@mansoor-steven.bsky.social
Pinned
Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket.
www.pnas.org/doi/10.1073/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
www.pnas.org/doi/10.1073/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.
Reposted
Reposted
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoem
September 16, 2025 at 11:29 AM
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoem
Reposted
Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
September 15, 2025 at 6:11 PM
Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.
Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket.
www.pnas.org/doi/10.1073/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
www.pnas.org/doi/10.1073/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
September 14, 2025 at 3:55 AM
A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.
A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.
Subtype-specific structural features of the hearing loss-associated human P2X2 receptor pubmed.ncbi.nlm.nih.gov/40938707/ #cryoem
September 14, 2025 at 3:55 AM
A fantastic collaboration with Dr. Christa Müller from the University of Bonn. Congratulations to graduate students Franka Westermann and Adam Oken for their efforts on this manuscript.
Reposted
@volluminstitute.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! Read the full article: bit.ly/4b9gOw9
August 15, 2025 at 8:16 PM
@volluminstitute.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! Read the full article: bit.ly/4b9gOw9
Reposted
@ohsunews.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! news.ohsu.edu/2025/06/23/o...
August 13, 2025 at 8:27 PM
@ohsunews.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! news.ohsu.edu/2025/06/23/o...
The KCVI research retreat was a great success this year.
Very happy to participate. Looking forward to making this an annual event!
Very happy to participate. Looking forward to making this an annual event!
A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM
April 26, 2025 at 12:55 AM
The KCVI research retreat was a great success this year.
Very happy to participate. Looking forward to making this an annual event!
Very happy to participate. Looking forward to making this an annual event!
Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing.
If you are interested, please watch a recording of his seminar, linked here:
youtu.be/IdcoLJc7X8M
If you are interested, please watch a recording of his seminar, linked here:
youtu.be/IdcoLJc7X8M
March 27, 2025: Adam Oken, Oregon Health and Sciences University
YouTube video by CryoEM Service Centers
youtu.be
March 30, 2025 at 6:15 PM
Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing.
If you are interested, please watch a recording of his seminar, linked here:
youtu.be/IdcoLJc7X8M
If you are interested, please watch a recording of his seminar, linked here:
youtu.be/IdcoLJc7X8M
Reposted
Navigating the worlds of research and patient care requires both precision and passion, and @ohsunews.bsky.social's Dr. Steven E. Mansoor finds fulfillment in this work as a physician-scientist. ohsufoundation.org/stories/the-...
The Changemakers: Steven E. Mansoor, M.D., Ph.D. | OHSU Foundation
Cardiologist and physician-scientist Steven Mansoor, M.D., Ph.D., is researching new drugs to fight a variety of medical conditions.
ohsufoundation.org
March 10, 2025 at 5:01 PM
Navigating the worlds of research and patient care requires both precision and passion, and @ohsunews.bsky.social's Dr. Steven E. Mansoor finds fulfillment in this work as a physician-scientist. ohsufoundation.org/stories/the-...
A paper from our group published a couple of months ago.
Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket. @ScienceAdvence. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bqh
www.science.org
March 2, 2025 at 9:16 AM
A paper from our group published a couple of months ago.
I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.
UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design www.biorxiv.org/content/10.1101/2025.02.12.637899v1 #cryoem
February 26, 2025 at 3:52 AM
I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.