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mareikealbert.bsky.social
@mareikealbert.bsky.social
Interested in gene regulation, epigenetics, neocortex development and evolution
Proud to see your story featured on the cover of #Neuron! 🤩

Along with a great #preview from Fides Zenk lab @epign.bsky.social

www.cell.com/neuron/abstr...
September 19, 2025 at 3:56 PM
Intriguingly, pharmacological PRC2 inhibition in human cortical organoids induces increased production of the ECM components Syndecan 1 and Laminin alpha 1. (9/11)
July 23, 2025 at 11:33 AM
Our cell type-specific profiling of the genome-wide H3K27me3 profile not only identified neuronal differentiation, but also extra-cellular matrix (ECM) genes as targets of PRC2. (7/11)
July 23, 2025 at 11:33 AM
We found that loss of H3K27me3 in human cortical organoids induces a shift of neural progenitor cell proliferation towards differentiation that results in reduced organoid size. (5/11)
July 23, 2025 at 11:33 AM
Here, we performed pharmacological inhibition of PRC2 in human cortical organoids from week 3 to 8, leading to a near complete loss of H3K27me3, and studied NPC behaviour. (4/11)
July 23, 2025 at 11:33 AM
We apply an innovative, highly multiplexed approach, Epi-CyTOF, to study > 30 epigenetic modifications at single-cell level in the human developing neocortex. We identify H3K27me3, deposited by PRC2, as the modification with the strongest cell type-specific enrichment. (2/11)
July 23, 2025 at 11:33 AM
How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.

@crtd-tud.bsky.social @cp-neuron.bsky.social

www.sciencedirect.com/science/arti...

A thread below 👇
July 23, 2025 at 11:33 AM
Metabolic-epigenetic interplay emerges as a novel direction for studying the timing of cortical development, and brain organoids offer exciting new experimental approaches.
March 28, 2025 at 11:12 AM
Metabolic and epigenetic regulation are tightly linked. The deposition and removal of epigenetic marks, including DNA and histone modifications, requires substrates provided by a plethora of metabolic pathways.
March 28, 2025 at 11:12 AM
Cell metabolism differs between cell types and species in cortical development.
March 28, 2025 at 11:12 AM
Mutations in various histone modifiers cause developmental disorders linked to impaired brain development. These disorders highlight the importance of activating and repressive histone modifications in controlling human cortical development.
March 28, 2025 at 11:12 AM
The neocortexes of mice and humans differ in various respects, including developmental timing. Epigenetic regulation has emerged as an important mechanism to control developmental timing.
March 28, 2025 at 11:12 AM
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!

www.biorxiv.org/content/10.1...
March 13, 2025 at 10:11 AM
How do different #PRC1 complexes contribute to the regulation of #NSC fate? Side-by-side comparison of canonical and non-canonical PRC1 in #proliferation and #differentiation.

Our study is now published:
www.life-science-alliance.org/content/8/4/...

By Janine Hoffmann @crtd-tud.bsky.social
February 12, 2025 at 10:17 AM
Planning to attend the German Neuroscience Society Meeting in March 2025 in Göttingen? Consider joining the Satellite Symposium of the Schram Foundation on 25th March 2025!

"THE EVOLUTIONARY TAPESTRY OF COGNITION"
Great lineup of speakers! No registration fee!

www.schram-stiftung.de/symposien
December 11, 2024 at 8:50 AM
Interested in using sliced cortical organoids for functional studies? Check out our step-by-step protocol for electroporation!

app.jove.com/t/67598/elec...

By our incredibly skilled technician Annika Kolodziejczyk 🤩
December 3, 2024 at 3:40 PM
💫 Join us! We are looking for an enthusiastic #postdoc! Are you excited about #epigenetics, #neocortex development, neurodevelopmental #disorders, #evolution, #organoids?
Apply until 27 Nov 2024! 4-year fully funded position

tu-dresden.de/vacancy/11767
November 18, 2024 at 8:01 PM