Lucas Barea-Moya
@lucasbarea.bsky.social
neurologist and researcher | Immunotherapy and Biomodels of Autoimmunity | brain organoids | multiple sclerosis | CAR T
Reposted by Lucas Barea-Moya
4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions
Inferring cellular and molecular dynamics of multiple sclerosis (MS) lesions from postmortem tissue collected decades after onset is challenging. Using magnetic resonance image (MRI)–guided spatiotemp...
www.science.org
February 27, 2025 at 8:30 PM
4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Lucas Barea-Moya
AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD
actaneurocomms.biomedcentral.com/articles/10....
actaneurocomms.biomedcentral.com/articles/10....
AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD - Acta Neuropathologica Communications
Neuromyelitis optica spectrum disorder (NMOSD) is a paradigmatic autoimmune disease of the central nervous system (CNS), in which the water channel protein Aquaporin-4 (AQP4) is targeted by a self-rea...
actaneurocomms.biomedcentral.com
February 14, 2025 at 4:08 PM
AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD
actaneurocomms.biomedcentral.com/articles/10....
actaneurocomms.biomedcentral.com/articles/10....
Reposted by Lucas Barea-Moya
1/2 Super excited to see this finally out @naturecomms.bsky.social ! We developed an off-the-shelf T cell receptor T cell therapy for patients with glioblastoma from a peptide vaccinated patient. Looking very much forward to its translation within DKTK supported by HI-TRON!
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications
Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...
www.nature.com
February 2, 2025 at 9:08 PM
1/2 Super excited to see this finally out @naturecomms.bsky.social ! We developed an off-the-shelf T cell receptor T cell therapy for patients with glioblastoma from a peptide vaccinated patient. Looking very much forward to its translation within DKTK supported by HI-TRON!
Reposted by Lucas Barea-Moya
Reposted by Lucas Barea-Moya
Novel Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Novel Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies
This case series evaluates patients in China who presented with an unknown meningoencephalomyelitis syndrome associated with an astrocytic autoantibody.
jamanetwork.com
January 21, 2025 at 8:34 PM
Novel Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment.
Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment.
With the goal to overcome the limited treatment options and poor prognosis of glioblastoma (GBM), we have developed a PD-L1-targeting CAR T cell therapy, MC9999. In vitro experiments with MC9999 CAR T...
www.biorxiv.org
November 25, 2024 at 6:44 PM
Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment.
Reposted by Lucas Barea-Moya
November 18, 2024 at 12:41 AM
Let's see what's going on here... I am interested in immunotherapies and the study of neurological diseases through stem cell models, including brain organoids. Curious about science and passionate about literature and culture in general.
November 17, 2024 at 7:02 AM
Let's see what's going on here... I am interested in immunotherapies and the study of neurological diseases through stem cell models, including brain organoids. Curious about science and passionate about literature and culture in general.