eric lai
@lucksmith.bsky.social
study small RNAs/APA/splicing/m6A/Notch. neural development+behavior; genomic conflict+evolution.
http://www.mskcc.org/lai
also, indie rock and glassblowing.
http://www.mskcc.org/lai
also, indie rock and glassblowing.
one more satisfying thing on the biochemical mechanisms of aberrant miRNA biogenesis in Dicer cancer hotspot settings. our friends in Shuo Gu's lab (NIH) got same results by testing a different Dicer mutation, and different species (mouse). so it must be true!! 4/4
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch - Nature Structural & Molecular Biology
Malagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger micro...
www.nature.com
November 10, 2025 at 4:43 PM
one more satisfying thing on the biochemical mechanisms of aberrant miRNA biogenesis in Dicer cancer hotspot settings. our friends in Shuo Gu's lab (NIH) got same results by testing a different Dicer mutation, and different species (mouse). so it must be true!! 4/4
www.nature.com/articles/s41...
www.nature.com/articles/s41...
upregulation of miRNA-3p passengers is the broadest "strand switching" effect we know of. more importantly, Dicer cancer hotspots induce loss and gain of miRNA function: important for thinking targeted therapy. congrats david jee and seungjae lee for uncovering this biochemical+genomic mystery! 3/4
a man wearing glasses and a black turtleneck is holding a pair of headphones .
ALT: a man wearing glasses and a black turtleneck is holding a pair of headphones .
media.tenor.com
November 10, 2025 at 4:43 PM
upregulation of miRNA-3p passengers is the broadest "strand switching" effect we know of. more importantly, Dicer cancer hotspots induce loss and gain of miRNA function: important for thinking targeted therapy. congrats david jee and seungjae lee for uncovering this biochemical+genomic mystery! 3/4
Dicer cancer hotspots impair RNaseIIIb, but not RNaseIIIa activity, and was known to prevent miRNA-5p biogenesis. surprisingly, we find a selective defect in miRNA-3p levels: they directionally go UP, but only if they are normally passenger strands. we show these are functional for silencing! 2/4
November 10, 2025 at 4:43 PM
Dicer cancer hotspots impair RNaseIIIb, but not RNaseIIIa activity, and was known to prevent miRNA-5p biogenesis. surprisingly, we find a selective defect in miRNA-3p levels: they directionally go UP, but only if they are normally passenger strands. we show these are functional for silencing! 2/4
did you used to live here? funny thing, we had been in sunshine laundromat earlier in the day (see other post), you'd think every place in brooklyn had a secret speakeasy hidden in back!
November 10, 2025 at 2:09 AM
did you used to live here? funny thing, we had been in sunshine laundromat earlier in the day (see other post), you'd think every place in brooklyn had a secret speakeasy hidden in back!
douglas adams gave a talk when i was in college (1992?) and of course i was there! looking for my picture with him, it's in a box somewhere...
November 9, 2025 at 2:05 PM
douglas adams gave a talk when i was in college (1992?) and of course i was there! looking for my picture with him, it's in a box somewhere...
NYAS site maintains this webpage of the panel with Utley, noting "What follows is an abridged transcript of their conversation." they removed all of Watson's atrocious and misogynistic lines...
anyways, the rifkind's movie is great and very real, try to find it! 2/2
www.nyas.org/ideas-insigh...
anyways, the rifkind's movie is great and very real, try to find it! 2/2
www.nyas.org/ideas-insigh...
How Science Can Keep America Globally Competitive
Learn what it will take to keep the US science talent pipeline pumping out quality, competitive professionals.
www.nyas.org
November 8, 2025 at 3:53 AM
NYAS site maintains this webpage of the panel with Utley, noting "What follows is an abridged transcript of their conversation." they removed all of Watson's atrocious and misogynistic lines...
anyways, the rifkind's movie is great and very real, try to find it! 2/2
www.nyas.org/ideas-insigh...
anyways, the rifkind's movie is great and very real, try to find it! 2/2
www.nyas.org/ideas-insigh...
the BBC radio drama version was the best! btw i was just reminiscing to someone that i got to meet douglas adams when i was in college.
November 6, 2025 at 3:45 AM
the BBC radio drama version was the best! btw i was just reminiscing to someone that i got to meet douglas adams when i was in college.
Reposted by eric lai
[P] Found a higher-quality photo; IT *IS* TAPED UP SHEETS OF PAPER!
November 5, 2025 at 7:22 PM
[P] Found a higher-quality photo; IT *IS* TAPED UP SHEETS OF PAPER!
jan, bryan was at msk today?! i could have dropped by...
November 6, 2025 at 1:42 AM
jan, bryan was at msk today?! i could have dropped by...