...opportunities always popping up across the College and wider Institute. Definitely get in touch with our HoD Prof Joan Geoghegan if you are interested

I should also say, from a personal perspective, being in the Department of MIM is lovely - I have great colleagues and I find it to be a very positive environment. We have great grant writing support from each other and from the grant submission team. There are also loads of exciting...

We screened several uncharacterised putative PNGases and discovered PNGaseL has very broad activity against N-glycans from mammalian, insect and plant-derived proteins. This enzyme has fantastic practical applications and is on sale at our industrial partner Ludger www.ludger.com/product-cata...

Thanks Alex! we will consider your comments

Hi Chris, for B.bifidum I can't see any putative high-mannose breakdown CAZymes, but other species do have these. There has been a characterisation in B. longum.
www.nature.com/articles/s41...

We also generated a model for host glycan breakdown for Bifidobacterium bifidum based on this and previously published works.

The structure reveals a C-shaped pocket that likely accommodates peptides and modelling of peptides into this pocket supports this hypothesis.

Biochemical characterisation revealed that this enzyme has a preference for N-glycans attached to peptides rather than denatured or native proteins, which suggests that microbes with these enzymes target these types of glycoproteins for use as a nutrient source.

Here we describe the first structure of a PNGaseA superfamily member. This structure has the canonical PNGase two β-sandwich catalytic module (pink/gold), but also a large unique β-sheet cradle (silver).

If you would like to buy some from Ludger:
www.ludger.com/product-cata...

Thanks very much Jose! I can't take credit for the title, it was an idea of one of the other amazing supervisors 😆