Excited for the amazing line up at the Society for Glycobiology annual meeting 2025 #glycotime

We also generated a model for host glycan breakdown for Bifidobacterium bifidum based on this and previously published works.

The structure reveals a C-shaped pocket that likely accommodates peptides and modelling of peptides into this pocket supports this hypothesis.

Biochemical characterisation revealed that this enzyme has a preference for N-glycans attached to peptides rather than denatured or native proteins, which suggests that microbes with these enzymes target these types of glycoproteins for use as a nutrient source.

Here we describe the first structure of a PNGaseA superfamily member. This structure has the canonical PNGase two β-sandwich catalytic module (pink/gold), but also a large unique β-sheet cradle (silver).

New paper from Andy Lovering's group defining pentameric porin-like superstructures in Gram-negative bacteria 🦠@unibirmingham.bsky.social @imibirmingham.bsky.social

Leah Burgess has joined the group this week #glycobiology 🍬
@leahburgess.bsky.social Leah will be exploring Clostridium perfringens CAZyme activity against host glycans also supervised by @halllab.bsky.social

Science holiday #glycotime 🍭❄️

Cassie Bakshani giving a fantastic talk on her work on Akkermansia enzymes breaking down host glycans #cbm15 #glycotime