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Interesting 🤔

Are you able to share this? I can't access it via any of my usual options.

I agree, better dosing, better kinetics, but it's one of those odd things that my institution has been against switching to. I might need to revisit and see if I can make it happen..

Will read these today. Thank you both for sharing.

Will be great to see!

Agreed. Several are pushing it as blanket statement QID for specific indications and TID never. But I suppose that leans on the safer side, if the patient takes it.

I receive a lot of pushback on TID dosing from the ID community here (Mostly other institutions). Several of the docs and pharmacists really push for 1g QID even for things like pyelo, uncomplicated GNB (who had IV lead-in) , cellulitis.

In this specific case, we do an enterococcus, but I think strep is what we are really dealing with

@bradspellberg.bsky.social The osteo wikiguidelikes trials look like the all did BID with this dosing but TID seems logical and I believe there are someone studies looking at higher bone penetration. Thoughts?

With my small N, yes. Assuming compliance

Vanco/PipTazo/Clinda or Linezolid/PipTazo. Would love to make the switch to Linezolid + Ceftriaxone but a hard sell here.