@matthiasbrendel.bsky.social
Reposted
Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich:
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Exploring the origins of frequent tau-PET signal in vermal and adjacent regions - European Journal of Nuclear Medicine and Molecular Imaging
Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent...
doi.org
March 18, 2025 at 1:18 PM
Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich:
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Reposted
Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
January 16, 2025 at 6:18 PM
Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted
New paper alert: A two-cutoff CSF Aβ42/40 approach improves Aβ detection in real world clinical settings. CSF Aβ42/40≥7.1 rules out amyloid, while ratios~5.5–7.1 benefit from Aβ PET. Key for Lecanemab stratification. #Alzheimers #Biomarkers
📄read more: doi.org/10.1002/dad2...
📄read more: doi.org/10.1002/dad2...
November 22, 2024 at 12:42 PM
New paper alert: A two-cutoff CSF Aβ42/40 approach improves Aβ detection in real world clinical settings. CSF Aβ42/40≥7.1 rules out amyloid, while ratios~5.5–7.1 benefit from Aβ PET. Key for Lecanemab stratification. #Alzheimers #Biomarkers
📄read more: doi.org/10.1002/dad2...
📄read more: doi.org/10.1002/dad2...
Reposted
Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key!
doi.org/10.1016/j.ne...
doi.org/10.1016/j.ne...
January 12, 2025 at 8:40 AM
Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key!
doi.org/10.1016/j.ne...
doi.org/10.1016/j.ne...
Reposted
Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women
Many thanks also to co-senior Matthias Brendel!
Many thanks also to co-senior Matthias Brendel!
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease | EMBO Molecular Medicine
imageimageThis study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy. ...
doi.org
January 13, 2025 at 4:15 PM
Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women
Many thanks also to co-senior Matthias Brendel!
Many thanks also to co-senior Matthias Brendel!
Reposted
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...
doi.org
November 25, 2024 at 5:59 PM
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...