3/4 As learning progressed, the mice learned to coordinate the prosthesis movements across dimensions, and they managed to consolidate a dominant prosthesis trajectory that led to rewards.

2/4 Our prosthesis can perform movements in a 3D space next to the body of the mice, that control it via a chronic invasive brain-machine interface. We show that the mice can drive it in a 2D subspace, while some mice managed to control it also in a 3D space.

1/4 Today we introduce the first upper limb prosthesis for the mouse model, controlled by a brain-machine interface! We show that mice can control this prosthesis via a brain-machine interface to solve a rewarded task.

5/6 During cortical wave generation, the response to the movement was reshaped, and lost its relation to limb amplitude, likely being processed to match the task instead.

4/6 Importantly, limb movements were likely required to trigger rewardable waves, but were only successful when the cortex was in the specific, suppressed state.

3/6 We have now gone much further, and show that learning this task triggers a reshaping of the cortical dynamics, including a strong suppression of activity before rewardable wave.

2/6 One year ago, we showed that mice can learn to guide mesoscale cortical of the somatosensory cortex from a start to a target area to obtain rewards.

1/6 We have a new/updated preprint out, led by Anton Dogadov, demonstrating operant conditioning of large cortical waves over mouse S1 thanks to a mesoscale GCamp6 brain-machine interface!
www.biorxiv.org/content/10.1...

4/ During this behavior we tracked pupillary movements, and we found that the mice moved their eye towards the threat in a stronger and more prolonged manner following the embodiment step than in several control conditions that match the canonical controls used in human experiment!

3/ So far, there has been few works on embodiment in the mouse model. Here we reproduce key elements of the rubber hand illusion paradigm in the mouse model, including the use of brushes to induce visuotactile -triggered embodiment, followed by the presentation of a threat to the artificial limb.

▶️Braincoder, the BMI feedback conference, features outstanding speakers include Edouardo Fernandez (V1 microstimulation), Guillaume Charvet (Clinatec), Mickael Tanter (fUS), and more international speakers!

▶️We are awaiting your registration! braincoder.sciencesconf.org

🌊 Post-doctoral researcher Anton Dogadov @ToxaDog will demonstrate operant conditioning of cortical waves in his talk at @SfNtweets in Washington.

📆 Join him on the 15th of November (session NANO88.11)

🧑🏻‍🏫 Check out his associated electronic poster here: cattendee.abstractsonline.com/meeting/10892

Back from beautiful Tübingen, from an amazing visit to Cornelius Schwarz laboratory. Thank you for the hospitality and the great science!