Devika S Manickam
@manickam-lab.bsky.social
Drug and mitochondria delivery to the BBB using nanoparticles and large extracellular vesicles. Mom, Assoc. Prof., South Indian classical vocalist (student). Follow our work and other news: https://research.duq.edu/manickamlab/index.html
Reposted by Devika S Manickam
What's $40k+ a year in unexpected publishing costs in these turbulent times! 😆😭
June 17, 2025 at 6:44 PM
What's $40k+ a year in unexpected publishing costs in these turbulent times! 😆😭
Super-grateful to @NIH_NINDS, our awesome team and wonderful collaborators! 🙏🏽🙏🏽 @SrutiShiva @LD_McCullough #Venu Venna @UTHealthHouston Looking forward to further refining the engineering of mitochondria-enriched EVs!
June 12, 2025 at 10:39 PM
Super-grateful to @NIH_NINDS, our awesome team and wonderful collaborators! 🙏🏽🙏🏽 @SrutiShiva @LD_McCullough #Venu Venna @UTHealthHouston Looking forward to further refining the engineering of mitochondria-enriched EVs!
This is a fantastic manuscript! Hope all goes well with the review :) Thank you @blacoste.bsky.social for collaborating with us!
Happy to share the current version of our latest story, currently under peer review. Cool collab with @dablab.bsky.social @manickam-lab.bsky.social and others. We are not only understanding endothelial deficits in an #autism model, but now also capable of rescuing them! #16p11.2 #treatment #P2Y2
Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...
www.biorxiv.org
June 3, 2025 at 10:41 PM
This is a fantastic manuscript! Hope all goes well with the review :) Thank you @blacoste.bsky.social for collaborating with us!
Reposted by Devika S Manickam
Happy to share the current version of our latest story, currently under peer review. Cool collab with @dablab.bsky.social @manickam-lab.bsky.social and others. We are not only understanding endothelial deficits in an #autism model, but now also capable of rescuing them! #16p11.2 #treatment #P2Y2
Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...
www.biorxiv.org
June 3, 2025 at 8:33 AM
Happy to share the current version of our latest story, currently under peer review. Cool collab with @dablab.bsky.social @manickam-lab.bsky.social and others. We are not only understanding endothelial deficits in an #autism model, but now also capable of rescuing them! #16p11.2 #treatment #P2Y2
Reposted by Devika S Manickam
🚨 I’m hiring a postdoc for Fall 2025 with experience in microbial ‘omics data analysis and phylogenetics/genomics. Projects will be centered around ancient microbial ecology & evolution. Click here for more information: bpb-us-e1.wpmucdn.com/wp.txstate.e...
Please share, thank you 🙏🏻
Please share, thank you 🙏🏻
May 28, 2025 at 3:17 PM
🚨 I’m hiring a postdoc for Fall 2025 with experience in microbial ‘omics data analysis and phylogenetics/genomics. Projects will be centered around ancient microbial ecology & evolution. Click here for more information: bpb-us-e1.wpmucdn.com/wp.txstate.e...
Please share, thank you 🙏🏻
Please share, thank you 🙏🏻
Reposted by Devika S Manickam
50d free: authors.elsevier.com/a/1l8cjcI2-9...
Congrats Luis on your 1st author paper!
We identified a potent mast cell-activating peptide (MP12W) that, when combined with CpG, forms a nanoparticle intranasal vaccine providing broad protection against H1 influenza.
@dpmp-unc.bsky.social
Congrats Luis on your 1st author paper!
We identified a potent mast cell-activating peptide (MP12W) that, when combined with CpG, forms a nanoparticle intranasal vaccine providing broad protection against H1 influenza.
@dpmp-unc.bsky.social
May 23, 2025 at 11:06 AM
50d free: authors.elsevier.com/a/1l8cjcI2-9...
Congrats Luis on your 1st author paper!
We identified a potent mast cell-activating peptide (MP12W) that, when combined with CpG, forms a nanoparticle intranasal vaccine providing broad protection against H1 influenza.
@dpmp-unc.bsky.social
Congrats Luis on your 1st author paper!
We identified a potent mast cell-activating peptide (MP12W) that, when combined with CpG, forms a nanoparticle intranasal vaccine providing broad protection against H1 influenza.
@dpmp-unc.bsky.social
Reposted by Devika S Manickam
Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.
Background Alzheimer's disease (AD), the most common neurodegenerative condition, is characterized by significant cognitive decline. To detect these changes, diagnostic imaging approaches rely primari...
www.biorxiv.org
May 14, 2025 at 5:18 PM
Neuro-Metabolic and Vascular Dysfunction as an Early Diagnostic for Alzheimer's Disease and Related Dementias.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Devika S Manickam
We were awarded a TrailBlazer R21 from NIBIB to design chaperone-mimetic polymers for ribonucleoprotein delivery. Excited to work with coIs Gerard Madlambayan and Serveh Kamrava.
April 16, 2025 at 1:30 PM
We were awarded a TrailBlazer R21 from NIBIB to design chaperone-mimetic polymers for ribonucleoprotein delivery. Excited to work with coIs Gerard Madlambayan and Serveh Kamrava.
Reposted by Devika S Manickam
Meme of the week!
April 25, 2025 at 7:35 PM
Meme of the week!
Reposted by Devika S Manickam
WashU is accepting applications for Postdoctoral Fellowship in Diabetes & Related Metabolic Diseases (T32 DK007120). If you are eligible for T32 support (need to be a US citizen or permanent resident) and are interested in working with stem cell-derived islets, please contact me!
April 22, 2025 at 2:19 PM
WashU is accepting applications for Postdoctoral Fellowship in Diabetes & Related Metabolic Diseases (T32 DK007120). If you are eligible for T32 support (need to be a US citizen or permanent resident) and are interested in working with stem cell-derived islets, please contact me!
Happy to share our new preprint on ionic liquid coated LNPs! Purva Khare led this work in collaboration with Christine Hamadani, PhD Sara Edgecomb and Eden E. L. Tanner
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Ionic liquid-coated lipid nanoparticles promote enhanced red blood cell hitchhiking
Lipid nanoparticles (LNPs) have transformed the delivery of nucleic acid therapeutics; however, their natural tropism favors the liver resulting in clearance by the reticuloendothelial system, with le...
www.biorxiv.org
April 22, 2025 at 1:51 PM
Happy to share our new preprint on ionic liquid coated LNPs! Purva Khare led this work in collaboration with Christine Hamadani, PhD Sara Edgecomb and Eden E. L. Tanner
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Devika S Manickam
@Glaivy Batsuli (Stanford) & I are track chairs for the Basic Science (& possibly translational/laboratory) sessions for @THSNA 2026 www.thsna.org/web/
Know trainees or under-represented voices (including yourself!) we should consider?
#thsna2026 #thrombosis #hemostasis
DM or comment below!🙏
Know trainees or under-represented voices (including yourself!) we should consider?
#thsna2026 #thrombosis #hemostasis
DM or comment below!🙏
a cartoon of a penguin wearing a red hat and holding a megaphone
ALT: a cartoon of a penguin wearing a red hat and holding a megaphone
media.tenor.com
April 10, 2025 at 11:36 PM
@Glaivy Batsuli (Stanford) & I are track chairs for the Basic Science (& possibly translational/laboratory) sessions for @THSNA 2026 www.thsna.org/web/
Know trainees or under-represented voices (including yourself!) we should consider?
#thsna2026 #thrombosis #hemostasis
DM or comment below!🙏
Know trainees or under-represented voices (including yourself!) we should consider?
#thsna2026 #thrombosis #hemostasis
DM or comment below!🙏
Reposted by Devika S Manickam
Reposted by Devika S Manickam
We shouldn’t ask kids what they want to be when they grow up. It encourages them to define themselves in terms of work.
Who we become is not a question of career—it’s a matter of character.
The highest aspiration is to be a person of generosity, integrity, humility, curiosity, and wisdom.
Who we become is not a question of career—it’s a matter of character.
The highest aspiration is to be a person of generosity, integrity, humility, curiosity, and wisdom.
April 8, 2025 at 4:05 PM
We shouldn’t ask kids what they want to be when they grow up. It encourages them to define themselves in terms of work.
Who we become is not a question of career—it’s a matter of character.
The highest aspiration is to be a person of generosity, integrity, humility, curiosity, and wisdom.
Who we become is not a question of career—it’s a matter of character.
The highest aspiration is to be a person of generosity, integrity, humility, curiosity, and wisdom.
Reposted by Devika S Manickam
This week's meme of the week!
April 8, 2025 at 5:26 PM
This week's meme of the week!
Reposted by Devika S Manickam
This week's meme of the week! #sciencememe
April 4, 2025 at 5:40 PM
This week's meme of the week! #sciencememe
Reposted by Devika S Manickam
Sign the petition! Canadians: An Open Letter to Canadians: Let's Ensure Canada's Research Reflects All Canadians
An Open Letter to Canadians: Let's Ensure Canada's Research Reflects All Canadians
🚨 Canada needs research that works for everyone! 🚨
Science shapes the policies that impact our daily lives—from healthcare to climate action to economic growth. But if our research doesn’t include di...
actionnetwork.org
April 4, 2025 at 6:13 PM
Sign the petition! Canadians: An Open Letter to Canadians: Let's Ensure Canada's Research Reflects All Canadians
Reposted by Devika S Manickam
Who would've thought you could play Bingo with posters? Introducing #PosterBingo for the Controlled Release Society Annual Meeting! Inspired by an idea #AssafZinger and his students had!
See you in Philly!
youtu.be/xMpxLsW-2QA?...
See you in Philly!
youtu.be/xMpxLsW-2QA?...
CRS 2025 Annual Meeting & Exposition: Meet Our Director of Abstract Judging, Juliane Nguyen, PhD!
YouTube video by Controlled Release Society CRS
youtu.be
April 4, 2025 at 1:34 AM
Who would've thought you could play Bingo with posters? Introducing #PosterBingo for the Controlled Release Society Annual Meeting! Inspired by an idea #AssafZinger and his students had!
See you in Philly!
youtu.be/xMpxLsW-2QA?...
See you in Philly!
youtu.be/xMpxLsW-2QA?...
Reposted by Devika S Manickam
New publication out in Digestive Diseases and Sciences in collaboration with @julienguyenlab.bsky.social
“Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice”
🔗 link.springer.com/article/10.1...
“Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice”
🔗 link.springer.com/article/10.1...
April 3, 2025 at 8:54 PM
New publication out in Digestive Diseases and Sciences in collaboration with @julienguyenlab.bsky.social
“Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice”
🔗 link.springer.com/article/10.1...
“Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice”
🔗 link.springer.com/article/10.1...
Reposted by Devika S Manickam
A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social !
uknow.uky.edu/research/fue...
uknow.uky.edu/research/fue...
Fueling sleep: UK researchers show key metabolic link to restful nights
Scientists have long recognized the brain’s need for energy, but groundbreaking research from the University of Kentucky’s Sanders-Brown Center on Aging has now illuminated how the brain’s energy uti...
uknow.uky.edu
March 27, 2025 at 2:02 PM
A great write up on our recent work in PNAS attempting to understand metabolic drivers of sleep, led by @ncons95.bsky.social !
uknow.uky.edu/research/fue...
uknow.uky.edu/research/fue...
Reposted by Devika S Manickam
Important diabetes news. Unfortunately, while VX264 (Vertex's encapsulated stem cell derived islet product) has been safe in patients, the company has discontinued the trial due to insufficient function of the cells. investors.vrtx.com/news-release...
Vertex Announces Program Updates for Type 1 Diabetes Portfolio | Vertex Pharmaceuticals
The Investor Relations website contains information about Vertex Pharmaceuticals's business for stockholders, potential investors, and financial analysts.
investors.vrtx.com
April 2, 2025 at 1:50 PM
Important diabetes news. Unfortunately, while VX264 (Vertex's encapsulated stem cell derived islet product) has been safe in patients, the company has discontinued the trial due to insufficient function of the cells. investors.vrtx.com/news-release...
Official now! Congratulations to Dr. Purva Khare on a stellar defense earlier today! We are very proud of you and will keep rooting for your continued successes at Merck!
April 1, 2025 at 12:20 AM
Official now! Congratulations to Dr. Purva Khare on a stellar defense earlier today! We are very proud of you and will keep rooting for your continued successes at Merck!
Reposted by Devika S Manickam
One more for the Science 🧪 feed!
Getting therapeutic peptides into the brain is a huge challenge. What if bacteria in your nasal epithelium could synthesize these drugs and deliver them directly and continuously to your brain, bypassing the BBB?
Beautiful proof of concept in a new study:
www.cell.com/cell/pdf/S00...
#longevity
Beautiful proof of concept in a new study:
www.cell.com/cell/pdf/S00...
#longevity
March 31, 2025 at 11:09 AM
One more for the Science 🧪 feed!