Great findings indeed, I have so many questions 🤩! I’m intrigued that TLS loss precedes the loss of Polδ. While the latter could be host control, the former shouldn’t. Like @morielab.bsky.social, I wonder how far can Polδ go alone, and what does the plant supply for efficient genome duplication!

Looking forward to reading this!!

They are so lucky to have you!!

Thank you Sebastian! 😊

Grazie Gianni! Spero ci si vede presto che ti racconto del resto!

Big shout-out to @reviewcommons.org for finding four thorough, constructive reviewers, and to @molsystbiol.org & @embopress.org for a smooth journal transition and editorial process!

Here is the link to the full and open-access article: www.embopress.org/doi/full/10....

We are working on making it available soon as a tool (RepliFlow). In the meantime, if you are interested in applying it to your dataset (any organism welcome), feel free to get in touch. Feedback on the preprint is also very welcome!

To illustrate the modular nature of our framework, we propose a minimal model of DNA replication that does not account for the spatial configuration of DNA, and still accurately infers microscopic properties such as origin firing rates and replication fork speeds.

We show that from population-wide DNA content alone (without any labeled nucleotides) it is possible to uncover not just cell cycle phase durations but also how DNA replication unfolds inside cells (alpha in the picture below)