New Video & Blog Post: Beta-Cell Dysfunction: The Overlooked Cause of Type 2 Diabetes, and How to Measure It

Glucose intolerance, as in prediabetes or type 2 diabetes, is always the consequence of insufficient insulin secretion for a given level of insulin sensitivity.

Effective Weight Loss Diets Have Common Characteristics!

In my newest video, I speak with Dr. Andreas Eenfeldt about what makes a diet highly satiating, weight loss medications, the common characteristics of all effective weight-loss diets, and more:

loom.ly/V_VI-0Q

Third, the LDL-cholesterol concentration is a major determinant of the cholesterol content in small, dense LDL particles.

The green person has a 65% lower overall LDL-cholesterol concentration, and as a result, also much less small, dense LDL-cholesterol than the other two.

Second, no one has only small, dense, or only large, buoyant LDL particles.

The image below shows the distribution of LDL cholesterol in 38 lipoprotein classes, including 12 different subclasses of LDL.

The red and blue person have the exact same overall LDL cholesterol level.

A common claim online is that the number of total LDL particles or the LDL-cholesterol concentration does not matter for ASCVD and that only small, dense LDL particles are atherogenic.

Small, dense LDL particles are those that are smaller and denser than other LDL particles.

Low-density lipoprotein (LDL) particles span a range in terms of both density (1.02 - 1.06 g/mL) and size (18 - 25 nm).

The cholesterol concentration in all LDL particles is a commonly measured risk factor for atherosclerotic cardiovascular disease (ASCVD).

A common claim online is that only small, dense LDL particles are atherogenic, and that large, buoyant, or "fluffy", LDL particles can safely be ignored.

What is all of that about?

What does the scientific evidence say?

A 🧵