To illustrate the modular nature of our framework, we propose a minimal model of DNA replication that does not account for the spatial configuration of DNA, and still accurately infers microscopic properties such as origin firing rates and replication fork speeds.

We show that from population-wide DNA content alone (without any labeled nucleotides) it is possible to uncover not just cell cycle phase durations but also how DNA replication unfolds inside cells (alpha in the picture below)

🗞️New preprint out! Together with Adolfo Alsina and Pablo Sartori (both not on here), we combined experiments and theory to extract detailed information on DNA replication dynamics from simple DNA content flow cytometry data.
www.biorxiv.org/content/10.1...

🎺Please RT! We have a funded #Postdocposition in our lab at @IGCiencia in Portugal 🇵🇹🇪🇺! Come and join us in exploring the wonders and evolution of genome maintenance processes, and engage with the extended #LifeScience community in #Lisbon! Details here: fumalab.github.io/join