Leigh-Ana Rossitto
@lrossitto.bsky.social
just one brain studying other brains | UCSD BMS phd candidate studying brain metabolism, nutrient signaling, and neurodegen | @mitbrainandcog alum | 👩🏻🔬🌈 #FirstGen
Reposted by Leigh-Ana Rossitto
I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology
Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...
www.nature.com
March 26, 2025 at 2:02 PM
I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
excited to see this out! congrats to your team!
Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Madhavan et al. identify and characterize the selective regulation of protein solubility
by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure
rescues cell-based and C. ele...
www.cell.com
December 3, 2024 at 7:14 PM
excited to see this out! congrats to your team!