Manuela Raffatellu
@manuelar.bsky.social
From Sardinia to California - Professor at UCSD - Love microbes. Find me by the ocean or at my Pilates studio
Pinned
Manuela Raffatellu
@manuelar.bsky.social
· Nov 14
Hi everyone, this is my first post here and it’s great to get so many new connections. My lab works on host-pathogen interaction, particularly in the context of Salmonella infection, mucosal immunity, microbiota-host interaction, microbial competition. We are a fun, diverse, enthusiastic group.
Reposted by Manuela Raffatellu
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Reposted by Manuela Raffatellu
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Manuela Raffatellu
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 5, 2025 at 4:10 PM
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
Reposted by Manuela Raffatellu
Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.
Commensal yeast promotes Salmonella Typhimurium virulence - Nature
Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.
www.nature.com
September 3, 2025 at 4:32 PM
Excited to share our new publication, out today in Nature! www.nature.com/articles/s41.... @kanchanj.bsky.social led this fascinating fungal-bacterial interaction project. We are grateful for our wonderful collaborators Brian Peters and David Underhill.
Reposted by Manuela Raffatellu
Airport reunion 🥳 Loved catching up with my postdoctoral mentor @manuelar.bsky.social at the airport during her layover in Munich ☀️❣️
August 10, 2025 at 7:37 AM
Airport reunion 🥳 Loved catching up with my postdoctoral mentor @manuelar.bsky.social at the airport during her layover in Munich ☀️❣️
This is so cool, congrats @lozanzi.bsky.social and team! Important implications for infection and IBD
Online now: Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidized phospholipids accumulate upon microbial encounter, epigenetically suppress IL-10, and exacerbate harmful inflammation. Thus, targeting oxPLs represents a therapeutic strategy to treat deranged inflammation after infection.
dlvr.it
July 17, 2025 at 4:19 PM
This is so cool, congrats @lozanzi.bsky.social and team! Important implications for infection and IBD
Reposted by Manuela Raffatellu
We have decided to ban the use of GenAI for research, writing & creative work at our organization.
In fact, we make people sign an agreement saying that their research, analysis, writing, and creative work are *theirs* and not done by GenAI.
In fact, we make people sign an agreement saying that their research, analysis, writing, and creative work are *theirs* and not done by GenAI.
July 17, 2025 at 1:04 AM
We have decided to ban the use of GenAI for research, writing & creative work at our organization.
In fact, we make people sign an agreement saying that their research, analysis, writing, and creative work are *theirs* and not done by GenAI.
In fact, we make people sign an agreement saying that their research, analysis, writing, and creative work are *theirs* and not done by GenAI.
Happy that our manuscript showing that PgtE protease enables Salmonella to evade C3-mediated serum and neutrophil killing is published in mBio journals.asm.org/doi/10.1128/... - check out the companion paper from @rtsolis.bsky.social and team, focused on PgtE in the African Salmonella strain ST313
PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing | mBio
Non-typhoidal Salmonella serovars primarily cause gastrointestinal infections but can also lead to bacteremia
through mechanisms that are not completely elucidated. Here we show that the outer
membran...
journals.asm.org
July 15, 2025 at 6:57 PM
Happy that our manuscript showing that PgtE protease enables Salmonella to evade C3-mediated serum and neutrophil killing is published in mBio journals.asm.org/doi/10.1128/... - check out the companion paper from @rtsolis.bsky.social and team, focused on PgtE in the African Salmonella strain ST313
It was so nice to teach about Immunity to Bacterial Pathogens for the @aai.org Intro Course. I love to be part of this great training opportunity that AAI provides.
Dr. Manuela Raffatellu @manuelar.bsky.social concluded Part 1 of the Intro Course yesterday with an insightful lecture on the intricate interplay between bacterial pathogens and the host immune system! #AAICourses #ScienceEducation #Immunology
July 12, 2025 at 2:36 AM
It was so nice to teach about Immunity to Bacterial Pathogens for the @aai.org Intro Course. I love to be part of this great training opportunity that AAI provides.
Reposted by Manuela Raffatellu
The new open access policy of NIH will take effect next week (July 1st). All NIH funded research 🔬🧪🧬accepted after July 1st must be open access upon publication. Worried about fees? 💸 Check out how IAI stacks up against other journals—you might be surprised. #OpenAccess #SciComm #Microbiology
June 26, 2025 at 9:47 PM
The new open access policy of NIH will take effect next week (July 1st). All NIH funded research 🔬🧪🧬accepted after July 1st must be open access upon publication. Worried about fees? 💸 Check out how IAI stacks up against other journals—you might be surprised. #OpenAccess #SciComm #Microbiology
What do I love the most about UCSD? My amazing colleagues. Congratulations @chulab.bsky.social and @alistairrussell.bsky.social on your promotion and to Kees Murre for being elected to the NAS!
June 27, 2025 at 2:37 AM
What do I love the most about UCSD? My amazing colleagues. Congratulations @chulab.bsky.social and @alistairrussell.bsky.social on your promotion and to Kees Murre for being elected to the NAS!
Reposted by Manuela Raffatellu
So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!
As Robert Kuttner writes, the NIH will need support from Republican Senators to avoid draconian cuts to its FY2026 budget.
prospect.org/politics/202...
prospect.org/politics/202...
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
prospect.org
June 25, 2025 at 1:01 AM
So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!
Former and current member of the Raffatellu lab were well represented at #ASMicrobe in LA - it was great seeing everyone!
June 23, 2025 at 12:36 AM
Former and current member of the Raffatellu lab were well represented at #ASMicrobe in LA - it was great seeing everyone!
Check out the preview written by @romanagerner1.bsky.social on the excellent study from @mucosalimmunology.bsky.social about exploiting bacterial competition for rational design of mucosal vaccines
Honored to write a preview on Emma Slack’s latest work in Science: ‘Vaccine-enhanced competition permits rational bacterial strain replacement in the gut.’ A novel strategy to selectively replace microbial strains in the gut. Truly elegant science!
authors.elsevier.com/a/1lFMi6t8JE...
authors.elsevier.com/a/1lFMi6t8JE...
authors.elsevier.com
June 15, 2025 at 8:06 PM
Check out the preview written by @romanagerner1.bsky.social on the excellent study from @mucosalimmunology.bsky.social about exploiting bacterial competition for rational design of mucosal vaccines
Another amazing manuscript and resource led by @pieterdorrestein.bsky.social and team! So happy to be part of it, and to start using these new class of metabolites in the context of infection. Stay tuned!
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library
containing hundreds of N-acyl lipids, including conjugates with short-chain fatty
acids. This resource enabled the...
www.cell.com
June 12, 2025 at 11:51 PM
Another amazing manuscript and resource led by @pieterdorrestein.bsky.social and team! So happy to be part of it, and to start using these new class of metabolites in the context of infection. Stay tuned!
Reposted by Manuela Raffatellu
Science has more than doubled our life expectancy, revolutionized our quality of life, and powered unprecedented technological advancement. But can we afford to take scientific progress for granted? What happens when science funding is slashed, diversity is suppressed, and pseudoscience takes hold?
June 8, 2025 at 12:06 AM
Science has more than doubled our life expectancy, revolutionized our quality of life, and powered unprecedented technological advancement. But can we afford to take scientific progress for granted? What happens when science funding is slashed, diversity is suppressed, and pseudoscience takes hold?
Reposted by Manuela Raffatellu
Today, the ERC formally adopted a decision to increase its support for researchers moving to Europe.
On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe.
This extra funding is now x2 (up to €2 million!)
europa.eu/!6Vdgmp
On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe.
This extra funding is now x2 (up to €2 million!)
europa.eu/!6Vdgmp
May 16, 2025 at 10:58 AM
Today, the ERC formally adopted a decision to increase its support for researchers moving to Europe.
On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe.
This extra funding is now x2 (up to €2 million!)
europa.eu/!6Vdgmp
On top of its normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories / research teams in Europe.
This extra funding is now x2 (up to €2 million!)
europa.eu/!6Vdgmp
Reposted by Manuela Raffatellu
Excitement plus!! The full program is online for the upcoming GRC Salmonella Biology and Pathogenesis meeting. There is still some room in the schedule for short talks, which will be chosen from submitted abstracts. Submit your abstract, if you haven't done so already.
www.grc.org/salmonella-b...
www.grc.org/salmonella-b...
kermit the frog from the muppet show is standing in front of a red curtain .
ALT: kermit the frog from the muppet show is standing in front of a red curtain .
media.tenor.com
April 4, 2025 at 2:35 PM
Excitement plus!! The full program is online for the upcoming GRC Salmonella Biology and Pathogenesis meeting. There is still some room in the schedule for short talks, which will be chosen from submitted abstracts. Submit your abstract, if you haven't done so already.
www.grc.org/salmonella-b...
www.grc.org/salmonella-b...
Great opinion article in the @nytimes.com today: www.nytimes.com/2025/04/03/o...
Opinion | The Uncertain Fate of the Young American Scientist (Gift Article)
Young researchers are choosing between staying in science and staying in the United States.
www.nytimes.com
April 4, 2025 at 1:58 PM
Great opinion article in the @nytimes.com today: www.nytimes.com/2025/04/03/o...
Reposted by Manuela Raffatellu
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
elifesciences.org
April 2, 2025 at 1:02 PM
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
Reposted by Manuela Raffatellu
I have been teaching classes on the gut #microbiome for almost 20 years and always struggled to have a good book to recommend. Finally there is one. Fergus Shanahan's "Fast Facts: The Gut Microbiome" provides expert insight, is brilliant, and it is free.
doi.org/10.1159/isbn...
doi.org/10.1159/isbn...
Fast Facts: The Gut Microbiome
‘Fast Facts: The Gut Microbiome’, though pithy and concise, is amazingly comprehensive and takes the reader through all major aspects of the human gut micr
doi.org
March 24, 2025 at 4:30 PM
I have been teaching classes on the gut #microbiome for almost 20 years and always struggled to have a good book to recommend. Finally there is one. Fergus Shanahan's "Fast Facts: The Gut Microbiome" provides expert insight, is brilliant, and it is free.
doi.org/10.1159/isbn...
doi.org/10.1159/isbn...
Reposted by Manuela Raffatellu
Exciting #PhD project where you will learn how to study #Host-pathogen interactions including #infection models, cell biology, microbiology, molecular biology and bioinformatics - you will address questions important to global health including #typhoid fever and invasive NTS disease #iNTS pls share
🎓 #PhDPosition !
🔍 Mechanisms of infection and virulence of Salmonella in the liver with Dr Naiara Beraza and Dr Rob Kingsley @drrobkingsley.bsky.social
➡️ buff.ly/4Md1y29
🔍 Mechanisms of infection and virulence of Salmonella in the liver with Dr Naiara Beraza and Dr Rob Kingsley @drrobkingsley.bsky.social
➡️ buff.ly/4Md1y29
March 20, 2025 at 6:44 PM
Exciting #PhD project where you will learn how to study #Host-pathogen interactions including #infection models, cell biology, microbiology, molecular biology and bioinformatics - you will address questions important to global health including #typhoid fever and invasive NTS disease #iNTS pls share
Reposted by Manuela Raffatellu
University of California announced a systemwide hiring freeze. This affects not 1 but 10 campuses (including UCLA, UC Berkeley, UC San Francisco, UC San Diego among others) plus 3 national labs with impact on medical and scientific research and local economies.
www.reuters.com/world/us/uni...
www.reuters.com/world/us/uni...
University of California sets hiring freeze in anticipation of Trump cuts
The University of California has imposed a system-wide hiring freeze and made additional cuts, its president said on Wednesday, as part of efforts to try to mitigate the impact of sharp cuts in federal funding.
www.reuters.com
March 19, 2025 at 10:13 PM
University of California announced a systemwide hiring freeze. This affects not 1 but 10 campuses (including UCLA, UC Berkeley, UC San Francisco, UC San Diego among others) plus 3 national labs with impact on medical and scientific research and local economies.
www.reuters.com/world/us/uni...
www.reuters.com/world/us/uni...
Reposted by Manuela Raffatellu
With everything happening in the US right now, how safe are scientific conferences for foreign participants in the US? I think this is something we have to discuss as a scientific community. I am hesitating to register for US meetings due to the unpredictable situation. Others who feel the same?
March 19, 2025 at 8:03 AM
With everything happening in the US right now, how safe are scientific conferences for foreign participants in the US? I think this is something we have to discuss as a scientific community. I am hesitating to register for US meetings due to the unpredictable situation. Others who feel the same?