@mareikealbert.bsky.social
Interested in gene regulation, epigenetics, neocortex development and evolution
Thank you for highlighting our work and putting into perspective! ☺️
September 17, 2025 at 9:43 PM
Thank you for highlighting our work and putting into perspective! ☺️
Huge congrats 🥳 So well deserved!
September 6, 2025 at 7:20 PM
Huge congrats 🥳 So well deserved!
📣 Proud of this fantastic work by two amazing PhD students Nora Ditzer and Ezgi Senoglu from @crtd-tud.bsky.social. 🥳 👏 Huge thanks to all co-authors! Enjoy the read. (11/11)
July 23, 2025 at 11:33 AM
📣 Proud of this fantastic work by two amazing PhD students Nora Ditzer and Ezgi Senoglu from @crtd-tud.bsky.social. 🥳 👏 Huge thanks to all co-authors! Enjoy the read. (11/11)
Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex. (10/11)
July 23, 2025 at 11:33 AM
Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex. (10/11)
Intriguingly, pharmacological PRC2 inhibition in human cortical organoids induces increased production of the ECM components Syndecan 1 and Laminin alpha 1. (9/11)
July 23, 2025 at 11:33 AM
Intriguingly, pharmacological PRC2 inhibition in human cortical organoids induces increased production of the ECM components Syndecan 1 and Laminin alpha 1. (9/11)
Our findings are especially interesting considering previous results from the Hippenmeyer lab, where PRC2 knockout in individual cells of the mouse cortex suggested a non-cell autonomous mechanism for the regulation of NPC fate decisions by PRC2. (8/11)
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
www.science.org
July 23, 2025 at 11:33 AM
Our findings are especially interesting considering previous results from the Hippenmeyer lab, where PRC2 knockout in individual cells of the mouse cortex suggested a non-cell autonomous mechanism for the regulation of NPC fate decisions by PRC2. (8/11)
www.science.org/doi/epdf/10....
www.science.org/doi/epdf/10....
Our cell type-specific profiling of the genome-wide H3K27me3 profile not only identified neuronal differentiation, but also extra-cellular matrix (ECM) genes as targets of PRC2. (7/11)
July 23, 2025 at 11:33 AM
Our cell type-specific profiling of the genome-wide H3K27me3 profile not only identified neuronal differentiation, but also extra-cellular matrix (ECM) genes as targets of PRC2. (7/11)
Whereas a recent study from the Treutlein lab and @epign.bsky.social revealed a role of PRC2 in regulating the exit from pluripotency, we now dissect the role of PRC2 within the neural lineage after the initial cell fate commitment. (6/11)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems - Nature Neuroscience
The mechanisms underlying human cell diversity are unclear. Here the authors provide a single-cell epigenome map of human neural organoid development and dissect how epigenetic changes control cell fa...
www.nature.com
July 23, 2025 at 11:33 AM
Whereas a recent study from the Treutlein lab and @epign.bsky.social revealed a role of PRC2 in regulating the exit from pluripotency, we now dissect the role of PRC2 within the neural lineage after the initial cell fate commitment. (6/11)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We found that loss of H3K27me3 in human cortical organoids induces a shift of neural progenitor cell proliferation towards differentiation that results in reduced organoid size. (5/11)
July 23, 2025 at 11:33 AM
We found that loss of H3K27me3 in human cortical organoids induces a shift of neural progenitor cell proliferation towards differentiation that results in reduced organoid size. (5/11)
Here, we performed pharmacological inhibition of PRC2 in human cortical organoids from week 3 to 8, leading to a near complete loss of H3K27me3, and studied NPC behaviour. (4/11)
July 23, 2025 at 11:33 AM
Here, we performed pharmacological inhibition of PRC2 in human cortical organoids from week 3 to 8, leading to a near complete loss of H3K27me3, and studied NPC behaviour. (4/11)
These results beautifully align with a recent study from the Studer lab where PRC2 was shown to contribute to an epigenetic barrier that mediates the protracted maturation of human neurons compared to other species. (3/11)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An epigenetic barrier sets the timing of human neuronal maturation - Nature
The slow maturation of human neurons is regulated by epigenetic modification in nascent neurons, mediated by EZH2, EHMT1, EHMT2 and DOT1L.
www.nature.com
July 23, 2025 at 11:33 AM
These results beautifully align with a recent study from the Studer lab where PRC2 was shown to contribute to an epigenetic barrier that mediates the protracted maturation of human neurons compared to other species. (3/11)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We apply an innovative, highly multiplexed approach, Epi-CyTOF, to study > 30 epigenetic modifications at single-cell level in the human developing neocortex. We identify H3K27me3, deposited by PRC2, as the modification with the strongest cell type-specific enrichment. (2/11)
July 23, 2025 at 11:33 AM
We apply an innovative, highly multiplexed approach, Epi-CyTOF, to study > 30 epigenetic modifications at single-cell level in the human developing neocortex. We identify H3K27me3, deposited by PRC2, as the modification with the strongest cell type-specific enrichment. (2/11)