Luis Guerra
@luisguerra.bsky.social
Lecturer/Assistant Professor in Pharmacology.
Interest: Neurobiology, the evolution of the nervous system, GPCR deorphanisation, non-bilaterians.
Interest: Neurobiology, the evolution of the nervous system, GPCR deorphanisation, non-bilaterians.
is an ancient eukaryotic complex. in humans it sets neuronal resting excitability; in fungi it mediates stress-evoked Ca²⁺ entry. Its widespread distribution in eukaryotes shows this complex originated early in eukaryotes, and was later co-opted to regulate neuronal resting excitability in animals.
September 16, 2025 at 1:27 PM
is an ancient eukaryotic complex. in humans it sets neuronal resting excitability; in fungi it mediates stress-evoked Ca²⁺ entry. Its widespread distribution in eukaryotes shows this complex originated early in eukaryotes, and was later co-opted to regulate neuronal resting excitability in animals.
Evolutionarily speaking, the most interesting part for me, is the demonstration that polyamine block in glutamate receptors is an ancestral regulatory mechanism that predates bilaterians, showing that key aspects of synaptic physiology arose early in animal evolution (prebilaterian).
September 16, 2025 at 1:17 PM
Evolutionarily speaking, the most interesting part for me, is the demonstration that polyamine block in glutamate receptors is an ancestral regulatory mechanism that predates bilaterians, showing that key aspects of synaptic physiology arose early in animal evolution (prebilaterian).
I would say is really good. The only part I did not like is that they have a "personality test" thing that is very dubious and pseudo-scientific. Otherwise I think is good!. The place is beautiful and the food is good. I would say that I mostly recommend it :)
May 14, 2025 at 5:26 PM
I would say is really good. The only part I did not like is that they have a "personality test" thing that is very dubious and pseudo-scientific. Otherwise I think is good!. The place is beautiful and the food is good. I would say that I mostly recommend it :)
Ya habia leido este paper I me parecio fantastico. Me da mucho gusto que tambien seas mexicano, excelente trabajo!
May 1, 2025 at 5:20 PM
Ya habia leido este paper I me parecio fantastico. Me da mucho gusto que tambien seas mexicano, excelente trabajo!
He was my postdoc supervisor :D. Hehehe I obtained funding for this project in 2022 that allowed me to start my own laboratory :). Thanks for sharing
April 29, 2025 at 10:25 PM
He was my postdoc supervisor :D. Hehehe I obtained funding for this project in 2022 that allowed me to start my own laboratory :). Thanks for sharing
🧪Then, we identified that the receptors that are activated by monoamines in placozoans are homologous to bilaterian receptors! #Science
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Functional and phylogenetic analysis of placozoan GPCRs reveal the prebilaterian origin of monoaminergic signalling
Monoamines are biologically active compounds crucial for neurotransmission and various physiological processes. They include neurotransmitters like serotonin, dopamine, and melatonin, which regulate m...
www.biorxiv.org
April 29, 2025 at 2:12 PM
🧪Then, we identified that the receptors that are activated by monoamines in placozoans are homologous to bilaterian receptors! #Science
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
We also identified receptors that mediate these effects in placozoans. By using large-scale deorphanisation, we found that these monoamines are the most active for certain placozoan receptors. Phylogenies demonstrate that these receptors are orthologs of bilaterian melatonin receptors!!
April 28, 2025 at 5:09 PM
We also identified receptors that mediate these effects in placozoans. By using large-scale deorphanisation, we found that these monoamines are the most active for certain placozoan receptors. Phylogenies demonstrate that these receptors are orthologs of bilaterian melatonin receptors!!
Can you add me please? scholar.google.com/citations?us...
scholar.google.com
April 28, 2025 at 8:54 AM
Can you add me please? scholar.google.com/citations?us...
Hi @erynmcfarlane.bsky.social I am an evolutionary biologist working in the evolution of the nervous system, can you add me to the list?
Here is my google scholar and ORCID
orcid.org/0000-0002-25...
scholar.google.com/citations?us...
Here is my google scholar and ORCID
orcid.org/0000-0002-25...
scholar.google.com/citations?us...
ORCID
orcid.org
April 25, 2025 at 8:33 PM
Hi @erynmcfarlane.bsky.social I am an evolutionary biologist working in the evolution of the nervous system, can you add me to the list?
Here is my google scholar and ORCID
orcid.org/0000-0002-25...
scholar.google.com/citations?us...
Here is my google scholar and ORCID
orcid.org/0000-0002-25...
scholar.google.com/citations?us...
Then, we demonstrate that these receptors are homologous to bilaterian receptors, particularly human melatonin receptors. Demonstrating that the monoamine system is more ancestral than originally thought. We resolved this problem thanks to the use of pharmacology #Melatonin #GPCRs #Pharmacology
April 24, 2025 at 9:52 AM
Then, we demonstrate that these receptors are homologous to bilaterian receptors, particularly human melatonin receptors. Demonstrating that the monoamine system is more ancestral than originally thought. We resolved this problem thanks to the use of pharmacology #Melatonin #GPCRs #Pharmacology
Can I be added please?
November 30, 2024 at 7:20 AM
Can I be added please?