Mateusz Wagner
@mateuszwagner.bsky.social
Ph.D. candidate in Smolka Lab; Weill Institute for Cell and Molecular Biology at Cornell University.
Also Phospho-Spectra Misalignment Specialist; Office of Fragmentation Fiascos
Also Phospho-Spectra Misalignment Specialist; Office of Fragmentation Fiascos
Interested in analyzing kinase activity with subcellular spatial resolution? Want to learn more about peptide barcoding?
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
Check out our new biosensor technology to study DDR kinase signaling: ProKAS.
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
November 13, 2025 at 6:53 PM
Interested in analyzing kinase activity with subcellular spatial resolution? Want to learn more about peptide barcoding?
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
@smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!
Reposted by Mateusz Wagner
Check out our new biosensor technology to study DDR kinase signaling: ProKAS.
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
November 13, 2025 at 6:22 PM
Check out our new biosensor technology to study DDR kinase signaling: ProKAS.
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes
ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.
Just published today: rdcu.be/ePNo0
Excited to share our new paper from my time in the Skirycz lab (BTI → MSU)!
We used co-fractionation MS, including a new untargeted approach we developed, to study protein–metabolite interactions.
Co–first author with Jieun Kang — thanks to all involved!
www.cell.com/iscience/ful...
We used co-fractionation MS, including a new untargeted approach we developed, to study protein–metabolite interactions.
Co–first author with Jieun Kang — thanks to all involved!
www.cell.com/iscience/ful...
Mapping protein-metabolite interactions in E. coli by integrating chromatographic techniques and co-fractionation mass spectrometry
Microbiology; Omics; Metabolomics
www.cell.com
June 20, 2025 at 11:24 PM
Excited to share our new paper from my time in the Skirycz lab (BTI → MSU)!
We used co-fractionation MS, including a new untargeted approach we developed, to study protein–metabolite interactions.
Co–first author with Jieun Kang — thanks to all involved!
www.cell.com/iscience/ful...
We used co-fractionation MS, including a new untargeted approach we developed, to study protein–metabolite interactions.
Co–first author with Jieun Kang — thanks to all involved!
www.cell.com/iscience/ful...
Honored to receive an Outstanding Poster Award at the Protein Science Symposium! Huge thanks to the @weillinstitute.bsky.social and @weillcornell.bsky.social for an amazing event—and of course, big shoutout to the @smolka-lab.bsky.social for making the poster results possible!
June 13, 2025 at 1:19 AM
Honored to receive an Outstanding Poster Award at the Protein Science Symposium! Huge thanks to the @weillinstitute.bsky.social and @weillcornell.bsky.social for an amazing event—and of course, big shoutout to the @smolka-lab.bsky.social for making the poster results possible!
Reposted by Mateusz Wagner
Last day repping @smolka-lab.bsky.social with @wjcomstock.bsky.social at the 73nd(?) #ASMS2025! Had an awesome time—already excited for next year!
June 4, 2025 at 11:52 PM
Last day repping @smolka-lab.bsky.social with @wjcomstock.bsky.social at the 73nd(?) #ASMS2025! Had an awesome time—already excited for next year!
Reposted by Mateusz Wagner
New preprint from the lab:
ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM.
Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar.
www.biorxiv.org/content/10.1...
ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM.
Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar.
www.biorxiv.org/content/10.1...
An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks
In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synt...
www.biorxiv.org
May 16, 2025 at 1:02 PM
New preprint from the lab:
ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM.
Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar.
www.biorxiv.org/content/10.1...
ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM.
Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar.
www.biorxiv.org/content/10.1...
It's always sad to see great people leave the lab. Jen, our undergraduate lab member, has finished her degree and her honors thesis.
It's been a pleasure working with you, Jen! All the best in your future career!
It's been a pleasure working with you, Jen! All the best in your future career!
May 18, 2025 at 8:26 PM
It's always sad to see great people leave the lab. Jen, our undergraduate lab member, has finished her degree and her honors thesis.
It's been a pleasure working with you, Jen! All the best in your future career!
It's been a pleasure working with you, Jen! All the best in your future career!
I'm honored to have received the George P. Hess Award from the MBG department and the Outstanding Graduate Teaching Award from CALS. These recognitions wouldn't have been possible without the support of the incredible @smolka-lab.bsky.social and the exceptional students of BIOMG3320.
May 11, 2025 at 2:50 PM
I'm honored to have received the George P. Hess Award from the MBG department and the Outstanding Graduate Teaching Award from CALS. These recognitions wouldn't have been possible without the support of the incredible @smolka-lab.bsky.social and the exceptional students of BIOMG3320.
Reposted by Mateusz Wagner
My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out:
doi.org/10.1016/j.jb...
doi.org/10.1016/j.jb...
February 13, 2025 at 5:24 PM
My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out:
doi.org/10.1016/j.jb...
doi.org/10.1016/j.jb...
Reposted by Mateusz Wagner
Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS.
ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.
We applied it to DDR kinases. Please share.
www.biorxiv.org/content/10.1...
ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.
We applied it to DDR kinases. Please share.
www.biorxiv.org/content/10.1...
December 17, 2024 at 2:10 PM
Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS.
ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.
We applied it to DDR kinases. Please share.
www.biorxiv.org/content/10.1...
ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.
We applied it to DDR kinases. Please share.
www.biorxiv.org/content/10.1...