This project initially began in the lab of the late great Michael R. Green, with the idea of performing a CRISPR screen to identify novel, targetable regulators of STING in tumor cells that often silence STING expression and as such are not responsive to STING agonists.

This month our lab is celebrating 5 years! Couldn't be more thrilled with and proud of the group we have. Great scientists and human beings all around. Also super excited about the science coming out of the lab. Stay tuned for a few new studies dropping in the upcoming weeks.

Congrats to Haruka from the Atukorale and Ruscetti labs for passing her qualifying exam to become a Ph.D. candidate yesterday! We are proud mentors and can't wait to see what you can accomplish through engineering LNPs for drug delivery in pancreatic cancer!

Always wonderful to see how our lab family grows each year. Happy Holidays from the Ruscetti and @pitarresilab.bsky.social groups!

First post on @bsky.app! Excited to engage with the scientific community, share our lab's research on tumor immunology and cellular senescence, and highlight the work and accomplishments of our inspiring lab members on this platform.