Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday

Part of our TrepatLab preprint: www.biorxiv.org/content/10.1...

Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social

They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n
www.biologists.com/grants/

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

Scientific collaborations come in many flavors & are fun because they expose you to new areas of science. That was definitely the case for this paper, out today. We were definitely in the passenger seat but it was fun to go along for the ride 1/n
rdcu.be/euiZB.

How to turn a layer of fibroblasts into a tulip 🌷?

Check out our new pre-print on shape-programmable living surfaces.

Led by @pauguillamat.bsky.social‬

www.biorxiv.org/content/10.1...

Beautiful story from the Krndija lab, tackling the unexpected challenges of complex epithelia. They show side-effects (or are they?) of building an epithelium out of distinct cell types, with junctional fractures at the heterotypic interface.
Is there any reinforcement of 3CJunctions?

... and a few minutes ago our Chart-Checklist came out in @natcellbio.nature.com 🥳🎉

Gift link for #TCTeAC:
rdcu.be/eqPpi

www.nature.com/articles/s41...

Very useful thread from the best fan club @epimechfc.bsky.social on different (newish) image analysis software. Have a look, add the ones you use!
Is it time for a review article?

It's been 2 mere months since the magnificent #CellBio24 @ascbiology.bsky.social @embo.org in San Diego and my first ever trip to the US. It's hard to believe the amount of chaos that's happened since then..

Throwback with @paulinastrzyz.bsky.social Karina Pombo-Garcia, Chris Schmied, Jeff Woodruff

We have a new #stopdoing #science meme, courtesy of Miquel Bosch Padros from the @xaviertrepat.bsky.social lab. Late for #mechanobiology Monday, but here to stay on your lab meme boards forever.

"Politics aside (ha! as if!)", I don't think these will ever get old for me, but they do shine extra bright these days.
"..." Stolen from @harmitmalik.bsky.social

#biology #stopdoing #science

Please welcome @scadsai.bsky.social on bluesky! We at ScaDS.ai are a federally funded artificial intelligence research center with headquarters in Dresden and Leipzig, Germany!

Beautiful findings, showing that at a critical tissue density, YAP is heterogeneously expressed in intestinal cells, leading to all sorts of responses that help regeneration. Well done Connie @cschwayer.bsky.social and all ✨

See you in San Diego old and new friends! Join me and my talk in the organoid subgroup on Wednesday at 9:15 AM for a dive into the elements that drive intestinal cell extrusion. It's a very pretty, fundamental story ✨

I think this will be fun and very useful! Writing well is thinking well #devbiolwriteclub