Luc Estebanez
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lucestebanez.bsky.social
Luc Estebanez
@lucestebanez.bsky.social
Brain-machine interfaces, Neuroprostheses.
CNRS, Paris-Saclay Institute of Neuroscience @NeuroPSI.bsky.social
https://neuropsi.cnrs.fr/annuaire/luc-estebanez/

Member of team @TouchMoveLab.bsky.social
C'est visiblement mal étudié encore, mais ça semble équivalent au tabac ou pire. Respirer des produits de combustion n'est jamais bon... Voici un exemple de méta-analyse en français:
doi.org/10.1016/j.rmra.2024.11.128
November 5, 2025 at 10:14 AM
4/4
➡️ Read our manuscript on the link below 🔽🔽🔽
➡️ Many thanks to our collaborators at L2S @centralesupelec.bsky.social , and to all members of the @touchmovelab.bsky.social‬ for their key input to this project.
➡️ Funding from Fondation 3DS and @agencerecherche.bsky.social
Cortical control of a forelimb prosthesis in mice
Robotic upper-limb prostheses aim to restore the autonomy of paralyzed patients and amputees. So far, advances in this field have relied on monkey pre-clinical and human clinical research. Here, we re...
www.biorxiv.org
September 4, 2025 at 9:29 AM
3/4 As learning progressed, the mice learned to coordinate the prosthesis movements across dimensions, and they managed to consolidate a dominant prosthesis trajectory that led to rewards.
September 4, 2025 at 9:29 AM
2/4 Our prosthesis can perform movements in a 3D space next to the body of the mice, that control it via a chronic invasive brain-machine interface. We show that the mice can drive it in a 2D subspace, while some mice managed to control it also in a 3D space.
September 4, 2025 at 9:29 AM
6/6 This is all thanks to the incredibly talented and passionate Anton Dogadov, who carried this whole study!

Thanks for feedback on our first version of the paper from @gbouvier.bsky.social vier.bsky.social‬ at @neuropsi.bsky.social, Jean-François Léger @ibensens.bsky.social and many others!
August 1, 2025 at 6:25 AM
5/6 During cortical wave generation, the response to the movement was reshaped, and lost its relation to limb amplitude, likely being processed to match the task instead.
August 1, 2025 at 6:25 AM
4/6 Importantly, limb movements were likely required to trigger rewardable waves, but were only successful when the cortex was in the specific, suppressed state.
August 1, 2025 at 6:25 AM
3/6 We have now gone much further, and show that learning this task triggers a reshaping of the cortical dynamics, including a strong suppression of activity before rewardable wave.
August 1, 2025 at 6:25 AM
2/6 One year ago, we showed that mice can learn to guide mesoscale cortical of the somatosensory cortex from a start to a target area to obtain rewards.
August 1, 2025 at 6:25 AM