Marcos Castro e Silva, PhD 🇧🇷
@macscastro.bsky.social
Postdoc fellow at @IBE_Barcelona @UPFBarcelona • Interested in how genomics can help us understand human history and evolution • he/him
Pinned
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
science.org
🚨 Our new paper is out in Science!
We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health.
📄 science.org/doi/10.1126/...
🧵👇
We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health.
📄 science.org/doi/10.1126/...
🧵👇
Reposted by Marcos Castro e Silva, PhD 🇧🇷
Excited to share our new preprint🙌
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts https://www.medrxiv.org/content/10.1101/2025.09.01.25334828v1
September 3, 2025 at 8:24 AM
Excited to share our new preprint🙌
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
It's the first human WGS study in Sudan. We uncover one of the strongest selection signals to date, pointing to post-admixture adaptation to malaria in Copts. Huge thanks to all co-authors. @aidaandres.bsky.social @jgarcia-cal.bsky.social @ebosch1972.bsky.social
Reposted by Marcos Castro e Silva, PhD 🇧🇷
Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts https://www.medrxiv.org/content/10.1101/2025.09.01.25334828v1
September 3, 2025 at 12:40 AM
Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts https://www.medrxiv.org/content/10.1101/2025.09.01.25334828v1
Reposted by Marcos Castro e Silva, PhD 🇧🇷
A very special paper where we did something NEW! 🔥combining a large genetic dataset 🧬, a large linguistic dataset 💬, and Bayesian multilevel logistic regressions 📈, counting the effects of areal contact (geographic constrains) 🌎. Genetic admixture explains higher levels of linguistic exchanges...
Our paper is out! We linked genetic and linguistic data to study how contact changes language and found consistent patterns of borrowing across contact situations
@balthasarbickel.bsky.social @chiarabarbieri.bsky.social @nccrlanguage.bsky.social @isle-uzh.bsky.social
doi.org/10.1126/sciadv.adv7521
@balthasarbickel.bsky.social @chiarabarbieri.bsky.social @nccrlanguage.bsky.social @isle-uzh.bsky.social
doi.org/10.1126/sciadv.adv7521
Patterns of genetic admixture reveal similar rates of borrowing across diverse scenarios of language contact
Human population contact leads to consistently similar rates of linguistic borrowing, but effects vary across linguistic features.
www.science.org
August 30, 2025 at 1:56 PM
A very special paper where we did something NEW! 🔥combining a large genetic dataset 🧬, a large linguistic dataset 💬, and Bayesian multilevel logistic regressions 📈, counting the effects of areal contact (geographic constrains) 🌎. Genetic admixture explains higher levels of linguistic exchanges...
Reposted by Marcos Castro e Silva, PhD 🇧🇷
Seeing how every effort has now materialized into lessons and teachings that truly benefit @ibe-barcelona.bsky.social scientists of all generations has been immeasurable. Thank you, @xavimartiperez.bsky.social, for co-leading this project.
📣Today the #IBE_Barcelona Students Committee organizes the #IBEWorkshop, a new initiative aimed at fostering knowledge exchange, skill development, and community building across all levels of the institute.🤩
#UnravellingEvolution
#DiscoveringLife
#ConservingBiodiversity
#UnravellingEvolution
#DiscoveringLife
#ConservingBiodiversity
June 16, 2025 at 9:17 PM
Seeing how every effort has now materialized into lessons and teachings that truly benefit @ibe-barcelona.bsky.social scientists of all generations has been immeasurable. Thank you, @xavimartiperez.bsky.social, for co-leading this project.
Reposted by Marcos Castro e Silva, PhD 🇧🇷
Caçadores humanos podem ter sido os principais algozes das preguiças-gigantes. Análises evolutivas indicam que a disseminação de Homo sapiens pela América coincidiu com picos de extinção bit.ly/43dhPTf
#paleontologia #biodiversidade #evolução #zoologia
#paleontologia #biodiversidade #evolução #zoologia
Caçadores humanos podem ter sido os principais algozes das preguiças-gigantes
Imagine uma paisagem no Pantanal ou no Pampa, com suas amplidões de vegetação rasteira, entrecortada por imensos animais de até 4 toneladas, as preguiças-gigantes. No litoral, seria possível encontrar...
bit.ly
May 22, 2025 at 9:26 PM
Caçadores humanos podem ter sido os principais algozes das preguiças-gigantes. Análises evolutivas indicam que a disseminação de Homo sapiens pela América coincidiu com picos de extinção bit.ly/43dhPTf
#paleontologia #biodiversidade #evolução #zoologia
#paleontologia #biodiversidade #evolução #zoologia
🚨 Our new paper is out in Science!
We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health.
📄 science.org/doi/10.1126/...
🧵👇
We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health.
📄 science.org/doi/10.1126/...
🧵👇
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
science.org
May 16, 2025 at 10:01 AM
🚨 Our new paper is out in Science!
We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health.
📄 science.org/doi/10.1126/...
🧵👇
We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health.
📄 science.org/doi/10.1126/...
🧵👇
Reposted by Marcos Castro e Silva, PhD 🇧🇷
Quase todos os brasileiros são miscigenados, diz estudo
Maior análise de DNA já feita mostra que quase todos os brasileiros são miscigenados
Pesquisa também aponta herança indígena mais substancial do que se imaginava antes
www1.folha.uol.com.br
May 15, 2025 at 6:03 PM
Quase todos os brasileiros são miscigenados, diz estudo
Reposted by Marcos Castro e Silva, PhD 🇧🇷
Very proud of my colleagues and friends for their amazing publication out in Science today!
Nunes et al. "Admixture’s impact on Brazilian population evolution and health" www.science.org/doi/10.1126/...
@hunemeier.bsky.social @macscastro.bsky.social 👏
Nunes et al. "Admixture’s impact on Brazilian population evolution and health" www.science.org/doi/10.1126/...
@hunemeier.bsky.social @macscastro.bsky.social 👏
Admixture’s impact on Brazilian population evolution and health
Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who...
www.science.org
May 15, 2025 at 6:04 PM
Very proud of my colleagues and friends for their amazing publication out in Science today!
Nunes et al. "Admixture’s impact on Brazilian population evolution and health" www.science.org/doi/10.1126/...
@hunemeier.bsky.social @macscastro.bsky.social 👏
Nunes et al. "Admixture’s impact on Brazilian population evolution and health" www.science.org/doi/10.1126/...
@hunemeier.bsky.social @macscastro.bsky.social 👏