Marqusee Lab
@marquseelab.bsky.social
The Marqusee Lab @UCBerkeley uses #biophysics to study #proteinfolding in basic and cellular contexts. Account is student/postdoc run. All posts in kcal/mol.
Congrats to our current postdoc Amir on his latest publication with the Shakhnovich and Rodnina labs! Check out this thread about their really interesting study, combining all-atom simulation with experiment to reveal a protein's co-translational folding pathway at an atomistic level of detail
Really thrilled to share my latest co-first author publication in Science Advances, the culmination of a project from my PhD with Eugene Shakhnovich and a wonderful collaboration with the lab of Marina Rodnina
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Cotranslational protein folding through non-native structural intermediates
Early folding intermediates form via non-native contacts and are reshaped by chaperones during protein synthesis on the ribosome.
www.science.org
September 6, 2025 at 4:42 PM
Congrats to our current postdoc Amir on his latest publication with the Shakhnovich and Rodnina labs! Check out this thread about their really interesting study, combining all-atom simulation with experiment to reveal a protein's co-translational folding pathway at an atomistic level of detail
So thrilled to share that Susan was selected as a 2025 Protein Society Fellow!
Congrats to MCB's Susan Marqusee @marquseelab.bsky.social on being selected as a 2025 Protein Society Fellow @proteinsociety.bsky.social! 👏🎉
September 6, 2025 at 4:36 PM
So thrilled to share that Susan was selected as a 2025 Protein Society Fellow!
Excited to share our latest paper led by our talented former PhD student Miriam Hood
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Exploring the sequence and structural determinants of the energy landscape from thermodynamically stable and kinetically trapped subtilisins: ISP1 and SbtE
A protein's energy landscape, all accessible conformations, their populations, and dynamics of interconversion, is encoded in its primary sequence. While how this sequence encodes a protein's native ...
onlinelibrary.wiley.com
August 23, 2025 at 3:58 PM
Excited to share our latest paper led by our talented former PhD student Miriam Hood
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Come check out presentations by the Marqusee lab at the 39th Protein Society Annual Symposium (@proteinsociety.bsky.social). Darren Kahan just gave an awesome talk on his work on IDPs.
June 26, 2025 at 5:56 PM
Come check out presentations by the Marqusee lab at the 39th Protein Society Annual Symposium (@proteinsociety.bsky.social). Darren Kahan just gave an awesome talk on his work on IDPs.
Pleased to share a manuscript by our star former grad student, Sara Volz, showing the power of HDX-MS to probe folding intermediates of γD crystallin under native conditions. This approach could shed future light on cataract-linked aggregation. Thanks @alexguseman.bsky.social and the Gronenborn lab
February 4, 2025 at 4:25 AM
Pleased to share a manuscript by our star former grad student, Sara Volz, showing the power of HDX-MS to probe folding intermediates of γD crystallin under native conditions. This approach could shed future light on cataract-linked aggregation. Thanks @alexguseman.bsky.social and the Gronenborn lab
Check out Sophie's new preprint on bioRxiv in collaboration with Magnus Hoffmann's lab where we conduct HDX-MS on SARS-CoV-2 spike proteins displayed on eVLPs to understand the dynamics of natural and engineered variants. 1/7 biorxiv.org/content/10.1...
The Interplay of Furin Cleavage and D614G in Modulating SARS-CoV-2 Spike Protein Dynamics
We report a detailed analysis of the full-length SARS-CoV-2 spike dynamics within a native-like membrane environment and variants inaccessible to studies on soluble constructs by conducting hydrogen-d...
biorxiv.org
January 30, 2025 at 9:56 PM
Check out Sophie's new preprint on bioRxiv in collaboration with Magnus Hoffmann's lab where we conduct HDX-MS on SARS-CoV-2 spike proteins displayed on eVLPs to understand the dynamics of natural and engineered variants. 1/7 biorxiv.org/content/10.1...