What happens after a few drinks at the airport lounge?

Very cool!!

Your plane runs on Windows 2000

Thanks for all your hard work @haleyv.bsky.social !!

Many thanks to collaborators @haleyv.bsky.social and the Marie-Ève Tremblay lab for their amazing commitment and collaboration on the electron microscopy. Also many thanks to the rest of the authors for their contribs!

Overall we see subtle developmental and neurodevelopmental variation that require far more examination about their functional consequences. But we believe that his provides and excellent lifespan baseline for the impact of prenatal #THC exposure

during gestation, when examining the hippocampi using electron microscopy we observed a high number of dividing cells

Behaviourally we observed:

1) females showed more characteristics of distress with fewer long calls and more calls overall
2) females showed difference in total distance moved and time spent in the center of the open field

Mouse brain development showed:

1) Larger ventricles during the gestational period.
2)Show decelerated brain growth in early life
3) Females show lower brain volumes and growth in key regions like thalamus and amygdala

Mice were

1) smaller during gestation
2) underwent accelerated growth (as indexed by weight) after they are born
2) female mice stay underweight once they reach adulthood and male mice catch up

We examine three cohorts of mice:

1) At late fetal stages
2) Early on in post-natal development
3) After weaning all the until post-natal day 90

We used a combination of maternal observations, stage appropriate behaviours, and longitudinal MRI postnatally

7. I thank all study participants and the team! @bogglerapture.bsky.social, @konradwagstyl.bsky.social, @mallarchak.bsky.social, @coevolvinglab.bsky.social + others not on BlueSky. Preprint: doi.org/10.1101/2025.09.10.675377

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