 4:45 PM
Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice!
www.biorxiv.org/content/10.1...
#neuroskyence #compneurosky 🧪
1/12
www.biorxiv.org/content/10.1...
#neuroskyence #compneurosky 🧪
1/12
Reposted by Matt Perich
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org
September 8, 2025 at 4:34 PM
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🚨 I’m excited to say that my CIHR Project Grant was funded! My NHP lab is now full-speed-ahead, and I’m hiring experimentalists (postdoc, PhD student, and/or a tech/manager). We’ll do multi-region ephys during reaching/grasping in macaques, with behavioral and spinal perturbations.
August 13, 2025 at 4:23 PM
🚨 I’m excited to say that my CIHR Project Grant was funded! My NHP lab is now full-speed-ahead, and I’m hiring experimentalists (postdoc, PhD student, and/or a tech/manager). We’ll do multi-region ephys during reaching/grasping in macaques, with behavioral and spinal perturbations.
Awesome work from @juangallego.bsky.social and lab. An interface from single motoneuron control in tetraplegia!
🚨 New preprint + thread 🧵
We've gone back to studying motoneuron control principles and their applications & here's paper #1:
A proof-of-concept study showing that people with tetraplegic spinal cord injury can control up to 2DoF from a single intramuscular implant
www.medrxiv.org/content/10.1...
We've gone back to studying motoneuron control principles and their applications & here's paper #1:
A proof-of-concept study showing that people with tetraplegic spinal cord injury can control up to 2DoF from a single intramuscular implant
www.medrxiv.org/content/10.1...
August 7, 2025 at 7:07 PM
Awesome work from @juangallego.bsky.social and lab. An interface from single motoneuron control in tetraplegia!
Reposted by Matt Perich
Check out @jordancollver.bsky.social’s great illustration of modular RNNs training to work like a bio-brain🦾🧠
Thanks to Crearte for featuring our collaboration!
www.instagram.com/crearte.ca/p...
Thanks to Crearte for featuring our collaboration!
www.instagram.com/crearte.ca/p...
The Crearte Foundation | #ArtScience on Instagram: "When a neurobiologist is also a comic artist, science can have a whole new storyline.
In a 2022 collaboration between the Rajan Lab at Harvard Med...
6 likes, 0 comments - crearte.ca on July 28, 2025: "When a neurobiologist is also a comic artist, science can have a whole new storyline.
In a 2022 collaboration between the Rajan Lab at Harvard Med...
www.instagram.com
August 6, 2025 at 7:04 PM
Check out @jordancollver.bsky.social’s great illustration of modular RNNs training to work like a bio-brain🦾🧠
Thanks to Crearte for featuring our collaboration!
www.instagram.com/crearte.ca/p...
Thanks to Crearte for featuring our collaboration!
www.instagram.com/crearte.ca/p...
Reposted by Matt Perich
Very happy about my former mentor Sara Solla having received the Valentin Braitenberg Award for her lifelong contributions to computational neuroscience!
Sara will be giving a lecture at the upcoming @bernsteinneuro.bsky.social meeting which you shouldn't miss.
bernstein-network.de/en/newsroom/...
Sara will be giving a lecture at the upcoming @bernsteinneuro.bsky.social meeting which you shouldn't miss.
bernstein-network.de/en/newsroom/...
Sara A. Solla receives the Valentin Braitenberg Award for Computational Neuroscience 2025 – Bernstein Network Computational Neuroscience
bernstein-network.de
August 6, 2025 at 2:25 PM
Very happy about my former mentor Sara Solla having received the Valentin Braitenberg Award for her lifelong contributions to computational neuroscience!
Sara will be giving a lecture at the upcoming @bernsteinneuro.bsky.social meeting which you shouldn't miss.
bernstein-network.de/en/newsroom/...
Sara will be giving a lecture at the upcoming @bernsteinneuro.bsky.social meeting which you shouldn't miss.
bernstein-network.de/en/newsroom/...
📰 I really enjoyed writing this article with @thetransmitter.bsky.social! In it, I summarize parts of our recent perspective article on neural manifolds (www.nature.com/articles/s41...), with a focus on highlighting just a few cool insights into the brain we've already seen at the population level.
Neural manifold properties can help us understand how animal brains deal with competing and multifaceted information, execute flexible behaviors and reuse common computations, writes @mattperich.bsky.social.
#neuroskyence
www.thetransmitter.org/neural-dynam...
#neuroskyence
www.thetransmitter.org/neural-dynam...
Neural population-based approaches have opened new windows into neural computations and behavior
Neural manifold properties can help us understand how animal brains deal with complex information, execute flexible behaviors and reuse common computations.
www.thetransmitter.org
August 4, 2025 at 6:45 PM
📰 I really enjoyed writing this article with @thetransmitter.bsky.social! In it, I summarize parts of our recent perspective article on neural manifolds (www.nature.com/articles/s41...), with a focus on highlighting just a few cool insights into the brain we've already seen at the population level.
Reposted by Matt Perich
🚨New paper🚨
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
August 1, 2025 at 9:57 AM
🚨New paper🚨
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.
Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
Reposted by Matt Perich
'manifolds', and the overall conception of the brain using a dynamical systems framework, have come a long way.
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
www.nature.com
July 30, 2025 at 5:36 AM
'manifolds', and the overall conception of the brain using a dynamical systems framework, have come a long way.
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
www.nature.com
July 29, 2025 at 7:06 PM
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW
Reposted by Matt Perich
Finally out!
Eight years after initiating this study with Simon Borgognon, Nicolo Macellari, and Gregoire Courtine, we have uncovered neural population dynamics shared among premotor, motor, and somatosensory cortices during various types of locomotor tasks.
www.nature.com/articles/s41...
Eight years after initiating this study with Simon Borgognon, Nicolo Macellari, and Gregoire Courtine, we have uncovered neural population dynamics shared among premotor, motor, and somatosensory cortices during various types of locomotor tasks.
www.nature.com/articles/s41...
Regional specialization of movement encoding across the primate sensorimotor cortex - Nature Communications
How the cortex generates movement to achieve different tasks remains poorly understood. Here the authors show that the cortex serializes motor control by first performing task-specific computations in...
www.nature.com
July 1, 2025 at 4:15 PM
Finally out!
Eight years after initiating this study with Simon Borgognon, Nicolo Macellari, and Gregoire Courtine, we have uncovered neural population dynamics shared among premotor, motor, and somatosensory cortices during various types of locomotor tasks.
www.nature.com/articles/s41...
Eight years after initiating this study with Simon Borgognon, Nicolo Macellari, and Gregoire Courtine, we have uncovered neural population dynamics shared among premotor, motor, and somatosensory cortices during various types of locomotor tasks.
www.nature.com/articles/s41...
Our new approach for scalable, generalizable, and efficient neural population decoding is now online! Here we focus on real-time BCI but I'm excited about all of our next steps building on this. Awesome work led by @averyryoo.bsky.social @nandahkrishna.bsky.social @ximengmao.bsky.social
New preprint! 🧠🤖
How do we build neural decoders that are:
⚡️ fast enough for real-time use
🎯 accurate across diverse tasks
🌍 generalizable to new sessions, subjects, and even species?
We present POSSM, a hybrid SSM architecture that optimizes for all three of these axes!
🧵1/7
How do we build neural decoders that are:
⚡️ fast enough for real-time use
🎯 accurate across diverse tasks
🌍 generalizable to new sessions, subjects, and even species?
We present POSSM, a hybrid SSM architecture that optimizes for all three of these axes!
🧵1/7
June 11, 2025 at 2:44 PM
Our new approach for scalable, generalizable, and efficient neural population decoding is now online! Here we focus on real-time BCI but I'm excited about all of our next steps building on this. Awesome work led by @averyryoo.bsky.social @nandahkrishna.bsky.social @ximengmao.bsky.social
Reposted by Matt Perich
Very late, but had a 🔥 time at my first Cosyne presenting my work with @nandahkrishna.bsky.social, Ximeng Mao, @mattperich.bsky.social, and @glajoie.bsky.social on real-time neural decoding with hybrid SSMs. Keep an eye out for a preprint (hopefully) soon 👀
#Cosyne2025 @cosynemeeting.bsky.social
#Cosyne2025 @cosynemeeting.bsky.social
April 4, 2025 at 5:21 AM
Very late, but had a 🔥 time at my first Cosyne presenting my work with @nandahkrishna.bsky.social, Ximeng Mao, @mattperich.bsky.social, and @glajoie.bsky.social on real-time neural decoding with hybrid SSMs. Keep an eye out for a preprint (hopefully) soon 👀
#Cosyne2025 @cosynemeeting.bsky.social
#Cosyne2025 @cosynemeeting.bsky.social
Reposted by Matt Perich
Many apparent disagreements over the utility of neural manifolds come from a lack of clarity on what the term really encompasses, argues @mattperich.bsky.social
#neuroskyence
www.thetransmitter.org/neural-dynam...
#neuroskyence
www.thetransmitter.org/neural-dynam...
Neural manifolds: Latest buzzword or pathway to understand the brain?
When you cut away the misconceptions, neural manifolds present a conceptually appropriate level at which systems neuroscientists can study the brain.
www.thetransmitter.org
March 30, 2025 at 3:02 PM
Many apparent disagreements over the utility of neural manifolds come from a lack of clarity on what the term really encompasses, argues @mattperich.bsky.social
#neuroskyence
www.thetransmitter.org/neural-dynam...
#neuroskyence
www.thetransmitter.org/neural-dynam...
Reposted by Matt Perich
🧠 Our new (NIH funded!) paper reveals how the brain creates internal dynamics during both real- and imagined navigation. We recorded directly from the human hippocampus as participants moved through physical space and when they mentally navigated imagined routes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour
Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...
www.nature.com
March 10, 2025 at 4:54 PM
🧠 Our new (NIH funded!) paper reveals how the brain creates internal dynamics during both real- and imagined navigation. We recorded directly from the human hippocampus as participants moved through physical space and when they mentally navigated imagined routes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Matt Perich
Want to hear more about how feedback can guide learning in RNNs for motor adaptation. Here is our new paper in Nat. Com. with Barbara Feulner and @juangallego.bsky.social www.nature.com/articles/s41...
A neural implementation model of feedback-based motor learning - Nature Communications
How the brain adapts our movements to new conditions remains unclear. Here, the authors show that a recurrent neural network that controls its output using error-based feedback can learn to count...
www.nature.com
February 21, 2025 at 4:51 PM
Want to hear more about how feedback can guide learning in RNNs for motor adaptation. Here is our new paper in Nat. Com. with Barbara Feulner and @juangallego.bsky.social www.nature.com/articles/s41...
Reposted by Matt Perich
Our paper from Junchol Park and collaborators that has been brewing for a while. Trying to capture our thinking about what action specification in striatum means and what would constitute evidence for such a model. Longer thread soon, but it’s online now. www.cell.com/neuron/fullt...
Conjoint specification of action by neocortex and striatum
Park et al. show that motor cortex and subcortical striatum act in concert to specify
the movement parameters of a reach-to-pull action in mice.
www.cell.com
January 24, 2025 at 1:34 AM
Our paper from Junchol Park and collaborators that has been brewing for a while. Trying to capture our thinking about what action specification in striatum means and what would constitute evidence for such a model. Longer thread soon, but it’s online now. www.cell.com/neuron/fullt...
Great initiative! The Transmitter is awesome.
I'm excited to share another project we've been working on: The Transmitter's first book, which includes some of our favorite essays from our first ~9 months. Download a copy here: www.thetransmitter.org/transmitter-...
December 18, 2024 at 6:49 PM
Great initiative! The Transmitter is awesome.
Reposted by Matt Perich
1/ Okay, one thing that has been revealed to me from the replies to this is that many people don't know (or refuse to recognize) the following fact:
The unts in ANN are actually not a terrible approximation of how real neurons work!
A tiny 🧵.
🧠📈 #NeuroAI #MLSky
The unts in ANN are actually not a terrible approximation of how real neurons work!
A tiny 🧵.
🧠📈 #NeuroAI #MLSky
Why does anyone have any issue with this?
I've seen people suggesting it's problematic, that neuroscientists won't like it, and so on.
But, I literally don't see why this is problematic...
I've seen people suggesting it's problematic, that neuroscientists won't like it, and so on.
But, I literally don't see why this is problematic...
This would be funny if it weren't sad...
Coming from the "giants" of AI.
Or maybe this was posted out of context? Please clarify.
I can't process this...
Coming from the "giants" of AI.
Or maybe this was posted out of context? Please clarify.
I can't process this...
December 16, 2024 at 8:03 PM
Well said! Great colleagues make this job fun, and I couldn't imagine a better group of them. Thanks for a great 2024, and looking forward to more science in 2025!
sinthlab EoY social! I'm grateful everyday that I get to work with such a kind and intelligent group of individuals.
@mattperich.bsky.social @oliviercodol.bsky.social @anirudhgj.bsky.social
@mattperich.bsky.social @oliviercodol.bsky.social @anirudhgj.bsky.social
December 12, 2024 at 8:49 PM
Well said! Great colleagues make this job fun, and I couldn't imagine a better group of them. Thanks for a great 2024, and looking forward to more science in 2025!
Reposted by Matt Perich
Fun to see this place coming a bit more alive! I tried my hand at a starter pack for neural engineering & computationally-leaning (systems) neuroscience. Super not exhaustive, so if you want to be added (or removed), just ping me. I'm still working on finding folks here.
go.bsky.app/Ty3ftme
go.bsky.app/Ty3ftme
November 12, 2024 at 12:11 AM
Fun to see this place coming a bit more alive! I tried my hand at a starter pack for neural engineering & computationally-leaning (systems) neuroscience. Super not exhaustive, so if you want to be added (or removed), just ping me. I'm still working on finding folks here.
go.bsky.app/Ty3ftme
go.bsky.app/Ty3ftme
Reposted by Matt Perich
We have a new paper on bioRxiv today!
www.biorxiv.org/content/10.1...
Quick thread summary over on Twitter:
x.com/ZachZeisler1...
www.biorxiv.org/content/10.1...
Quick thread summary over on Twitter:
x.com/ZachZeisler1...
Consistent hierarchies of single-neuron timescales in mice, macaques and humans
The intrinsic timescales of single neurons are thought to be hierarchically organized across the cortex. This conclusion, however, is primarily based on analyses of neural responses from macaques. Whe...
www.biorxiv.org
November 1, 2024 at 4:09 PM
We have a new paper on bioRxiv today!
www.biorxiv.org/content/10.1...
Quick thread summary over on Twitter:
x.com/ZachZeisler1...
www.biorxiv.org/content/10.1...
Quick thread summary over on Twitter:
x.com/ZachZeisler1...