This is an image that has haunted me since I was a child because it captures something truly inherent to the human experience. We can get used to anything. A new blog post about habituation—it's been a while, needed to get un-used to a few things. maorknafo.com/reducible-beau…🧪

Waddington's landscape contamination in the lab today!
🍄📷🧪

Stress seldom encountered does not require such a network and its costly upkeep, so strategies such as #bethedging are sufficient and could be refined upon recurring exposures. 11/13

We think then that #creativity in response or stress-induced variability could arise when cells have a robust, redundant network of responses, allowing multiple adaptive avenues to be explored and explored. 10/13

Our hypothetical model of what is going on is quite counterintuitive. NaCl, as it is a very exotic stress, has a minimal proteomic response attributed to it, while pH is an integral part of the yeast way of life. 9/13

We wanted to probe this phenomenon deeper, so we utilized our #gUMIBEAR barcoding and tracking method to see the population's lineage dynamics at high temporal resolution. 7/13

But rather multimodal distributions, exemplifying what we think are multi-state phenotypes. We used #ShannonEntropy to portray these populations accurately and plotted them against the stress in various insult levels. 5/13

Many works have described the function of #noise and its relationship to #stress, but we wanted to quantify this relationship in a way that has yet to be widely measured. This required many levels of stressful perturbations. 2/13

A new #preprint! Variability is strange, right? Especially when it arises in the background of an identical genetic background. Why would cells, having the same machinery, regulation, and environment, behave differently? Why would there be #noise? 1/13 rb.gy/45y36m

Terrarium going a bit crazy these past weeks. Constantly changing. 🍄📷

ganoderma sp.? 🧪🍄📷
"What an organism feeds upon is negative entropy. Or, to put it less paradoxically, the essential thing in metabolism is that the organism succeeds in freeing itself from all the entropy it cannot help producing while alive"

Erwin Schrödinger, What is Life?

Guys, guys, am I just seeing things or is this a budding yeast cell???
Great song BTW 🧪🍄

Mine is kinda long... But beautiful.

Starting to look like autumn (finally). False parasol? 🧪🍄

🧪🧪New blog post!
How (and why) do organisms optimize tasks, and why are they flat about it? The use of Mutual Information in Pareto fronts and slimy aliens.🌌👾📊
maorknafo.com/reducible-beau…
In the comments, I'll link to the previous posts, which I think are helpful (and cool😆).

From primer design to analytical pipelines, the used practices are governed by field-specific "knowledge", introducing significant biases and blind spots. In CoSMIC, we present a bottom-up approach to make microbiome-surveying projects much more accurate and reliable. 3/8

Microbiome research, specifically surveying the microbial community, relies heavily on the partial sequencing of the 16s rRNA gene and using those short fragments as a proxy for bacteria present in the sample, which is problematic on many levels. 2/8