Manuel Thery
@manuelthery.bsky.social
cytoskeleton self-organization / shape, patterns and symmetry / minimal and artificial cells / biophysics teacher @ ESPCI ParisTech
www.cytomorpholab.com
www.cytomorpholab.com
@ghinabadih.bsky.social and Laetitia Kurzawa from CytoMorphoLab concluded that "contractile forces direct the chiral swirling of cells".
November 21, 2025 at 1:15 PM
@ghinabadih.bsky.social and Laetitia Kurzawa from CytoMorphoLab concluded that "contractile forces direct the chiral swirling of cells".
What if one cell of the doublet prefer the counter-clockwise direction? The strongest imposes its bias.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
November 21, 2025 at 1:11 PM
What if one cell of the doublet prefer the counter-clockwise direction? The strongest imposes its bias.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
We found that it takes only two cells for the bias to take place.
Although now they are only 60% to chose the clockwise direction.
Although now they are only 60% to chose the clockwise direction.
November 21, 2025 at 1:09 PM
We found that it takes only two cells for the bias to take place.
Although now they are only 60% to chose the clockwise direction.
Although now they are only 60% to chose the clockwise direction.
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
November 21, 2025 at 1:07 PM
The law of the jungle.
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
Interactions of cells in a collective lead to global rotation.
In 80% of the case HUVEC cells turn clockwise.
How many cells does it take for this to happen?
nine fold symmetry
those-who-know know what i mean
those-who-know know what i mean
November 1, 2025 at 12:53 PM
nine fold symmetry
those-who-know know what i mean
those-who-know know what i mean
Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors.
#morphogenesis
#morphogenesis
October 15, 2025 at 10:24 AM
Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors.
#morphogenesis
#morphogenesis
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
I see intraflagellar transport and dynamic steady states in living systems in this work by www.perry-cooper.com/about
Should we think of the bias in intracellular transports by "rewards"?
Should we think of the bias in intracellular transports by "rewards"?
October 10, 2025 at 2:02 PM
I see intraflagellar transport and dynamic steady states in living systems in this work by www.perry-cooper.com/about
Should we think of the bias in intracellular transports by "rewards"?
Should we think of the bias in intracellular transports by "rewards"?
response to bottom clap 🤩
October 10, 2025 at 1:36 PM
response to bottom clap 🤩
Each cube can emit a light and sound to tell its neighbours it has heard something.
Check www.scenocosme.com/reactive_mat... for more details on this reactive matter.
Check www.scenocosme.com/reactive_mat... for more details on this reactive matter.
October 10, 2025 at 1:34 PM
Each cube can emit a light and sound to tell its neighbours it has heard something.
Check www.scenocosme.com/reactive_mat... for more details on this reactive matter.
Check www.scenocosme.com/reactive_mat... for more details on this reactive matter.
What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
October 7, 2025 at 3:08 PM
What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
Beautiful work Sara ! It reminds me our observations of nuclear deformation by microtubules driving chromatin remodeling and hematopoietic stem cell differentiation. But here you investigated the mechanism much further than we did 😅. The osmotic path you uncovered is fascinating !
September 29, 2025 at 5:31 PM
Beautiful work Sara ! It reminds me our observations of nuclear deformation by microtubules driving chromatin remodeling and hematopoietic stem cell differentiation. But here you investigated the mechanism much further than we did 😅. The osmotic path you uncovered is fascinating !
After so many years we keep
on drawing circles, lines, asters and arrows.
on drawing circles, lines, asters and arrows.
September 29, 2025 at 10:14 AM
After so many years we keep
on drawing circles, lines, asters and arrows.
on drawing circles, lines, asters and arrows.
Blood cancer cells fail to polarize.
Lindsey Goff commented on this in her post about the Biomedical Picture of the Day: bpod.org.uk and named it : "inaction on interaction".
Lindsey Goff commented on this in her post about the Biomedical Picture of the Day: bpod.org.uk and named it : "inaction on interaction".
June 30, 2025 at 1:08 PM
Blood cancer cells fail to polarize.
Lindsey Goff commented on this in her post about the Biomedical Picture of the Day: bpod.org.uk and named it : "inaction on interaction".
Lindsey Goff commented on this in her post about the Biomedical Picture of the Day: bpod.org.uk and named it : "inaction on interaction".
today we are revisiting the good old Gundersen and Bulinski experiments about microtubules stability and modifications in migrating cells.
May 27, 2025 at 11:40 AM
today we are revisiting the good old Gundersen and Bulinski experiments about microtubules stability and modifications in migrating cells.
Anne-Betty N'diaye from our #CytoMorphoLab received the best poster prize for her cell monsters at @embo.org workshop on Cellular Matters !
May 22, 2025 at 8:41 AM
Anne-Betty N'diaye from our #CytoMorphoLab received the best poster prize for her cell monsters at @embo.org workshop on Cellular Matters !
Let's allow the MT to move now. It moves and propagates its pattern of motors.
Since there are more blue motors (minus end directed), the MT is moving and ... can now encounter another MT !
Since there are more blue motors (minus end directed), the MT is moving and ... can now encounter another MT !
May 9, 2025 at 11:12 AM
Let's allow the MT to move now. It moves and propagates its pattern of motors.
Since there are more blue motors (minus end directed), the MT is moving and ... can now encounter another MT !
Since there are more blue motors (minus end directed), the MT is moving and ... can now encounter another MT !
MT efforts to organize space is more clear with more motors and less diffusion. Now you see the point: MTs generate local accumulation of motors, which push/pull the microtubule accordingly. MTs act on motors which act on MTs. The stage is set for something to happen.
May 9, 2025 at 10:59 AM
MT efforts to organize space is more clear with more motors and less diffusion. Now you see the point: MTs generate local accumulation of motors, which push/pull the microtubule accordingly. MTs act on motors which act on MTs. The stage is set for something to happen.
It becomes even more exciting when the transient imbalance of the two opposite motors can propel the microtubule accordingly.
May 7, 2025 at 11:53 AM
It becomes even more exciting when the transient imbalance of the two opposite motors can propel the microtubule accordingly.
This desperate attempt to sort diffusing motors is a fight against entropy and disorder. Life shall win.
Numerical simulation by Floran Lavrilleux.
Numerical simulation by Floran Lavrilleux.
May 6, 2025 at 10:38 AM
This desperate attempt to sort diffusing motors is a fight against entropy and disorder. Life shall win.
Numerical simulation by Floran Lavrilleux.
Numerical simulation by Floran Lavrilleux.
I can't wait to attend this meeting and present our work on building cell architecture with the shape of the @museeorsay.bsky.social !
April 3, 2025 at 5:38 AM
I can't wait to attend this meeting and present our work on building cell architecture with the shape of the @museeorsay.bsky.social !
Following general
introduction, we try to understand how the famous CellPose works.
www.nature.com/articles/s41...
introduction, we try to understand how the famous CellPose works.
www.nature.com/articles/s41...
March 20, 2025 at 2:13 PM
Following general
introduction, we try to understand how the famous CellPose works.
www.nature.com/articles/s41...
introduction, we try to understand how the famous CellPose works.
www.nature.com/articles/s41...
Deep learning practical workshop in the Vercors. CytoMorpho goes AI !
March 20, 2025 at 12:47 PM
Deep learning practical workshop in the Vercors. CytoMorpho goes AI !
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !
Please Repost 🙏 thanks !
March 5, 2025 at 5:20 PM
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required.
Please Repost 🙏 thanks !
Please Repost 🙏 thanks !
Destruction is key to life.
It allows system permanent reassembly and the sharing of ressources. Competition is less fierce when sharing ☮️
@alexandra-colin.bsky.social captured this in a minimal system 🤩
See her recent publication in @currentbiology.bsky.social
authors.elsevier.com/a/1kPbA3QW8S...
It allows system permanent reassembly and the sharing of ressources. Competition is less fierce when sharing ☮️
@alexandra-colin.bsky.social captured this in a minimal system 🤩
See her recent publication in @currentbiology.bsky.social
authors.elsevier.com/a/1kPbA3QW8S...
January 10, 2025 at 11:23 AM
Destruction is key to life.
It allows system permanent reassembly and the sharing of ressources. Competition is less fierce when sharing ☮️
@alexandra-colin.bsky.social captured this in a minimal system 🤩
See her recent publication in @currentbiology.bsky.social
authors.elsevier.com/a/1kPbA3QW8S...
It allows system permanent reassembly and the sharing of ressources. Competition is less fierce when sharing ☮️
@alexandra-colin.bsky.social captured this in a minimal system 🤩
See her recent publication in @currentbiology.bsky.social
authors.elsevier.com/a/1kPbA3QW8S...