Marcos Castro e Silva, PhD 🇧🇷
@macscastro.bsky.social
Postdoc fellow at @IBE_Barcelona @UPFBarcelona • Interested in how genomics can help us understand human history and evolution • he/him
Thank you @albanietoh.bsky.social and @xavimartiperez.bsky.social for putting the effort to organizing this workshop! 🙏
June 17, 2025 at 9:28 AM
Thank you @albanietoh.bsky.social and @xavimartiperez.bsky.social for putting the effort to organizing this workshop! 🙏
Obrigado Nikolas!
May 17, 2025 at 1:57 PM
Obrigado Nikolas!
Huge thanks to the incredible team behind this effort.
Proud to have contributed to the DNA do Brasil project and to shed light on Brazil’s rich genetic history.
🔗 Read the paper: science.org/doi/10.1126/...
🧵Thanks for reading! RTs appreciated. #genomics #Brazil #SciComm
Proud to have contributed to the DNA do Brasil project and to shed light on Brazil’s rich genetic history.
🔗 Read the paper: science.org/doi/10.1126/...
🧵Thanks for reading! RTs appreciated. #genomics #Brazil #SciComm
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
science.org
May 16, 2025 at 10:01 AM
Huge thanks to the incredible team behind this effort.
Proud to have contributed to the DNA do Brasil project and to shed light on Brazil’s rich genetic history.
🔗 Read the paper: science.org/doi/10.1126/...
🧵Thanks for reading! RTs appreciated. #genomics #Brazil #SciComm
Proud to have contributed to the DNA do Brasil project and to shed light on Brazil’s rich genetic history.
🔗 Read the paper: science.org/doi/10.1126/...
🧵Thanks for reading! RTs appreciated. #genomics #Brazil #SciComm
Brazil’s complex genetic history matters—for public health, ancestry, and fairness in precision medicine. Including diverse and admixed populations in genomics isn’t just good science—it’s key to understanding and honoring Brazil’s past.
May 16, 2025 at 10:01 AM
Brazil’s complex genetic history matters—for public health, ancestry, and fairness in precision medicine. Including diverse and admixed populations in genomics isn’t just good science—it’s key to understanding and honoring Brazil’s past.
📉 Genomic data reveals the demographic toll of colonization:
Massive effective population size declines
Regional differences in genetic isolation
Long IBD segments in Amazonas (northern Brazilian state) reveal deep founder effects and recent inbreeding
Massive effective population size declines
Regional differences in genetic isolation
Long IBD segments in Amazonas (northern Brazilian state) reveal deep founder effects and recent inbreeding
May 16, 2025 at 10:01 AM
📉 Genomic data reveals the demographic toll of colonization:
Massive effective population size declines
Regional differences in genetic isolation
Long IBD segments in Amazonas (northern Brazilian state) reveal deep founder effects and recent inbreeding
Massive effective population size declines
Regional differences in genetic isolation
Long IBD segments in Amazonas (northern Brazilian state) reveal deep founder effects and recent inbreeding
🧬 We identified ancestry-specific regions under natural selection after admixture:
Genes linked to immune response (MHC/HLA), fertility, metabolism
Selection shaped by regional environments & disease burdens
Especially strong signals from Indigenous ancestry
Genes linked to immune response (MHC/HLA), fertility, metabolism
Selection shaped by regional environments & disease burdens
Especially strong signals from Indigenous ancestry
May 16, 2025 at 10:01 AM
🧬 We identified ancestry-specific regions under natural selection after admixture:
Genes linked to immune response (MHC/HLA), fertility, metabolism
Selection shaped by regional environments & disease burdens
Especially strong signals from Indigenous ancestry
Genes linked to immune response (MHC/HLA), fertility, metabolism
Selection shaped by regional environments & disease burdens
Especially strong signals from Indigenous ancestry
🌍 Brazilian genomes are a mosaic of haplotypes from Indigenous American, African, and European ancestors.
We uncovered fine-scale structure — some individuals were formed by admixture between African populations that likely never met on the continent itself.
We uncovered fine-scale structure — some individuals were formed by admixture between African populations that likely never met on the continent itself.
May 16, 2025 at 10:01 AM
🌍 Brazilian genomes are a mosaic of haplotypes from Indigenous American, African, and European ancestors.
We uncovered fine-scale structure — some individuals were formed by admixture between African populations that likely never met on the continent itself.
We uncovered fine-scale structure — some individuals were formed by admixture between African populations that likely never met on the continent itself.
👩🏽🦱🧔🏻♂️ We reconstructed how admixture shaped Brazilian genomes:
Admixture peaked in the 18th–19th centuries
Initially: sex-biased mating (mostly European men + African/Indigenous women)
Now: ancestry-assortative mating dominates
Admixture peaked in the 18th–19th centuries
Initially: sex-biased mating (mostly European men + African/Indigenous women)
Now: ancestry-assortative mating dominates
May 16, 2025 at 10:01 AM
👩🏽🦱🧔🏻♂️ We reconstructed how admixture shaped Brazilian genomes:
Admixture peaked in the 18th–19th centuries
Initially: sex-biased mating (mostly European men + African/Indigenous women)
Now: ancestry-assortative mating dominates
Admixture peaked in the 18th–19th centuries
Initially: sex-biased mating (mostly European men + African/Indigenous women)
Now: ancestry-assortative mating dominates
💥 Of these new variants, >36,000 are potentially deleterious — affecting immunity, metabolism, and fertility.
Many are rare and ancestry-specific.
We found correlations between ancestry proportions and deleterious variant burden.
Many are rare and ancestry-specific.
We found correlations between ancestry proportions and deleterious variant burden.
May 16, 2025 at 10:01 AM
💥 Of these new variants, >36,000 are potentially deleterious — affecting immunity, metabolism, and fertility.
Many are rare and ancestry-specific.
We found correlations between ancestry proportions and deleterious variant burden.
Many are rare and ancestry-specific.
We found correlations between ancestry proportions and deleterious variant burden.
🧬 We generated 2,723 whole-genome sequences (avg. 35x coverage) from across Brazil's 5 regions: including urban, rural, and riverine populations.
This is one of the largest WGS datasets from Latin America.
And we found 8.7 million variants not seen in public datasets.
This is one of the largest WGS datasets from Latin America.
And we found 8.7 million variants not seen in public datasets.
May 16, 2025 at 10:01 AM
🧬 We generated 2,723 whole-genome sequences (avg. 35x coverage) from across Brazil's 5 regions: including urban, rural, and riverine populations.
This is one of the largest WGS datasets from Latin America.
And we found 8.7 million variants not seen in public datasets.
This is one of the largest WGS datasets from Latin America.
And we found 8.7 million variants not seen in public datasets.
🇧🇷 Brazil is home to the world’s largest recently admixed population — shaped by millions of Europeans, enslaved Africans, and Indigenous peoples.
Yet, its genomic diversity remains underrepresented in global databases.
We set out to change that.
Yet, its genomic diversity remains underrepresented in global databases.
We set out to change that.
May 16, 2025 at 10:01 AM
🇧🇷 Brazil is home to the world’s largest recently admixed population — shaped by millions of Europeans, enslaved Africans, and Indigenous peoples.
Yet, its genomic diversity remains underrepresented in global databases.
We set out to change that.
Yet, its genomic diversity remains underrepresented in global databases.
We set out to change that.