It was like Chester cheetah, except cigarettes are slightly worse for you.

Could literally go on for hours.

... I'd watch that.

Could you imagine if they changed diagnostic criteria and eliminated an outdated diagnoses and brought those people under the same diagnosis while educating people better to where people who are older and didn't get diagnosed as kids got diagnosed later in life? That's what happened.

Bret. The call is coming from inside the house.

Not as much as you think and far more than you've done. Can't help but notice you dodge my question about your education. Wonder why that is.

If this were about levels of evidence, what I would accept would be evidence that is conclusive as it is for the drugs we understand the mechanisms for. X does x for x reason. Look up the moa of metoprolol, a beta blocker, versus ketamine. You'll see the difference.

There are many drugs we understand the mechanisms for. There are many we don't. This person clearly has a deficit in knowing what a mechanism of action is and why the op and me are saying this and I'm asking their education to know how to explain this to them.

This isn't a god of the gaps. This is a knowledge deficit. I'm literally studying all of this currently. If we lack a full understanding of how a mechanism of action works in a medication and why, we say the mechanism is unknown and give a brief explanation of what we know a drug is doing.

What's your background of education?

In other words, if we knew the mechanism better, we could synthesize a formulation specifically to treat depression without the drawbacks of using the same formulation that treats pain. Because we don't yet know that, we can't do that. This is incredibly important to understanding whats being said.

In
order to fully harness the emerging potential of fast neurotrans-
mission in neurotherapies, it will be critical to uncover novel
therapeutics to target fast neurotransmission that do not impair its
fundamental function in sensory processing as well as learning
and memory processes."

This line from the nature study you posted explains well the issue you're not getting. "Today, ketamine action and the role of fast glutamatergic
neurotransmission in the pathogenesis and treatment of mood
disorders present a new set of opportunities and challenges. 1/2

All the KNOWN mechanisms. Meaning there's more mechanisms we don't know and what we do is limited.

Again, from the conclusion. "It is most probable that many different pathways contribute to ketamine’s actions, and it is currently difficult to narrow down which mechanisms are most dominant over others to produce this effect, due to the widespread nature of ongoing research."

First line of the conclusion "The synthesized literature demonstrates the pathophysiology of depression and TRD, and ketamine’s antidepressant actions to be complex, and not yet fully explored."

Prove it. Because I'm literally in nursing school and have access to the most up to date information on pharmacology and all I'm seeing is that eve. It's antidepressant mechanisms are unknown.