Thank you to my PhD supervisors at the Center for Computational Biology at Mines Paris and the Computational Systems Biology Group at Institut Curie. Grateful for our collaborators at Institut Necker Enfants Malade and the support from Vaincre La Mucoviscidose. 5/5

If you are interested in CFTR interactors and the consequences of the absence of CFTR on signalling pathways, you can explore the Shiny application at njmmatthieu.shinyapps.io/shinyapp/ for convenient browsing of the CF network. 4/5

Finally, an important contribution of the present work is that the adopted global methodology of the CF context can be used as a common framework for other monogenic diseases. 3/5

We adopted a data-driven systems biology approach to retrieve CF dysregulated signalling pathways. Our findings point to candidate therapeutic targets such as SYK and PI3KCA, for which specific inhibitors are already known. 2/5