MANIFEST IO
@manifest-cirrp.bsky.social
UK-wide cancer immunotherapy response research platform | MANIFEST: Multiomic ANalysis of Immunotherapy Features Evidencing Success & Toxicity
🔗 https://www.manifest-io.org.uk
🔗 https://www.manifest-io.org.uk
Pinned
MANIFEST IO
@manifest-cirrp.bsky.social
· Dec 18
🦋 MANIFEST is excited to join the @bsky.app community!
🧑🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more
🤝 Together, we can advance cancer care for patients
🧑🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more
🤝 Together, we can advance cancer care for patients
Reposted by MANIFEST IO
Want to know more about #MANIFESTuk?
To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery.
Check it out.
@manifest-cirrp.bsky.social
To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery.
Check it out.
@manifest-cirrp.bsky.social
May 12, 2025 at 9:26 PM
Want to know more about #MANIFESTuk?
To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery.
Check it out.
@manifest-cirrp.bsky.social
To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery.
Check it out.
@manifest-cirrp.bsky.social
Reposted by MANIFEST IO
🚀 We finally had our first in-person #MANIFESTuk consortium meeting @crick.ac.uk today.
So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST.
Let’s keep going! 🙌
@manifest-cirrp.bsky.social
So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST.
Let’s keep going! 🙌
@manifest-cirrp.bsky.social
May 12, 2025 at 9:13 PM
🚀 We finally had our first in-person #MANIFESTuk consortium meeting @crick.ac.uk today.
So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST.
Let’s keep going! 🙌
@manifest-cirrp.bsky.social
So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST.
Let’s keep going! 🙌
@manifest-cirrp.bsky.social
Our keynote speaker Elana Fertig (@univofmaryland.bsky.social) presenting some fantastic work on “Modelling the TME of clinical trials with virtual cells” 🦠🖥️
May 12, 2025 at 3:16 PM
Our keynote speaker Elana Fertig (@univofmaryland.bsky.social) presenting some fantastic work on “Modelling the TME of clinical trials with virtual cells” 🦠🖥️
Ajitha Rajan (@edinburgh-uni.bsky.social) joins us over the web to present on “Multimodal Data Integration” 🔬
May 12, 2025 at 2:23 PM
Ajitha Rajan (@edinburgh-uni.bsky.social) joins us over the web to present on “Multimodal Data Integration” 🔬
Up next, Santiago Zelenay (@cruk-mi.bsky.social) presents his work on setting up a “Patient Derived Tumour Fragment platform” 🧫
May 12, 2025 at 1:42 PM
Up next, Santiago Zelenay (@cruk-mi.bsky.social) presents his work on setting up a “Patient Derived Tumour Fragment platform” 🧫
Anne-Laure Cattin (@crick.ac.uk) starts the third session presenting some amazing work on “Deconvoluting the in situ tumour immune microenvironment” 🧫🔬
May 12, 2025 at 1:24 PM
Anne-Laure Cattin (@crick.ac.uk) starts the third session presenting some amazing work on “Deconvoluting the in situ tumour immune microenvironment” 🧫🔬
Up next Dominic Rothwell (@cruknbc.bsky.social) presents “cfDNA methylation profiling as a precision medicine biomarker in cancer” 🧬🔍
May 12, 2025 at 11:38 AM
Up next Dominic Rothwell (@cruknbc.bsky.social) presents “cfDNA methylation profiling as a precision medicine biomarker in cancer” 🧬🔍
James Jones (@cruk-ci.bsky.social) presents amazing work on “Cytokine profiling in kidney cancer translational studies” 🏥
May 12, 2025 at 11:29 AM
James Jones (@cruk-ci.bsky.social) presents amazing work on “Cytokine profiling in kidney cancer translational studies” 🏥
@maxemmerichderm.bsky.social (@crick.ac.uk) kicks off the second session presenting “Comprehensive blood profiling to derive immune signatures predictive of checkpoint inhibitor response and toxicity”. 🩸☢️
May 12, 2025 at 11:14 AM
@maxemmerichderm.bsky.social (@crick.ac.uk) kicks off the second session presenting “Comprehensive blood profiling to derive immune signatures predictive of checkpoint inhibitor response and toxicity”. 🩸☢️
Reposted by MANIFEST IO
🎯 Delighted that the May 2025 issue of Cancer Discovery @theaacr.bsky.social features #MANIFESTuk!
Check out this ‘In Focus’ piece summarising our vision and ambitions for #CancerImmunotherapy 👇
aacrjournals.org/cancerdiscov...
@manifest-cirrp.bsky.social
Check out this ‘In Focus’ piece summarising our vision and ambitions for #CancerImmunotherapy 👇
aacrjournals.org/cancerdiscov...
@manifest-cirrp.bsky.social
May 8, 2025 at 8:50 PM
🎯 Delighted that the May 2025 issue of Cancer Discovery @theaacr.bsky.social features #MANIFESTuk!
Check out this ‘In Focus’ piece summarising our vision and ambitions for #CancerImmunotherapy 👇
aacrjournals.org/cancerdiscov...
@manifest-cirrp.bsky.social
Check out this ‘In Focus’ piece summarising our vision and ambitions for #CancerImmunotherapy 👇
aacrjournals.org/cancerdiscov...
@manifest-cirrp.bsky.social
Reposted by MANIFEST IO
💡Inspiring to be in amongst esteemed colleagues at BSI Cancer Immunotherapies Summit today at The Royal Society.
Happy to share our vision & ambitions for #MANIFESTuk + how we can work collaboratively to tackle some of the biggest questions in immuno-oncology.
@manifest-cirrp.bsky.social
Happy to share our vision & ambitions for #MANIFESTuk + how we can work collaboratively to tackle some of the biggest questions in immuno-oncology.
@manifest-cirrp.bsky.social
April 14, 2025 at 8:34 PM
💡Inspiring to be in amongst esteemed colleagues at BSI Cancer Immunotherapies Summit today at The Royal Society.
Happy to share our vision & ambitions for #MANIFESTuk + how we can work collaboratively to tackle some of the biggest questions in immuno-oncology.
@manifest-cirrp.bsky.social
Happy to share our vision & ambitions for #MANIFESTuk + how we can work collaboratively to tackle some of the biggest questions in immuno-oncology.
@manifest-cirrp.bsky.social
🚨Opportunity to join the MANIFEST team ‼️
We’re looking for:
💻 A Talented ML Engineer
To:
➡️ Join a team of computational biologists
💊Deliver on integrated immune-oncology biomarker signatures
📍@crick.ac.uk @TurajlicLab
🧑💻manifest-io.org.uk
Link 👇:
crick.wd3.myworkdayjobs.com/External/job/L…
We’re looking for:
💻 A Talented ML Engineer
To:
➡️ Join a team of computational biologists
💊Deliver on integrated immune-oncology biomarker signatures
📍@crick.ac.uk @TurajlicLab
🧑💻manifest-io.org.uk
Link 👇:
crick.wd3.myworkdayjobs.com/External/job/L…
https://crick.wd3.myworkdayjobs.com/External/job/L…
March 30, 2025 at 8:15 PM
🚨Opportunity to join the MANIFEST team ‼️
We’re looking for:
💻 A Talented ML Engineer
To:
➡️ Join a team of computational biologists
💊Deliver on integrated immune-oncology biomarker signatures
📍@crick.ac.uk @TurajlicLab
🧑💻manifest-io.org.uk
Link 👇:
crick.wd3.myworkdayjobs.com/External/job/L…
We’re looking for:
💻 A Talented ML Engineer
To:
➡️ Join a team of computational biologists
💊Deliver on integrated immune-oncology biomarker signatures
📍@crick.ac.uk @TurajlicLab
🧑💻manifest-io.org.uk
Link 👇:
crick.wd3.myworkdayjobs.com/External/job/L…
Fantastic to see @manifest-cirrp.bsky.social represented at Manchester Immuno-Oncology Network (MION) Spring Event.
🏥 🧬 Criticial work will be led by colleagues & co-investigators:
🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie
🏥 🧬 Criticial work will be led by colleagues & co-investigators:
🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie
Great to see such a great turnout at our Manchester Immuno-Oncology Network (MION) 🐝 Spring event.
6️⃣ months in: Finally feel like I have arrived - presented my PhD work & also showcased @manifest-cirrp.bsky.social.
@mcrcnews.bsky.social
@giampazolias.bsky.social
@santiagozelenay.bsky.social
6️⃣ months in: Finally feel like I have arrived - presented my PhD work & also showcased @manifest-cirrp.bsky.social.
@mcrcnews.bsky.social
@giampazolias.bsky.social
@santiagozelenay.bsky.social
March 25, 2025 at 8:46 PM
Fantastic to see @manifest-cirrp.bsky.social represented at Manchester Immuno-Oncology Network (MION) Spring Event.
🏥 🧬 Criticial work will be led by colleagues & co-investigators:
🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie
🏥 🧬 Criticial work will be led by colleagues & co-investigators:
🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie
Reposted by MANIFEST IO
🚀 First set of results since launch of #MANIFESTuk - our wide-utility multiomic platform for cancer immunotherapy.
Congratulations to our very own @maxemmerichderm.bsky.social for the oral presentation at the inaugural #AACRIO25 Congress - HD-immunoprofiling from blood 🩸.
Check it out 👇
Congratulations to our very own @maxemmerichderm.bsky.social for the oral presentation at the inaugural #AACRIO25 Congress - HD-immunoprofiling from blood 🩸.
Check it out 👇
February 27, 2025 at 10:44 PM
🚀 First set of results since launch of #MANIFESTuk - our wide-utility multiomic platform for cancer immunotherapy.
Congratulations to our very own @maxemmerichderm.bsky.social for the oral presentation at the inaugural #AACRIO25 Congress - HD-immunoprofiling from blood 🩸.
Check it out 👇
Congratulations to our very own @maxemmerichderm.bsky.social for the oral presentation at the inaugural #AACRIO25 Congress - HD-immunoprofiling from blood 🩸.
Check it out 👇
🚨First output from the MANIFEST platform‼️
🩸PBMC derived immune signatures can predict ICI response & tox!
🧑💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences
📍Watch this space for multimodal composite biomarkers
🩸PBMC derived immune signatures can predict ICI response & tox!
🧑💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences
📍Watch this space for multimodal composite biomarkers
February 26, 2025 at 9:19 PM
🚨First output from the MANIFEST platform‼️
🩸PBMC derived immune signatures can predict ICI response & tox!
🧑💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences
📍Watch this space for multimodal composite biomarkers
🩸PBMC derived immune signatures can predict ICI response & tox!
🧑💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences
📍Watch this space for multimodal composite biomarkers
Opportunity to reflect on the challenges of biomarker discovery in RCC‼️#GU25
Need for:
📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts
➡️ Generation of multimodal biomarker signatures
🧑💻: manifest-io.org.uk
Need for:
📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts
➡️ Generation of multimodal biomarker signatures
🧑💻: manifest-io.org.uk
February 16, 2025 at 5:17 PM
Opportunity to reflect on the challenges of biomarker discovery in RCC‼️#GU25
Need for:
📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts
➡️ Generation of multimodal biomarker signatures
🧑💻: manifest-io.org.uk
Need for:
📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts
➡️ Generation of multimodal biomarker signatures
🧑💻: manifest-io.org.uk
Fantastic to see integrated translational analyses presented on the podium at #GU25 🧬🔬
Elegantly presented by Prof Albiges
🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies
👇🏾
🧑💻manifest-io.org.uk
Elegantly presented by Prof Albiges
🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies
👇🏾
🧑💻manifest-io.org.uk
🚨🧬A translational start to D3 #GU25 🧬🚨
Final Survival Analysis: COSMIC-313
💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo
❌ Nil OS Benefit
‼️ Triplet limited by Tox:
⬇️ ICI # No & Dose
🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!
Final Survival Analysis: COSMIC-313
💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo
❌ Nil OS Benefit
‼️ Triplet limited by Tox:
⬇️ ICI # No & Dose
🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!
February 15, 2025 at 5:09 PM
Fantastic to see integrated translational analyses presented on the podium at #GU25 🧬🔬
Elegantly presented by Prof Albiges
🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies
👇🏾
🧑💻manifest-io.org.uk
Elegantly presented by Prof Albiges
🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies
👇🏾
🧑💻manifest-io.org.uk
🔦 Spotlight on ctDNA as Biomarker in Bladder Ca.
🔴 Emerging role as a surrogate for path response & survival ‼️
Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑💻 Combinatorial Biomarkers
📊 Data Harmonisation
#GU25
🔴 Emerging role as a surrogate for path response & survival ‼️
Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑💻 Combinatorial Biomarkers
📊 Data Harmonisation
#GU25
February 14, 2025 at 11:48 PM
🔦 Spotlight on ctDNA as Biomarker in Bladder Ca.
🔴 Emerging role as a surrogate for path response & survival ‼️
Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑💻 Combinatorial Biomarkers
📊 Data Harmonisation
#GU25
🔴 Emerging role as a surrogate for path response & survival ‼️
Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑💻 Combinatorial Biomarkers
📊 Data Harmonisation
#GU25
Reposted by MANIFEST IO
🚨Follow @manifest-cirrp.bsky.social
🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca
🧑🏾💻 manifest-io.org.uk
#GU25
🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca
🧑🏾💻 manifest-io.org.uk
#GU25
Fantastic discussant session from @erplimackmd.bsky.social this morning at #GU25
🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA
🧬 Biomarker need to optimise stratification and minimise risk of over-treatment
➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)
🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA
🧬 Biomarker need to optimise stratification and minimise risk of over-treatment
➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)
February 14, 2025 at 5:13 PM
🚨Follow @manifest-cirrp.bsky.social
🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca
🧑🏾💻 manifest-io.org.uk
#GU25
🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca
🧑🏾💻 manifest-io.org.uk
#GU25
Excited to contribute to this space‼️
Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠
Great to see members of the consortium together at #Immuno25
Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠
Great to see members of the consortium together at #Immuno25
This morning, we heard all about biomarkers in cancer immunotherapy 🧬🔬🧪👨⚕️. #Immuno25
A comprehensive overview from the amazing @zaydtippu.bsky.social, who managed to package a complex field into 20mins 🙌.
Excited to see how @manifest-cirrp.bsky.social will hopefully contribute going forwards!
A comprehensive overview from the amazing @zaydtippu.bsky.social, who managed to package a complex field into 20mins 🙌.
Excited to see how @manifest-cirrp.bsky.social will hopefully contribute going forwards!
February 3, 2025 at 12:14 AM
Excited to contribute to this space‼️
Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠
Great to see members of the consortium together at #Immuno25
Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠
Great to see members of the consortium together at #Immuno25
🌟 More exciting opportunities to join the @manifest-cirrp.bsky.social consortium at @crick.ac.uk!
We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑🔬 Senior Laboratory Research Scientist (Flow Cytometry)
Apply now 👉 www.crick.ac.uk/careers-and-...
We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑🔬 Senior Laboratory Research Scientist (Flow Cytometry)
Apply now 👉 www.crick.ac.uk/careers-and-...
December 27, 2024 at 5:01 PM
🌟 More exciting opportunities to join the @manifest-cirrp.bsky.social consortium at @crick.ac.uk!
We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑🔬 Senior Laboratory Research Scientist (Flow Cytometry)
Apply now 👉 www.crick.ac.uk/careers-and-...
We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑🔬 Senior Laboratory Research Scientist (Flow Cytometry)
Apply now 👉 www.crick.ac.uk/careers-and-...
📢 New job opportunities open in computational modelling, genomics and imaging for Postdoctoral and Senior Scientists based @crick.ac.uk!
🧑🔬 Become part of MANIFEST, a UK-wide consortium of 14 academic institutions, 6 NHS trusts and several industry partners all tackling challenges in #immunotherapy
🧑🔬 Become part of MANIFEST, a UK-wide consortium of 14 academic institutions, 6 NHS trusts and several industry partners all tackling challenges in #immunotherapy
December 19, 2024 at 12:32 PM
📢 New job opportunities open in computational modelling, genomics and imaging for Postdoctoral and Senior Scientists based @crick.ac.uk!
🧑🔬 Become part of MANIFEST, a UK-wide consortium of 14 academic institutions, 6 NHS trusts and several industry partners all tackling challenges in #immunotherapy
🧑🔬 Become part of MANIFEST, a UK-wide consortium of 14 academic institutions, 6 NHS trusts and several industry partners all tackling challenges in #immunotherapy
🦋 MANIFEST is excited to join the @bsky.app community!
🧑🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more
🤝 Together, we can advance cancer care for patients
🧑🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more
🤝 Together, we can advance cancer care for patients
December 18, 2024 at 4:58 PM
🦋 MANIFEST is excited to join the @bsky.app community!
🧑🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more
🤝 Together, we can advance cancer care for patients
🧑🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more
🤝 Together, we can advance cancer care for patients