Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday

Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...

Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social

Villus cells seem to be mechanically predisposed to extrude..
We're working hard to nail down these mechanisms, from the initial impulse for extrusion to its execution through out-of-plane #torque generation. More to come!

@xaviertrepat.bsky.social lab
@ibecbarcelona.eu
@embo.org LTFellowship

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

It's been 2 mere months since the magnificent #CellBio24 @ascbiology.bsky.social @embo.org in San Diego and my first ever trip to the US. It's hard to believe the amount of chaos that's happened since then..

Throwback with @paulinastrzyz.bsky.social Karina Pombo-Garcia, Chris Schmied, Jeff Woodruff

We have a new #stopdoing #science meme, courtesy of Miquel Bosch Padros from the @xaviertrepat.bsky.social lab. Late for #mechanobiology Monday, but here to stay on your lab meme boards forever.

"Politics aside (ha! as if!)", I don't think these will ever get old for me, but they do shine extra bright these days.
"..." Stolen from @harmitmalik.bsky.social

#biology #stopdoing #science