‘Genetic Risk Effects on Psychiatric Disorders Act in Sets’, the title of our new preprint on
@medrxivpreprint.bsky.social! This huge collaborative effort advances our understanding of psychiatric genetic architecture and emphasizes the importance of looking beyond additive effects. 🧵1/n; 🧪👩🏽‍🔬🧬

🎉 Congrats on the successful MoHAD Postdoc/Early Researcher Day, organized by postdocs @martijnrutten.bsky.social & @jamilnehme.bsky.social from our lab! An inspiring event with career talks, great presentations, lively discussions, and creative brainstorming to foster collaboration. 🚀

Great first Joint Meeting of the UMCG’s three Research Institutes! @umcgroningen.bsky.social #umcgresearch #MoHAD

CDK4/6 inhibitors transiently induce a senescence-like state in breast cancer cells, which however cannot be eliminated by senolytics - but Marco Demaria, Boshi Wang and coworkers @demarialab.bsky.social find that they are instead sensitive to lysosomotropic agents!
www.embopress.org/doi/full/10....

🔬 Journal Club
Today, our Master’s student Vlaicu presented a fascinating topic: Senescent cells evade NK cells by upregulating GD3—blocking GD3 restores immune clearance, reducing fibrosis and aging damage. 🛡️🔬 #Aging #Senescence #Immunotherapy www-nature-com.proxy-ub.rug.nl/articles/s43...

🔬 Journal Club

This week, @martijnrutten.bsky.social presented "Exosomal miR-302b rejuvenates aging mice" (Bi et al., Cell Metab, 2025).
🧬 miR-302b rescues proliferative arrest in senescent cells
🐭 Improves tissue function in aged mice

Great discussion on the possibility of reversing senescence!

🚨 Big news! 🚨 Our lab's latest paper by Jamil Nehme (@jamilnehme.bsky.social) is out now:
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer.
Check it out! (doi.org/10.1038/s443...) Congrats, Jamil! #CancerResearch #CDK46 #BreastCancer